The Relationship between Reproductive Hormones, MFG-E8, and Chlamydial Infection in Infertile Women
Background and Objective: Chlamydia trachomatis (CT) is a common sexually transmitted infection that is often symptomless and can cause long-term complications, including infertility. The objective of this study is to evaluate the relationship between reproductive hormones, MFG-E8 (Milk Fat Globule-...
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Babol University of Medical Sciences
2024-03-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
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| Online Access: | http://jbums.org/article-1-11453-en.pdf |
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| author | Sh Abd Hasan E Ali Hussein I Talib Hassan |
| author_facet | Sh Abd Hasan E Ali Hussein I Talib Hassan |
| author_sort | Sh Abd Hasan |
| collection | DOAJ |
| description | Background and Objective: Chlamydia trachomatis (CT) is a common sexually transmitted infection that is often symptomless and can cause long-term complications, including infertility. The objective of this study is to evaluate the relationship between reproductive hormones, MFG-E8 (Milk Fat Globule-Epidermal Growth Factor 8), and chlamydial infection in infertile women.
Methods: This cross-sectional study was conducted in Al-Salama Hospital between November 2021 and February 2023 on 90 participants, 60 infertile patients and 30 fertile individuals as a control group. The participants were divided into four groups based on their chlamydial infection status and serum levels of CT Ig-G, MFG-E8, AMH (Anti-Müllerian Hormone), LH (Luteinizing Hormone), and FSH (Follicle-Stimulating Hormone), Prolactin, and Testosterone were measured and compared using the ELISA technique.
Findings: A notable difference in Ig-G levels was observed based on chlamydia trachomatis infection status of female participants. The infertile group demonstrated significantly higher Ig-G levels, with a mean of 17.22±6.43 in the presence of positive Chlamydial infection, compared to the other groups (p<0.0001). In addition, the mean level of MFG-8 in the fertile group with chlamydia positive, at 215.65±26.07 ng/ml, was significantly higher compared to other groups (p<0.0001). No statistically significant difference was observed in MFG-E8 level between fertile and infertile patients.
Conclusion: The results of the study revealed a significant link between chlamydia trachomatis infection and infertility. The fertile women with Chlamydia-positive cases exhibited elevated levels of MFG-8, suggesting its potential involvement in reproductive health. These findings contribute to our understanding of the complex relationship between Chlamydia trachomatis infection, reproductive hormones, and infertility. |
| format | Article |
| id | doaj-art-7ef7b367543d4e119c8263d9b469cede |
| institution | DOAJ |
| issn | 1561-4107 2251-7170 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Babol University of Medical Sciences |
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| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| spelling | doaj-art-7ef7b367543d4e119c8263d9b469cede2025-08-20T02:39:23ZengBabol University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul1561-41072251-71702024-03-012600The Relationship between Reproductive Hormones, MFG-E8, and Chlamydial Infection in Infertile WomenSh Abd Hasan0E Ali Hussein1I Talib Hassan2 1.Department of Gynecology and Obstetrics, College of Medicine, Al-Iraqia University, Baghdad, Iraq. 1.Department of Gynecology and Obstetrics, College of Medicine, Al-Iraqia University, Baghdad, Iraq. 1.Department of Gynecology and Obstetrics, College of Medicine, Al-Iraqia University, Baghdad, Iraq. Background and Objective: Chlamydia trachomatis (CT) is a common sexually transmitted infection that is often symptomless and can cause long-term complications, including infertility. The objective of this study is to evaluate the relationship between reproductive hormones, MFG-E8 (Milk Fat Globule-Epidermal Growth Factor 8), and chlamydial infection in infertile women. Methods: This cross-sectional study was conducted in Al-Salama Hospital between November 2021 and February 2023 on 90 participants, 60 infertile patients and 30 fertile individuals as a control group. The participants were divided into four groups based on their chlamydial infection status and serum levels of CT Ig-G, MFG-E8, AMH (Anti-Müllerian Hormone), LH (Luteinizing Hormone), and FSH (Follicle-Stimulating Hormone), Prolactin, and Testosterone were measured and compared using the ELISA technique. Findings: A notable difference in Ig-G levels was observed based on chlamydia trachomatis infection status of female participants. The infertile group demonstrated significantly higher Ig-G levels, with a mean of 17.22±6.43 in the presence of positive Chlamydial infection, compared to the other groups (p<0.0001). In addition, the mean level of MFG-8 in the fertile group with chlamydia positive, at 215.65±26.07 ng/ml, was significantly higher compared to other groups (p<0.0001). No statistically significant difference was observed in MFG-E8 level between fertile and infertile patients. Conclusion: The results of the study revealed a significant link between chlamydia trachomatis infection and infertility. The fertile women with Chlamydia-positive cases exhibited elevated levels of MFG-8, suggesting its potential involvement in reproductive health. These findings contribute to our understanding of the complex relationship between Chlamydia trachomatis infection, reproductive hormones, and infertility.http://jbums.org/article-1-11453-en.pdfamhmfg-e8chlamydia trachomatisfertility hormoneinfertility. |
| spellingShingle | Sh Abd Hasan E Ali Hussein I Talib Hassan The Relationship between Reproductive Hormones, MFG-E8, and Chlamydial Infection in Infertile Women Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul amh mfg-e8 chlamydia trachomatis fertility hormone infertility. |
| title | The Relationship between Reproductive Hormones, MFG-E8, and Chlamydial Infection in Infertile Women |
| title_full | The Relationship between Reproductive Hormones, MFG-E8, and Chlamydial Infection in Infertile Women |
| title_fullStr | The Relationship between Reproductive Hormones, MFG-E8, and Chlamydial Infection in Infertile Women |
| title_full_unstemmed | The Relationship between Reproductive Hormones, MFG-E8, and Chlamydial Infection in Infertile Women |
| title_short | The Relationship between Reproductive Hormones, MFG-E8, and Chlamydial Infection in Infertile Women |
| title_sort | relationship between reproductive hormones mfg e8 and chlamydial infection in infertile women |
| topic | amh mfg-e8 chlamydia trachomatis fertility hormone infertility. |
| url | http://jbums.org/article-1-11453-en.pdf |
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