A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial Chemoembolization

Abstract Transarterial chemoembolization (TACE) utilizing a water‐in‐oil lipiodol emulsion is a preferable therapeutic strategy for advanced liver cancer in clinical practice. However, the low stability of the lipiodol emulsion and poor efficacy of chemotherapeutic drug seriously undermine the effic...

Full description

Saved in:
Bibliographic Details
Main Authors: Xiancheng Xia, Yang Li, Rongkang Huang, Yuanbin Wang, Wenxuan Xiong, Hui Zhou, Min Li, Xidong Lin, Youchen Tang, Bo Zhang
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
Online Access:https://doi.org/10.1002/advs.202410873
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832540902807044096
author Xiancheng Xia
Yang Li
Rongkang Huang
Yuanbin Wang
Wenxuan Xiong
Hui Zhou
Min Li
Xidong Lin
Youchen Tang
Bo Zhang
author_facet Xiancheng Xia
Yang Li
Rongkang Huang
Yuanbin Wang
Wenxuan Xiong
Hui Zhou
Min Li
Xidong Lin
Youchen Tang
Bo Zhang
author_sort Xiancheng Xia
collection DOAJ
description Abstract Transarterial chemoembolization (TACE) utilizing a water‐in‐oil lipiodol emulsion is a preferable therapeutic strategy for advanced liver cancer in clinical practice. However, the low stability of the lipiodol emulsion and poor efficacy of chemotherapeutic drug seriously undermine the efficiency of TACE. Herein, a novel lobaplatin‐loaded lipiodol emulsion (denoted as ICN‐LPE) is developed by constructing a lipiodol Pickering emulsion (LPE) stabilized with iron‐doped carbon nanozymes (ICN) to mitigate the issue of lipiodol‐water separation. This novel emulsion not only solves the instability of conventional lipiodol emulsions, but also facilitates the sustained release of lobaplatin. More importantly, upon entry into tumor cells, ICN catalyze the generation of reactive oxygen species via the Fenton‐like reaction while simultaneously consuming intracellular glutathione, thereby inducing tumor cell death via chemodynamic therapy. By integrating chemotherapy and chemodynamic therapy, ICN‐LPE demonstrates a synergistic antitumor effect and effectively inhibits tumor growth in a rabbit liver tumor model. Therefore, our ICN‐LPE shows an appealing clinical application prospect for TACE.
format Article
id doaj-art-7f2bf5c119874e67b39b82acad67b63b
institution Kabale University
issn 2198-3844
language English
publishDate 2025-02-01
publisher Wiley
record_format Article
series Advanced Science
spelling doaj-art-7f2bf5c119874e67b39b82acad67b63b2025-02-04T13:14:54ZengWileyAdvanced Science2198-38442025-02-01125n/an/a10.1002/advs.202410873A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial ChemoembolizationXiancheng Xia0Yang Li1Rongkang Huang2Yuanbin Wang3Wenxuan Xiong4Hui Zhou5Min Li6Xidong Lin7Youchen Tang8Bo Zhang9Department of Interventional Center Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat‐Sen University Guangzhou 510655 P. R. ChinaThe Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen 518033 P. R. ChinaDepartment of General Surgery (Colorectal Surgery) Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat‐Sen University Guangzhou 510655 P. R. ChinaDepartment of General Surgery (Colorectal Surgery) Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat‐Sen University Guangzhou 510655 P. R. ChinaDepartment of General Surgery (Colorectal Surgery) Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat‐Sen University Guangzhou 510655 P. R. ChinaPCFM Lab School of Chemistry Sun Yat‐sen University Guangzhou 510006 P. R. ChinaDepartment of Gastrointestinal Surgery The Affiliated Dongguan Songshan Lake Central Hospital Guangdong Medical University Dongguan 523326 P. R. ChinaFuture Technology School Shenzhen Technology University Shenzhen 518118 P. R. ChinaThe Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen 518033 P. R. ChinaDepartment of Interventional Center Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat‐Sen University Guangzhou 510655 P. R. ChinaAbstract Transarterial chemoembolization (TACE) utilizing a water‐in‐oil lipiodol emulsion is a preferable therapeutic strategy for advanced liver cancer in clinical practice. However, the low stability of the lipiodol emulsion and poor efficacy of chemotherapeutic drug seriously undermine the efficiency of TACE. Herein, a novel lobaplatin‐loaded lipiodol emulsion (denoted as ICN‐LPE) is developed by constructing a lipiodol Pickering emulsion (LPE) stabilized with iron‐doped carbon nanozymes (ICN) to mitigate the issue of lipiodol‐water separation. This novel emulsion not only solves the instability of conventional lipiodol emulsions, but also facilitates the sustained release of lobaplatin. More importantly, upon entry into tumor cells, ICN catalyze the generation of reactive oxygen species via the Fenton‐like reaction while simultaneously consuming intracellular glutathione, thereby inducing tumor cell death via chemodynamic therapy. By integrating chemotherapy and chemodynamic therapy, ICN‐LPE demonstrates a synergistic antitumor effect and effectively inhibits tumor growth in a rabbit liver tumor model. Therefore, our ICN‐LPE shows an appealing clinical application prospect for TACE.https://doi.org/10.1002/advs.202410873chemodynamic therapychemoembolizationliver cancerPickering emulsion
spellingShingle Xiancheng Xia
Yang Li
Rongkang Huang
Yuanbin Wang
Wenxuan Xiong
Hui Zhou
Min Li
Xidong Lin
Youchen Tang
Bo Zhang
A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial Chemoembolization
Advanced Science
chemodynamic therapy
chemoembolization
liver cancer
Pickering emulsion
title A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial Chemoembolization
title_full A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial Chemoembolization
title_fullStr A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial Chemoembolization
title_full_unstemmed A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial Chemoembolization
title_short A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial Chemoembolization
title_sort lipiodol pickering emulsion stabilized by iron doped carbon nanozymes for liver transarterial chemoembolization
topic chemodynamic therapy
chemoembolization
liver cancer
Pickering emulsion
url https://doi.org/10.1002/advs.202410873
work_keys_str_mv AT xianchengxia alipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT yangli alipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT rongkanghuang alipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT yuanbinwang alipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT wenxuanxiong alipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT huizhou alipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT minli alipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT xidonglin alipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT youchentang alipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT bozhang alipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT xianchengxia lipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT yangli lipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT rongkanghuang lipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT yuanbinwang lipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT wenxuanxiong lipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT huizhou lipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT minli lipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT xidonglin lipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT youchentang lipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization
AT bozhang lipiodolpickeringemulsionstabilizedbyirondopedcarbonnanozymesforlivertransarterialchemoembolization