A novel small molecule that enhances lysyl hydroxylase 2 activity and matrix mineralization

A novel small molecule that enhances lysyl hydroxylase 2 activity and matrix mineralization

Lysyl hydroxylase 2 (LH2), encoded by the procollagen lysine 2-oxoglutarate 5-dioxygenase 2 (Plod2) gene, catalyzes the hydroxylation of lysine residues in the fibrillar collagen telopeptides. This post-translational modification is essential for forming the stable hydroxylysine-aldehyde derived col...

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Bibliographic Details
Main Authors: Saori Tomiku, Atsushi Kasamatsu, Reo Fukushima, Tomoaki Saito, Ryunosuke Nozaki, Akiko Suganami, Yutaka Tamura, Mitsuo Yamauchi, Katsuhiro Uzawa
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Biochemistry and Biophysics Reports
Subjects:
Lysyl hydroxylase 2
In silico docking simulations
Small molecule
Bone mineralization
Collagen cross-link
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580825001402
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