Comparison of the effect of desloratadine and montelukast combined treatment with desloratadine monotherapy on clinical symptoms and quality of life of patients with persistent allergic rhinitis
Background and Aim: Allergic rhinitis is the most common atopic disorder and a chronic inflammatory disease of the airways, which can lead to disruption and decrease the patient's quality of life in the long term. This study was conducted to compare the effects of desloratadine and montelukast...
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Kashan University of Medical Sciences
2023-12-01
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| Series: | مجله علوم پزشکی فیض (پیوسته) |
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| Online Access: | http://feyz.kaums.ac.ir/article-1-5001-en.pdf |
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| author | Meghdad Rahati Amir hossein Ahsaniarani Shayan Ramezanpour Saeed Amini |
| author_facet | Meghdad Rahati Amir hossein Ahsaniarani Shayan Ramezanpour Saeed Amini |
| author_sort | Meghdad Rahati |
| collection | DOAJ |
| description | Background and Aim: Allergic rhinitis is the most common atopic disorder and a chronic inflammatory disease of the airways, which can lead to disruption and decrease the patient's quality of life in the long term. This study was conducted to compare the effects of desloratadine and montelukast combined treatment with desloratadine monotherapy on clinical symptoms and quality of life of patients with persistent allergic rhinitis.
Methods: This double-blind controlled clinical trial was conducted in the Ear, Nose and Throat Clinic of Metini Medical Training Center affiliated to Kashan University of Medical Sciences, on 56 patients with persistent allergic rhinitis. Patients were randomly assigned into two groups to receive combined treatment of montelukast (10 mg) and desloratadine (5 mg daily) or single drug treatment of desloratadine for a period of 6 weeks. At the beginning and end of the study, the quality of life and severity of clinical symptoms were evaluated by completing the miniRQLQ questionnaire and nasal symptom score in both groups.
Results: In the intervention group (combined treatment of montelukast and desloratadine) and the control group (single drug treatment of desloratadine), the quality of life increased significantly after receiving the treatment compared to before (P<0.05), although in the intervention group, this increase was more than that in the control group. Moreover, the intensity of clinical symptoms decreased significantly after receiving the treatment compared to before (P<0.01), although this reduction was more in the intervention group.
Conclusion: It can be concluded that in patients with stable allergic rhinitis, the combined treatment of montelukast and desloratadine and the single drug treatment of desloratadine are effective in improving the quality of life and reducing the severity of clinical symptoms. |
| format | Article |
| id | doaj-art-7f10f4450de346b6aee5c0c3d2bbd73c |
| institution | OA Journals |
| issn | 3060-5806 3060-5814 |
| language | fas |
| publishDate | 2023-12-01 |
| publisher | Kashan University of Medical Sciences |
| record_format | Article |
| series | مجله علوم پزشکی فیض (پیوسته) |
| spelling | doaj-art-7f10f4450de346b6aee5c0c3d2bbd73c2025-08-20T02:26:14ZfasKashan University of Medical Sciencesمجله علوم پزشکی فیض (پیوسته)3060-58063060-58142023-12-01275512520Comparison of the effect of desloratadine and montelukast combined treatment with desloratadine monotherapy on clinical symptoms and quality of life of patients with persistent allergic rhinitisMeghdad Rahati0Amir hossein Ahsaniarani1Shayan Ramezanpour2Saeed Amini3 Department of Healthcare Management, Khomein University of Medical Sciences, Khomein, Iran Department of Otorhinolaryngology, Kashan University of Medical Sciences, Kashan, Iran Physician, Kashan University of Medical Sciences, Kashan, Iran Department of Healthcare Management, Khomein University of Medical Sciences, Kashan, Iran Background and Aim: Allergic rhinitis is the most common atopic disorder and a chronic inflammatory disease of the airways, which can lead to disruption and decrease the patient's quality of life in the long term. This study was conducted to compare the effects of desloratadine and montelukast combined treatment with desloratadine monotherapy on clinical symptoms and quality of life of patients with persistent allergic rhinitis. Methods: This double-blind controlled clinical trial was conducted in the Ear, Nose and Throat Clinic of Metini Medical Training Center affiliated to Kashan University of Medical Sciences, on 56 patients with persistent allergic rhinitis. Patients were randomly assigned into two groups to receive combined treatment of montelukast (10 mg) and desloratadine (5 mg daily) or single drug treatment of desloratadine for a period of 6 weeks. At the beginning and end of the study, the quality of life and severity of clinical symptoms were evaluated by completing the miniRQLQ questionnaire and nasal symptom score in both groups. Results: In the intervention group (combined treatment of montelukast and desloratadine) and the control group (single drug treatment of desloratadine), the quality of life increased significantly after receiving the treatment compared to before (P<0.05), although in the intervention group, this increase was more than that in the control group. Moreover, the intensity of clinical symptoms decreased significantly after receiving the treatment compared to before (P<0.01), although this reduction was more in the intervention group. Conclusion: It can be concluded that in patients with stable allergic rhinitis, the combined treatment of montelukast and desloratadine and the single drug treatment of desloratadine are effective in improving the quality of life and reducing the severity of clinical symptoms.http://feyz.kaums.ac.ir/article-1-5001-en.pdfpersistent allergic rhinitiscombined treatmentquality of lifemontelukastdesloratadine |
| spellingShingle | Meghdad Rahati Amir hossein Ahsaniarani Shayan Ramezanpour Saeed Amini Comparison of the effect of desloratadine and montelukast combined treatment with desloratadine monotherapy on clinical symptoms and quality of life of patients with persistent allergic rhinitis مجله علوم پزشکی فیض (پیوسته) persistent allergic rhinitis combined treatment quality of life montelukast desloratadine |
| title | Comparison of the effect of desloratadine and montelukast combined treatment with desloratadine monotherapy on clinical symptoms and quality of life of patients with persistent allergic rhinitis |
| title_full | Comparison of the effect of desloratadine and montelukast combined treatment with desloratadine monotherapy on clinical symptoms and quality of life of patients with persistent allergic rhinitis |
| title_fullStr | Comparison of the effect of desloratadine and montelukast combined treatment with desloratadine monotherapy on clinical symptoms and quality of life of patients with persistent allergic rhinitis |
| title_full_unstemmed | Comparison of the effect of desloratadine and montelukast combined treatment with desloratadine monotherapy on clinical symptoms and quality of life of patients with persistent allergic rhinitis |
| title_short | Comparison of the effect of desloratadine and montelukast combined treatment with desloratadine monotherapy on clinical symptoms and quality of life of patients with persistent allergic rhinitis |
| title_sort | comparison of the effect of desloratadine and montelukast combined treatment with desloratadine monotherapy on clinical symptoms and quality of life of patients with persistent allergic rhinitis |
| topic | persistent allergic rhinitis combined treatment quality of life montelukast desloratadine |
| url | http://feyz.kaums.ac.ir/article-1-5001-en.pdf |
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