Transglutaminase 2 Prevents Premature Senescence and Promotes Osteoblastic Differentiation of Mesenchymal Stem Cells through NRF2 Activation

Transglutaminase 2 Prevents Premature Senescence and Promotes Osteoblastic Differentiation of Mesenchymal Stem Cells through NRF2 Activation

Transglutaminase 2 (TG2) is a multifunctional enzyme that exhibits transamidase, GTPase, kinase, and protein disulfide isomerase (PDI) activities. Of these, transamidase-mediated modification of proteins regulates apoptosis, differentiation, inflammation, and fibrosis. TG2 is highly expressed in mes...

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Bibliographic Details
Main Authors:	Soo-Jin Lee, Ji-Woong Shin, Mee-Ae Kwon, Ki Baek Lee, Hyo-Jun Kim, Jin-Haeng Lee, Heun-Soo Kang, Jong Kwan Jun, Sung-Yup Cho, In-Gyu Kim
Format:	Article
Language:	English
Published:	Wiley 2023-01-01
Series:	Stem Cells International
Online Access:	http://dx.doi.org/10.1155/2023/8815888
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