Treatment efficacy for infantile epileptic spasms syndrome in children with trisomy 21

Treatment efficacy for infantile epileptic spasms syndrome in children with trisomy 21

BackgroundInfantile Epileptic Spasms Syndrome (IESS) is the most common epilepsy syndrome in children with trisomy 21. First-line standard treatments for IESS include adrenocorticotropic hormone (ACTH), oral corticosteroids, and vigabatrin. Among children with trisomy 21 and IESS, treatment with ACT...

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Main Authors:	Henry Chen, Adam L. Numis, Renée A. Shellhaas, John R. Mytinger, Debopam Samanta, Rani K. Singh, Shaun A. Hussain, Danielle Takacs, Kelly G. Knupp, Li-Rong Shao, Carl E. Stafstrom
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Series:	Frontiers in Pediatrics
Subjects:	infantile spasms infantile epileptic spasms syndrome Down syndrome trisomy 21 anti-seizure medications hypsarrhythmia
Online Access:	https://www.frontiersin.org/articles/10.3389/fped.2025.1498425/full
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