A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial Chemoembolization
Abstract Transarterial chemoembolization (TACE) utilizing a water‐in‐oil lipiodol emulsion is a preferable therapeutic strategy for advanced liver cancer in clinical practice. However, the low stability of the lipiodol emulsion and poor efficacy of chemotherapeutic drug seriously undermine the effic...
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2025-02-01
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Online Access: | https://doi.org/10.1002/advs.202410873 |
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author | Xiancheng Xia Yang Li Rongkang Huang Yuanbin Wang Wenxuan Xiong Hui Zhou Min Li Xidong Lin Youchen Tang Bo Zhang |
author_facet | Xiancheng Xia Yang Li Rongkang Huang Yuanbin Wang Wenxuan Xiong Hui Zhou Min Li Xidong Lin Youchen Tang Bo Zhang |
author_sort | Xiancheng Xia |
collection | DOAJ |
description | Abstract Transarterial chemoembolization (TACE) utilizing a water‐in‐oil lipiodol emulsion is a preferable therapeutic strategy for advanced liver cancer in clinical practice. However, the low stability of the lipiodol emulsion and poor efficacy of chemotherapeutic drug seriously undermine the efficiency of TACE. Herein, a novel lobaplatin‐loaded lipiodol emulsion (denoted as ICN‐LPE) is developed by constructing a lipiodol Pickering emulsion (LPE) stabilized with iron‐doped carbon nanozymes (ICN) to mitigate the issue of lipiodol‐water separation. This novel emulsion not only solves the instability of conventional lipiodol emulsions, but also facilitates the sustained release of lobaplatin. More importantly, upon entry into tumor cells, ICN catalyze the generation of reactive oxygen species via the Fenton‐like reaction while simultaneously consuming intracellular glutathione, thereby inducing tumor cell death via chemodynamic therapy. By integrating chemotherapy and chemodynamic therapy, ICN‐LPE demonstrates a synergistic antitumor effect and effectively inhibits tumor growth in a rabbit liver tumor model. Therefore, our ICN‐LPE shows an appealing clinical application prospect for TACE. |
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institution | Kabale University |
issn | 2198-3844 |
language | English |
publishDate | 2025-02-01 |
publisher | Wiley |
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series | Advanced Science |
spelling | doaj-art-7f2bf5c119874e67b39b82acad67b63b2025-02-04T13:14:54ZengWileyAdvanced Science2198-38442025-02-01125n/an/a10.1002/advs.202410873A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial ChemoembolizationXiancheng Xia0Yang Li1Rongkang Huang2Yuanbin Wang3Wenxuan Xiong4Hui Zhou5Min Li6Xidong Lin7Youchen Tang8Bo Zhang9Department of Interventional Center Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat‐Sen University Guangzhou 510655 P. R. ChinaThe Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen 518033 P. R. ChinaDepartment of General Surgery (Colorectal Surgery) Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat‐Sen University Guangzhou 510655 P. R. ChinaDepartment of General Surgery (Colorectal Surgery) Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat‐Sen University Guangzhou 510655 P. R. ChinaDepartment of General Surgery (Colorectal Surgery) Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat‐Sen University Guangzhou 510655 P. R. ChinaPCFM Lab School of Chemistry Sun Yat‐sen University Guangzhou 510006 P. R. ChinaDepartment of Gastrointestinal Surgery The Affiliated Dongguan Songshan Lake Central Hospital Guangdong Medical University Dongguan 523326 P. R. ChinaFuture Technology School Shenzhen Technology University Shenzhen 518118 P. R. ChinaThe Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen 518033 P. R. ChinaDepartment of Interventional Center Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat‐Sen University Guangzhou 510655 P. R. ChinaAbstract Transarterial chemoembolization (TACE) utilizing a water‐in‐oil lipiodol emulsion is a preferable therapeutic strategy for advanced liver cancer in clinical practice. However, the low stability of the lipiodol emulsion and poor efficacy of chemotherapeutic drug seriously undermine the efficiency of TACE. Herein, a novel lobaplatin‐loaded lipiodol emulsion (denoted as ICN‐LPE) is developed by constructing a lipiodol Pickering emulsion (LPE) stabilized with iron‐doped carbon nanozymes (ICN) to mitigate the issue of lipiodol‐water separation. This novel emulsion not only solves the instability of conventional lipiodol emulsions, but also facilitates the sustained release of lobaplatin. More importantly, upon entry into tumor cells, ICN catalyze the generation of reactive oxygen species via the Fenton‐like reaction while simultaneously consuming intracellular glutathione, thereby inducing tumor cell death via chemodynamic therapy. By integrating chemotherapy and chemodynamic therapy, ICN‐LPE demonstrates a synergistic antitumor effect and effectively inhibits tumor growth in a rabbit liver tumor model. Therefore, our ICN‐LPE shows an appealing clinical application prospect for TACE.https://doi.org/10.1002/advs.202410873chemodynamic therapychemoembolizationliver cancerPickering emulsion |
spellingShingle | Xiancheng Xia Yang Li Rongkang Huang Yuanbin Wang Wenxuan Xiong Hui Zhou Min Li Xidong Lin Youchen Tang Bo Zhang A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial Chemoembolization Advanced Science chemodynamic therapy chemoembolization liver cancer Pickering emulsion |
title | A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial Chemoembolization |
title_full | A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial Chemoembolization |
title_fullStr | A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial Chemoembolization |
title_full_unstemmed | A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial Chemoembolization |
title_short | A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial Chemoembolization |
title_sort | lipiodol pickering emulsion stabilized by iron doped carbon nanozymes for liver transarterial chemoembolization |
topic | chemodynamic therapy chemoembolization liver cancer Pickering emulsion |
url | https://doi.org/10.1002/advs.202410873 |
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