Multifunctional natural chlorogenic acid based nanocarrier for Alzheimer's disease treatment
Alzheimer's disease (AD) presents significant challenges due to its intricate pathogenic mechanisms and the limited efficacy of single-target therapies. In this study, we investigated the potential of chlorogenic acid (CHA), a multifunctional natural active compound, in AD therapy by developing...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425004016 |
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| author | Chenchen Wang Xiaolei Song Xiaowan Zhang Peng Li Wei Wei Shihao Sun Yong Chen |
| author_facet | Chenchen Wang Xiaolei Song Xiaowan Zhang Peng Li Wei Wei Shihao Sun Yong Chen |
| author_sort | Chenchen Wang |
| collection | DOAJ |
| description | Alzheimer's disease (AD) presents significant challenges due to its intricate pathogenic mechanisms and the limited efficacy of single-target therapies. In this study, we investigated the potential of chlorogenic acid (CHA), a multifunctional natural active compound, in AD therapy by developing a trifunctional nanocarrier (MC-H/R/si). CHA was effectively conjugated with iron-based metal-organic frameworks (MIL/Fe-100) through chelation interaction. The resulting nanocomplex (MC) not only enhances the bioavailability of CHA but also facilitates a synergistic antioxidant effect between CHA and MIL/Fe-100. Importantly, CHA can chelate Zn2+ from β-amyloid/Zn2+ (Aβ/Zn2+) polymers, inhibiting Aβ aggregation. Furthermore, small interfering RNA targeting BACE1 was covalently linked to MC to downregulate BACE1 expression. Both in vitro and in vivo experiments revealed that MC-H/R/si effectively scavenges ROS, reduces inflammation and Aβ plaque, and improves the learning and cognitive abilities of APP/PS1 mice. These findings confirm that the trifunctional nanocarrier MC-H/R/si has great potential for AD treatment. |
| format | Article |
| id | doaj-art-7f2797803272494bb3ab16ef4b16d0ca |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-7f2797803272494bb3ab16ef4b16d0ca2025-08-20T02:28:37ZengElsevierMaterials Today Bio2590-00642025-06-013210184110.1016/j.mtbio.2025.101841Multifunctional natural chlorogenic acid based nanocarrier for Alzheimer's disease treatmentChenchen Wang0Xiaolei Song1Xiaowan Zhang2Peng Li3Wei Wei4Shihao Sun5Yong Chen6Beijing Life Science Academy, Yingcai South 1st Street, Changping District, Beijing, 102200, PR China; Jiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, PR ChinaJiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, PR ChinaJiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, PR ChinaBeijing Life Science Academy, Yingcai South 1st Street, Changping District, Beijing, 102200, PR ChinaJiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, PR China; Corresponding author. Southeast University, Nanjing, 210001, PR China.Beijing Life Science Academy, Yingcai South 1st Street, Changping District, Beijing, 102200, PR China; Corresponding author. Beijing Life Science Academy, Beijing, 102200, PR China.Beijing Life Science Academy, Yingcai South 1st Street, Changping District, Beijing, 102200, PR ChinaAlzheimer's disease (AD) presents significant challenges due to its intricate pathogenic mechanisms and the limited efficacy of single-target therapies. In this study, we investigated the potential of chlorogenic acid (CHA), a multifunctional natural active compound, in AD therapy by developing a trifunctional nanocarrier (MC-H/R/si). CHA was effectively conjugated with iron-based metal-organic frameworks (MIL/Fe-100) through chelation interaction. The resulting nanocomplex (MC) not only enhances the bioavailability of CHA but also facilitates a synergistic antioxidant effect between CHA and MIL/Fe-100. Importantly, CHA can chelate Zn2+ from β-amyloid/Zn2+ (Aβ/Zn2+) polymers, inhibiting Aβ aggregation. Furthermore, small interfering RNA targeting BACE1 was covalently linked to MC to downregulate BACE1 expression. Both in vitro and in vivo experiments revealed that MC-H/R/si effectively scavenges ROS, reduces inflammation and Aβ plaque, and improves the learning and cognitive abilities of APP/PS1 mice. These findings confirm that the trifunctional nanocarrier MC-H/R/si has great potential for AD treatment.http://www.sciencedirect.com/science/article/pii/S2590006425004016Alzheimer's diseaseMIL/Fe-100Chlorogenic acidAnti-inflammatoryGene silenceBACE1 |
| spellingShingle | Chenchen Wang Xiaolei Song Xiaowan Zhang Peng Li Wei Wei Shihao Sun Yong Chen Multifunctional natural chlorogenic acid based nanocarrier for Alzheimer's disease treatment Materials Today Bio Alzheimer's disease MIL/Fe-100 Chlorogenic acid Anti-inflammatory Gene silence BACE1 |
| title | Multifunctional natural chlorogenic acid based nanocarrier for Alzheimer's disease treatment |
| title_full | Multifunctional natural chlorogenic acid based nanocarrier for Alzheimer's disease treatment |
| title_fullStr | Multifunctional natural chlorogenic acid based nanocarrier for Alzheimer's disease treatment |
| title_full_unstemmed | Multifunctional natural chlorogenic acid based nanocarrier for Alzheimer's disease treatment |
| title_short | Multifunctional natural chlorogenic acid based nanocarrier for Alzheimer's disease treatment |
| title_sort | multifunctional natural chlorogenic acid based nanocarrier for alzheimer s disease treatment |
| topic | Alzheimer's disease MIL/Fe-100 Chlorogenic acid Anti-inflammatory Gene silence BACE1 |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425004016 |
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