Functional network differences between unilateral and bilateral deep brain stimulation of the subthalamic nucleus

Functional network differences between unilateral and bilateral deep brain stimulation of the subthalamic nucleus

Abstract Unilateral versus bilateral implantation is a critical surgical consideration for deep brain stimulation in Parkinson’s disease; however, the differing therapeutic effects remain incompletely understood. Using functional magnetic resonance imaging during active stimulation, we show that bil...

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Main Authors: Brendan Santyr, Alexandre Boutet, Mohamad Abbass, Artur Vetkas, Jürgen Germann, Afis Ajala, Jianwei Qiu, Gavin J. B. Elias, Can Sarica, Andrew Z. Yang, Ibrahim Alhashyan, Suneil K. Kalia, Alfonso Fasano, Andres M. Lozano
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-01064-2
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Summary:Abstract Unilateral versus bilateral implantation is a critical surgical consideration for deep brain stimulation in Parkinson’s disease; however, the differing therapeutic effects remain incompletely understood. Using functional magnetic resonance imaging during active stimulation, we show that bilateral stimulation reinforces the recruitment of key motor hubs while reducing non-motor responses seen with unilateral stimulation and correlates with improved outcomes. This suggests a potential mechanistic basis for better motor function following bilateral stimulation.
ISSN:2373-8057

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