S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation

S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation

BackgroundSphingosine-1-phosphate (S1P) and its five receptors S1PR1-5 play an essential role in the migration, differentiation and activation of various immune cells. Several S1PR modulators with distinct selectivity have been recently approved for the treatment of various inflammatory diseases. Am...

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Bibliographic Details
Main Authors: Fiona K. Sailer, Megan A. Palmer, Blerina Aliraj, Jan Heering, Andreas Brockmann, Mohammed A. F. Elewa, Aissa Röhrig, Ewgenij Proschak, Dariusz T. Stepniak, Simeon Ramsey, Bernhard Brüne, Andreas Weigert
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
Sphingosine-1-phosphate
S1P receptor modulator
S1PR4
Etrasimod
inflammatory bowel disease
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1590816/full
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