Prion protein-specific antibodies that detect multiple TSE agents with high sensitivity.

Prion protein-specific antibodies that detect multiple TSE agents with high sensitivity.

This paper describes the generation, characterisation and potential applications of a panel of novel anti-prion protein monoclonal antibodies (mAbs). The mAbs were generated by immunising PRNP null mice, using a variety of regimes, with a truncated form of recombinant ovine prion protein spanning re...

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Bibliographic Details
Main Authors: Sandra McCutcheon, Jan P M Langeveld, Boon Chin Tan, Andrew C Gill, Christopher de Wolf, Stuart Martin, Lorenzo Gonzalez, James Alibhai, A Richard Alejo Blanco, Lauren Campbell, Nora Hunter, E Fiona Houston
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0091143
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