Therapeutic Implications of PPARγ in Cardiovascular Diseases
Peroxisome proliferator-activated receptor-γ (PPARγ) is the members of the nuclear receptor superfamily as a master transcriptional factor that promotes differentiation of preadipocytes by activating adipose-specific gene expression. Although PPARγ is expressed predominantly in adipose tissue and as...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2010/876049 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549588015251456 |
|---|---|
| author | Hiroshi Hasegawa Hiroyuki Takano Issei Komuro |
| author_facet | Hiroshi Hasegawa Hiroyuki Takano Issei Komuro |
| author_sort | Hiroshi Hasegawa |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptor-γ (PPARγ) is the members of the nuclear receptor superfamily as a master transcriptional factor that promotes differentiation of preadipocytes by activating adipose-specific gene expression. Although PPARγ is expressed predominantly in adipose tissue and associated with adipocyte differentiation and glucose homeostasis, PPARγ is also present in a variety of cell types including vascular cells and cardiomyocytes. Activation of PPARγ suppresses production of inflammatory cytokines, and there is accumulating data that PPARγ ligands exert antihypertrophy of cardiomyocytes and anti-inflammatory, antioxidative, and antiproliferative effects on vascular wall cells and cardiomyocytes. In addition, activation of PPARγ is implicated in the regulation of endothelial function, proliferation and migration of vascular smooth muscle cells, and activation of macrophages. Many studies suggest that PPARγ ligands not only ameliorate insulin sensitivity, but also have pleiotropic effects on the pathophysiology of atherosclerosis, cardiac hypertrophy, ischemic heart, and myocarditis. |
| format | Article |
| id | doaj-art-7f13c0e9ee9a4dc1bf491f8b3f258898 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-7f13c0e9ee9a4dc1bf491f8b3f2588982025-02-03T06:11:00ZengWileyPPAR Research1687-47571687-47652010-01-01201010.1155/2010/876049876049Therapeutic Implications of PPARγ in Cardiovascular DiseasesHiroshi Hasegawa0Hiroyuki Takano1Issei Komuro2Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDepartment of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanDepartment of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanPeroxisome proliferator-activated receptor-γ (PPARγ) is the members of the nuclear receptor superfamily as a master transcriptional factor that promotes differentiation of preadipocytes by activating adipose-specific gene expression. Although PPARγ is expressed predominantly in adipose tissue and associated with adipocyte differentiation and glucose homeostasis, PPARγ is also present in a variety of cell types including vascular cells and cardiomyocytes. Activation of PPARγ suppresses production of inflammatory cytokines, and there is accumulating data that PPARγ ligands exert antihypertrophy of cardiomyocytes and anti-inflammatory, antioxidative, and antiproliferative effects on vascular wall cells and cardiomyocytes. In addition, activation of PPARγ is implicated in the regulation of endothelial function, proliferation and migration of vascular smooth muscle cells, and activation of macrophages. Many studies suggest that PPARγ ligands not only ameliorate insulin sensitivity, but also have pleiotropic effects on the pathophysiology of atherosclerosis, cardiac hypertrophy, ischemic heart, and myocarditis.http://dx.doi.org/10.1155/2010/876049 |
| spellingShingle | Hiroshi Hasegawa Hiroyuki Takano Issei Komuro Therapeutic Implications of PPARγ in Cardiovascular Diseases PPAR Research |
| title | Therapeutic Implications of PPARγ in Cardiovascular Diseases |
| title_full | Therapeutic Implications of PPARγ in Cardiovascular Diseases |
| title_fullStr | Therapeutic Implications of PPARγ in Cardiovascular Diseases |
| title_full_unstemmed | Therapeutic Implications of PPARγ in Cardiovascular Diseases |
| title_short | Therapeutic Implications of PPARγ in Cardiovascular Diseases |
| title_sort | therapeutic implications of pparγ in cardiovascular diseases |
| url | http://dx.doi.org/10.1155/2010/876049 |
| work_keys_str_mv | AT hiroshihasegawa therapeuticimplicationsofppargincardiovasculardiseases AT hiroyukitakano therapeuticimplicationsofppargincardiovasculardiseases AT isseikomuro therapeuticimplicationsofppargincardiovasculardiseases |