Causal Links Between Bone Diseases and Temporomandibular Disorders
Introduction and Aims: Epidemiological observational studies have explored the link between bone joint-related diseases and temporomandibular disorders (TMD), but inconsistent conclusions have emerged due to various limitations. This study aims to investigate the causal relationship between bone joi...
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Elsevier
2025-06-01
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| Series: | International Dental Journal |
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| author | Ling Zhang Qinghua Zhang Dong Zhao |
| author_facet | Ling Zhang Qinghua Zhang Dong Zhao |
| author_sort | Ling Zhang |
| collection | DOAJ |
| description | Introduction and Aims: Epidemiological observational studies have explored the link between bone joint-related diseases and temporomandibular disorders (TMD), but inconsistent conclusions have emerged due to various limitations. This study aims to investigate the causal relationship between bone joint-related diseases and TMD using Mendelian randomization (MR). Methods: We utilized a two-sample MR design, applying pooled genome-wide association study (GWAS) data from six subtypes of bone and joint diseases and TMD. Primary analysis was conducted using the inverse-variance weighted (IVW) method, complemented by weighted median (WM), weighted mode, and MR-Egger regression to assess causal relationships. Additionally, we performed reverse causality analyses and applied sensitivity analyses, including MR-PRESSO, MR-Egger, Cochran's Q, and leave-one-out methods to evaluate result robustness, explore heterogeneity, and identify potential biases. Results: MR genetic prediction analyses indicated that bone and joint-related diseases increase the risk of TMD, with specific odds ratios (OR) for ankylosing spondylitis (AS: OR 1.36, 95% CI: 1.04-1.77, P = .026), rheumatoid arthritis (RA: OR 1.08, 95% CI: 1.03-1.13, P = .001), and osteoporosis (OR 1.0751, 95% CI: 1.0047-1.1505, P = .036). Conversely, reverse MR analysis revealed a positive genetic link from TMD to RA (RA: OR 1.12, 95% CI: 1.02-1.23, P = .018). MR-Egger regression showed no influence of horizontal pleiotropy, and MR-PRESSO detected no outliers. The leave-one-out analysis confirmed the results' stability. Conclusions: The findings demonstrate a positive, causal association between TMD risk and AS, RA, and osteoporosis. Moreover, TMD patients exhibit an increased risk of developing RA. Clinical Relevance: Understanding these relationships aids in better diagnosis and management of TMD and its association with bone joint diseases, potentially guiding clinical interventions. |
| format | Article |
| id | doaj-art-7f207113fdaf4ae282add2fa45708a14 |
| institution | Kabale University |
| issn | 0020-6539 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Dental Journal |
| spelling | doaj-art-7f207113fdaf4ae282add2fa45708a142025-08-20T03:49:03ZengElsevierInternational Dental Journal0020-65392025-06-017531951196010.1016/j.identj.2025.01.010Causal Links Between Bone Diseases and Temporomandibular DisordersLing Zhang0Qinghua Zhang1Dong Zhao2Department of Oral and Maxillofacial Surgery, Shanxi Provincial People's Hospital, Taiyuan, 030001, Shanxi, China; Corresponding author. Department of Oral and Maxillofacial Surgery, Shanxi Provincial People's Hospital. No. 29 Shuangtasi Street, Taiyuan, 030001, Shanxi, China.Department of Orthodontics, Shanxi Provincial People's Hospital, Taiyuan, 030001, Shanxi, ChinaDepartment of Prosthodontics, Taiyuan Conatant lun Dental Hospital, Taiyuan, 030001, Shanxi, ChinaIntroduction and Aims: Epidemiological observational studies have explored the link between bone joint-related diseases and temporomandibular disorders (TMD), but inconsistent conclusions have emerged due to various limitations. This study aims to investigate the causal relationship between bone joint-related diseases and TMD using Mendelian randomization (MR). Methods: We utilized a two-sample MR design, applying pooled genome-wide association study (GWAS) data from six subtypes of bone and joint diseases and TMD. Primary analysis was conducted using the inverse-variance weighted (IVW) method, complemented by weighted median (WM), weighted mode, and MR-Egger regression to assess causal relationships. Additionally, we performed reverse causality analyses and applied sensitivity analyses, including MR-PRESSO, MR-Egger, Cochran's Q, and leave-one-out methods to evaluate result robustness, explore heterogeneity, and identify potential biases. Results: MR genetic prediction analyses indicated that bone and joint-related diseases increase the risk of TMD, with specific odds ratios (OR) for ankylosing spondylitis (AS: OR 1.36, 95% CI: 1.04-1.77, P = .026), rheumatoid arthritis (RA: OR 1.08, 95% CI: 1.03-1.13, P = .001), and osteoporosis (OR 1.0751, 95% CI: 1.0047-1.1505, P = .036). Conversely, reverse MR analysis revealed a positive genetic link from TMD to RA (RA: OR 1.12, 95% CI: 1.02-1.23, P = .018). MR-Egger regression showed no influence of horizontal pleiotropy, and MR-PRESSO detected no outliers. The leave-one-out analysis confirmed the results' stability. Conclusions: The findings demonstrate a positive, causal association between TMD risk and AS, RA, and osteoporosis. Moreover, TMD patients exhibit an increased risk of developing RA. Clinical Relevance: Understanding these relationships aids in better diagnosis and management of TMD and its association with bone joint diseases, potentially guiding clinical interventions.http://www.sciencedirect.com/science/article/pii/S0020653925000176Mendelian randomizationInstrumental variablesTemporomandibular disorders (TMD)Ankylosing spondylitis (AS)Rheumatoid arthritis (RA)Osteoporosis |
| spellingShingle | Ling Zhang Qinghua Zhang Dong Zhao Causal Links Between Bone Diseases and Temporomandibular Disorders International Dental Journal Mendelian randomization Instrumental variables Temporomandibular disorders (TMD) Ankylosing spondylitis (AS) Rheumatoid arthritis (RA) Osteoporosis |
| title | Causal Links Between Bone Diseases and Temporomandibular Disorders |
| title_full | Causal Links Between Bone Diseases and Temporomandibular Disorders |
| title_fullStr | Causal Links Between Bone Diseases and Temporomandibular Disorders |
| title_full_unstemmed | Causal Links Between Bone Diseases and Temporomandibular Disorders |
| title_short | Causal Links Between Bone Diseases and Temporomandibular Disorders |
| title_sort | causal links between bone diseases and temporomandibular disorders |
| topic | Mendelian randomization Instrumental variables Temporomandibular disorders (TMD) Ankylosing spondylitis (AS) Rheumatoid arthritis (RA) Osteoporosis |
| url | http://www.sciencedirect.com/science/article/pii/S0020653925000176 |
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