Study of Expression of <i>MST3</i> in Myeloid Leukaemia
Myeloid leukaemia (ML) is a cancer that occurs by the accumulation of abnormally multiplied myeloid cells in bone marrow, peripheral blood, and other related tissue. <i>MST3</i> is a gene of the GCK family that has a role in apoptosis, along with other cellular functions like cellular di...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
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| Series: | Medical Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3271/13/2/33 |
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| Summary: | Myeloid leukaemia (ML) is a cancer that occurs by the accumulation of abnormally multiplied myeloid cells in bone marrow, peripheral blood, and other related tissue. <i>MST3</i> is a gene of the GCK family that has a role in apoptosis, along with other cellular functions like cellular differentiation, cell cycle, metabolism, and others. Objectives: The objectives of this study were to count RBCs and WBCs, study <i>MST3</i> expression in ML and control samples, and perform an in silico correlation study on the <i>KRAS</i> and <i>NRAS</i> genes. Methods: The counting of RBCs and WBCs was carried out using a hemacytometer, the expression of <i>MST3</i> was studied using RT-PCR, and a correlation study was carried out using GEPIA. Results: RBC and WBC levels in ML differed from the control levels, and the expression of <i>MST3</i> was found to be upregulated in ML in comparison to controls, with a 2.90–8.65-fold change, with a significant <i>p</i>-value > 0.05. A positive correlation in expression was also found between <i>MST3</i> and <i>KRAS</i> and <i>NRAS</i> genes, with a significant r value correlation. Conclusions: From this study, it could be deduced that <i>MST3</i> might have a role in ML pathogenesis, but further research is needed to study its role in the progression of the disease. |
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| ISSN: | 2076-3271 |