Vitamin D on the susceptibility of gestational diabetes mellitus: a mini-review
Gestational diabetes mellitus (GDM), which refers to diabetes mellitus or abnormal glucose tolerance of any degree occurring during pregnancy, is a distinct type within the diabetes classification. 25-hydroxyvitamin D deficiency has been associated with an increased risk of maternal glycaemia, insul...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1514148/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832557383851704320 |
|---|---|
| author | Ting Zhang Ting Zhang Lan Yang Shuman Yang Song Gao |
| author_facet | Ting Zhang Ting Zhang Lan Yang Shuman Yang Song Gao |
| author_sort | Ting Zhang |
| collection | DOAJ |
| description | Gestational diabetes mellitus (GDM), which refers to diabetes mellitus or abnormal glucose tolerance of any degree occurring during pregnancy, is a distinct type within the diabetes classification. 25-hydroxyvitamin D deficiency has been associated with an increased risk of maternal glycaemia, insulin resistance and gestational diabetes. There is no consensus on the definition of vitamin D deficiency, but most scientists define vitamin D deficiency as less than 20 ng/mL (50 nmoL/L) of 25-hydroxyvitamin D. Vitamin D deficiency is common in women during pregnancy. Vitamin D can regulate the course of gestational diabetes, which may be related to regulation of insulin gene transcription, insulin secretion, intracellular and cytosolic calcium balance, inhibition of oxidative stress and inflammatory responses and alteration of glucose metabolism. This is a review article that aims to analyze the possible mechanism of vitamin D regulation of GDM, which provides a theoretical basis for clinical researchers in the future management of patients with GDM. |
| format | Article |
| id | doaj-art-7f17d0fde089453c8e75d6a0d9e2a09d |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-7f17d0fde089453c8e75d6a0d9e2a09d2025-02-03T05:11:55ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-02-011210.3389/fnut.2025.15141481514148Vitamin D on the susceptibility of gestational diabetes mellitus: a mini-reviewTing Zhang0Ting Zhang1Lan Yang2Shuman Yang3Song Gao4College of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua, ChinaUniversity Hospital, Zhejiang Normal University, Jinhua, ChinaSchool of Mathematical Sciences, Zhejiang Normal University, Jinhua, ChinaCollege of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua, ChinaCollege of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua, ChinaGestational diabetes mellitus (GDM), which refers to diabetes mellitus or abnormal glucose tolerance of any degree occurring during pregnancy, is a distinct type within the diabetes classification. 25-hydroxyvitamin D deficiency has been associated with an increased risk of maternal glycaemia, insulin resistance and gestational diabetes. There is no consensus on the definition of vitamin D deficiency, but most scientists define vitamin D deficiency as less than 20 ng/mL (50 nmoL/L) of 25-hydroxyvitamin D. Vitamin D deficiency is common in women during pregnancy. Vitamin D can regulate the course of gestational diabetes, which may be related to regulation of insulin gene transcription, insulin secretion, intracellular and cytosolic calcium balance, inhibition of oxidative stress and inflammatory responses and alteration of glucose metabolism. This is a review article that aims to analyze the possible mechanism of vitamin D regulation of GDM, which provides a theoretical basis for clinical researchers in the future management of patients with GDM.https://www.frontiersin.org/articles/10.3389/fnut.2025.1514148/fullvitamin Dgestational diabetesinsulin resistancetreatmentprevention |
| spellingShingle | Ting Zhang Ting Zhang Lan Yang Shuman Yang Song Gao Vitamin D on the susceptibility of gestational diabetes mellitus: a mini-review Frontiers in Nutrition vitamin D gestational diabetes insulin resistance treatment prevention |
| title | Vitamin D on the susceptibility of gestational diabetes mellitus: a mini-review |
| title_full | Vitamin D on the susceptibility of gestational diabetes mellitus: a mini-review |
| title_fullStr | Vitamin D on the susceptibility of gestational diabetes mellitus: a mini-review |
| title_full_unstemmed | Vitamin D on the susceptibility of gestational diabetes mellitus: a mini-review |
| title_short | Vitamin D on the susceptibility of gestational diabetes mellitus: a mini-review |
| title_sort | vitamin d on the susceptibility of gestational diabetes mellitus a mini review |
| topic | vitamin D gestational diabetes insulin resistance treatment prevention |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1514148/full |
| work_keys_str_mv | AT tingzhang vitamindonthesusceptibilityofgestationaldiabetesmellitusaminireview AT tingzhang vitamindonthesusceptibilityofgestationaldiabetesmellitusaminireview AT lanyang vitamindonthesusceptibilityofgestationaldiabetesmellitusaminireview AT shumanyang vitamindonthesusceptibilityofgestationaldiabetesmellitusaminireview AT songgao vitamindonthesusceptibilityofgestationaldiabetesmellitusaminireview |