Riluzole’s role in treatment of spinal cord injuries – overview of studies on animals and humans
Injuries in the spinal cord are responsible for disabling a great number of people each year. The primary and secondary damage varies in pathomechanisms, the latter one being heavily associated with excitotoxicity caused by excess extracellular glutamate. Riluzole, a drug used in amyotrophic latera...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2025-05-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/60023 |
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| author | Wenancjusz Stołowski Natalia Rulewska Filip Grabowski Jakub Siemko Dagmara Neska Dominika Prystacka-Szar Justyna Stadler-Szajda Adrianna Czyżnikiewicz Magdalena Bujak Magdalena Waśniowska |
| author_facet | Wenancjusz Stołowski Natalia Rulewska Filip Grabowski Jakub Siemko Dagmara Neska Dominika Prystacka-Szar Justyna Stadler-Szajda Adrianna Czyżnikiewicz Magdalena Bujak Magdalena Waśniowska |
| author_sort | Wenancjusz Stołowski |
| collection | DOAJ |
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Injuries in the spinal cord are responsible for disabling a great number of people each year. The primary and secondary damage varies in pathomechanisms, the latter one being heavily associated with excitotoxicity caused by excess extracellular glutamate. Riluzole, a drug used in amyotrophic lateral sclerosis, lowers the amount of released glutamate, thus making it a possible candidate for treatment in spinal cord injuries. Several studies have been performed on animals and humans, although their results do not always align. In controlled environments, when injuries to the neural tissue in the spinal cord are mechanical or ischemic, the drug’s usage shows promising effects in treated rats. Tests on humans are much harder to conduct and so the research has focused on already ill individuals. Their conditions vary, however, and not all of the people could recover, even to a small degree. Further studies need to be performed in order to qualify riluzole as a remedium to injuries of the spinal cord.
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| format | Article |
| id | doaj-art-7f0585fe03d8463486d8fd3fbe8d432a |
| institution | OA Journals |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-7f0585fe03d8463486d8fd3fbe8d432a2025-08-20T02:15:12ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-05-018010.12775/JEHS.2025.80.60023Riluzole’s role in treatment of spinal cord injuries – overview of studies on animals and humansWenancjusz Stołowski0https://orcid.org/0009-0009-0317-1212Natalia Rulewska1https://orcid.org/0009-0008-4515-7403Filip Grabowski2https://orcid.org/0009-0007-0466-2764Jakub Siemko3https://orcid.org/0009-0009-9318-9458Dagmara Neska4https://orcid.org/0009-0003-1900-954XDominika Prystacka-Szar5https://orcid.org/0009-0003-6533-4247Justyna Stadler-Szajda6https://orcid.org/0000-0002-1742-1835Adrianna Czyżnikiewicz7https://orcid.org/0009-0007-4541-7175Magdalena Bujak8https://orcid.org/0009-0008-9274-3595Magdalena Waśniowska9https://orcid.org/0009-0006-0614-8307Ludwika Błażka Provincial Multi-Specialist Hospital in Inowrocław: Inowrocław, PLProvincial Specialist Hospital in Ciechanów St. Powstańców Wielkopolskich 2, 06-400 Ciechanów, PolandProvincial Specialist Hospital in Ciechanów St. Powstańców Wielkopolskich 2, 06-400 Ciechanów, PolandLudwika Błażka Provincial Multi-Specialist Hospital in Inowrocław St. Poznańska 97, 88-100 InowrocławLudwika Błażka Provincial Multi-Specialist Hospital in Inowrocław St. Poznańska 97, 88-100 Inowrocław,PLLudwik Rydygier Memorial Specialized Hospital in Krakow Osiedle Złotej Jesieni 1, 31-820 KrakówLudwika Błażka Provincial Multi-Specialist Hospital in Inowrocław St. Poznańska 97, 88-100 InowrocławLudwika Błażka Provincial Multi-Specialist Hospital in Inowrocław St. Poznańska 97, 88-100 InowrocławKrakow University Hospital St. Macieja Jakubowskiego 2, 30-688 Krakow Stefana Żeromskiego Specialist Hospital in Kraków Os. Na Skarpie 66, 31-913 Kraków Injuries in the spinal cord are responsible for disabling a great number of people each year. The primary and secondary damage varies in pathomechanisms, the latter one being heavily associated with excitotoxicity caused by excess extracellular glutamate. Riluzole, a drug used in amyotrophic lateral sclerosis, lowers the amount of released glutamate, thus making it a possible candidate for treatment in spinal cord injuries. Several studies have been performed on animals and humans, although their results do not always align. In controlled environments, when injuries to the neural tissue in the spinal cord are mechanical or ischemic, the drug’s usage shows promising effects in treated rats. Tests on humans are much harder to conduct and so the research has focused on already ill individuals. Their conditions vary, however, and not all of the people could recover, even to a small degree. Further studies need to be performed in order to qualify riluzole as a remedium to injuries of the spinal cord. https://apcz.umk.pl/JEHS/article/view/60023RiluzoleSpinal Cord Injury (SCI)Glutamate |
| spellingShingle | Wenancjusz Stołowski Natalia Rulewska Filip Grabowski Jakub Siemko Dagmara Neska Dominika Prystacka-Szar Justyna Stadler-Szajda Adrianna Czyżnikiewicz Magdalena Bujak Magdalena Waśniowska Riluzole’s role in treatment of spinal cord injuries – overview of studies on animals and humans Journal of Education, Health and Sport Riluzole Spinal Cord Injury (SCI) Glutamate |
| title | Riluzole’s role in treatment of spinal cord injuries – overview of studies on animals and humans |
| title_full | Riluzole’s role in treatment of spinal cord injuries – overview of studies on animals and humans |
| title_fullStr | Riluzole’s role in treatment of spinal cord injuries – overview of studies on animals and humans |
| title_full_unstemmed | Riluzole’s role in treatment of spinal cord injuries – overview of studies on animals and humans |
| title_short | Riluzole’s role in treatment of spinal cord injuries – overview of studies on animals and humans |
| title_sort | riluzole s role in treatment of spinal cord injuries overview of studies on animals and humans |
| topic | Riluzole Spinal Cord Injury (SCI) Glutamate |
| url | https://apcz.umk.pl/JEHS/article/view/60023 |
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