Corpus callosum and cerebellar vermis size in very preterm infants: Relationship to long-term neurodevelopmental outcome
Background: The neonatal changes of corpus callosum or cerebellar volume in preterm infants have been shown to link with abnormal mentality and motor disability in early childhood. This study aims to predict the long-term neurological outcomes by measuring these changes on neonatal brain ultrasound...
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Elsevier
2019-04-01
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| Series: | Pediatrics and Neonatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957217305466 |
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| author | Po-Ming Wu Hsin-I. Shih Wen-Hao Yu Li-Wen Chen Lie-Chuan Wang Chao-Ching Huang Yi-Fang Tu |
| author_facet | Po-Ming Wu Hsin-I. Shih Wen-Hao Yu Li-Wen Chen Lie-Chuan Wang Chao-Ching Huang Yi-Fang Tu |
| author_sort | Po-Ming Wu |
| collection | DOAJ |
| description | Background: The neonatal changes of corpus callosum or cerebellar volume in preterm infants have been shown to link with abnormal mentality and motor disability in early childhood. This study aims to predict the long-term neurological outcomes by measuring these changes on neonatal brain ultrasound in preterm infants. Methods: Our cohort consisted of infants aged below 32 weeks' gestation with very low birth body weights who completed neuro-assessments at 5 years of age. Corpus callosum or cerebellar vermis were measured at 28–30 weeks and at 37–40 weeks gestational age in premature infants with cerebral palsy (CP), mental retardation (MR) and normal control premature infants. Results: There are 12 patients in MR group, 12 in CP group and 27 patients as controls for final analysis. There was no significant difference in other factors between study groups except lower gestational age (P = 0.043) in CP group. Respiratory distress syndrome was more common in MR group (P = 0.037) and cystic periventricular leukomalacia was more common in CP group (P < 0.001) than controls. After adjusting for sex and birth body weight, the MR group had smaller cerebellar vermis area at 37–40 gestational weeks (P = 0.002) than controls. They also reduced the growth of corpus callosum area (difference = −0.12 ± 0.16, P = 0.029) and cerebellar vermis area (difference = 1.10 ± 0.44, P = 0.020) from 28 to 30 gestational weeks to 37–40 gestational weeks compared with controls (difference = 0.03 ± 0.15, 1.92 ± 0.70, respectively). In contrast, the CP group had reduced the growth of corpus callosum body (difference = −0.02 ± 0.18, P = 0.034) compared with controls (difference = 0.03 ± 0.04). They subsequently had smaller body thickness of corpus callosum (0.10 ± 0.02, P = 0.015) at 37–40 gestational weeks than controls (0.14 ± 0.04). Conclusions: Serial monitoring corpus callosum and cerebellar vermis size in early life of very preterm babies may predict the motor or mentality neurological outcome at 5 years of age. Key Words: cerebellum, cerebral palsy, cranial ultrasound, mental retardation, preterm |
| format | Article |
| id | doaj-art-7effcd7250eb4cd6ac4e3533f98dec92 |
| institution | OA Journals |
| issn | 1875-9572 |
| language | English |
| publishDate | 2019-04-01 |
| publisher | Elsevier |
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| series | Pediatrics and Neonatology |
| spelling | doaj-art-7effcd7250eb4cd6ac4e3533f98dec922025-08-20T02:11:00ZengElsevierPediatrics and Neonatology1875-95722019-04-0160217818510.1016/j.pedneo.2018.05.012Corpus callosum and cerebellar vermis size in very preterm infants: Relationship to long-term neurodevelopmental outcomePo-Ming Wu0Hsin-I. Shih1Wen-Hao Yu2Li-Wen Chen3Lie-Chuan Wang4Chao-Ching Huang5Yi-Fang Tu6Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Emergency Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Pediatrics, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Pediatrics, Wan Fang Hospital, Taipei Medical University, Taipei, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Corresponding author. Department of Pediatrics, National Cheng Kung University Hospital, 138 Sheng-Li Road, North Dist., Tainan, 704, Taiwan. Fax: +886 6 275 3083..Background: The neonatal changes of corpus callosum or cerebellar volume in preterm infants have been shown to link with abnormal mentality and motor disability in early childhood. This study aims to predict the long-term neurological outcomes by measuring these changes on neonatal brain ultrasound in preterm infants. Methods: Our cohort consisted of infants aged below 32 weeks' gestation with very low birth body weights who completed neuro-assessments at 5 years of age. Corpus callosum or cerebellar vermis were measured at 28–30 weeks and at 37–40 weeks gestational age in premature infants with cerebral palsy (CP), mental retardation (MR) and normal control premature infants. Results: There are 12 patients in MR group, 12 in CP group and 27 patients as controls for final analysis. There was no significant difference in other factors between study groups except lower gestational age (P = 0.043) in CP group. Respiratory distress syndrome was more common in MR group (P = 0.037) and cystic periventricular leukomalacia was more common in CP group (P < 0.001) than controls. After adjusting for sex and birth body weight, the MR group had smaller cerebellar vermis area at 37–40 gestational weeks (P = 0.002) than controls. They also reduced the growth of corpus callosum area (difference = −0.12 ± 0.16, P = 0.029) and cerebellar vermis area (difference = 1.10 ± 0.44, P = 0.020) from 28 to 30 gestational weeks to 37–40 gestational weeks compared with controls (difference = 0.03 ± 0.15, 1.92 ± 0.70, respectively). In contrast, the CP group had reduced the growth of corpus callosum body (difference = −0.02 ± 0.18, P = 0.034) compared with controls (difference = 0.03 ± 0.04). They subsequently had smaller body thickness of corpus callosum (0.10 ± 0.02, P = 0.015) at 37–40 gestational weeks than controls (0.14 ± 0.04). Conclusions: Serial monitoring corpus callosum and cerebellar vermis size in early life of very preterm babies may predict the motor or mentality neurological outcome at 5 years of age. Key Words: cerebellum, cerebral palsy, cranial ultrasound, mental retardation, pretermhttp://www.sciencedirect.com/science/article/pii/S1875957217305466 |
| spellingShingle | Po-Ming Wu Hsin-I. Shih Wen-Hao Yu Li-Wen Chen Lie-Chuan Wang Chao-Ching Huang Yi-Fang Tu Corpus callosum and cerebellar vermis size in very preterm infants: Relationship to long-term neurodevelopmental outcome Pediatrics and Neonatology |
| title | Corpus callosum and cerebellar vermis size in very preterm infants: Relationship to long-term neurodevelopmental outcome |
| title_full | Corpus callosum and cerebellar vermis size in very preterm infants: Relationship to long-term neurodevelopmental outcome |
| title_fullStr | Corpus callosum and cerebellar vermis size in very preterm infants: Relationship to long-term neurodevelopmental outcome |
| title_full_unstemmed | Corpus callosum and cerebellar vermis size in very preterm infants: Relationship to long-term neurodevelopmental outcome |
| title_short | Corpus callosum and cerebellar vermis size in very preterm infants: Relationship to long-term neurodevelopmental outcome |
| title_sort | corpus callosum and cerebellar vermis size in very preterm infants relationship to long term neurodevelopmental outcome |
| url | http://www.sciencedirect.com/science/article/pii/S1875957217305466 |
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