Huge splenomegaly, a rare presentation of multicentric Castleman’s disease in an HIV-infected patient: a case report and literature review
Introduction Castleman’s disease (CD) is characterized by non-neoplastic lymph node hyperplasia, and may be localized in a single lymph node (unicentric) or occurs systemically (multicentric). Nowadays, multicentric CD is most commonly observed in individuals infected with human immunodeficiency vi...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2024-10-01
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| Series: | HIV & AIDS Review. International Journal of HIV-Related Problems |
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| Online Access: | https://hivaids.termedia.pl/Huge-splenomegaly-a-rare-presentation-nof-multicentric-Castleman-s-disease-nin-an,151536,0,2.html |
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| _version_ | 1832584799030607872 |
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| author | Malihe Hasannezad Abdolkarim Haji Ghadery Sara Ghaderkhani Armin Vazirian Fereshteh Ameli Farid Azmoudeh-Ardalan Mohammad Reza Rafiian Naini Ladan Abbasian |
| author_facet | Malihe Hasannezad Abdolkarim Haji Ghadery Sara Ghaderkhani Armin Vazirian Fereshteh Ameli Farid Azmoudeh-Ardalan Mohammad Reza Rafiian Naini Ladan Abbasian |
| author_sort | Malihe Hasannezad |
| collection | DOAJ |
| description | Introduction
Castleman’s disease (CD) is characterized by non-neoplastic lymph node hyperplasia, and may be localized in a single lymph node (unicentric) or occurs systemically (multicentric). Nowadays, multicentric CD is most commonly observed in individuals infected with human immunodeficiency virus (HIV) type 1, in association with Kaposi’s sarcoma. Histopathologic and immunohistochemical evaluation of excised lymph node as well as imaging modalities, such as computed tomography (CT) and magnetic resonance imaging, are required for the diagnosis of CD.
Case description
We present a case of 46-year-old HIV-infected woman with fever, weakness, weight loss, and splenomegaly in the past 18 months. On physical examination, pale conjunctiva, jaundice, multiple cervical, inguinal, and axillary lymphadenopathies as well as hepatosplenomegaly were detected. Chest CT scan showed alveolar opacity in the lower lobe of the right lung and multiple lymph nodes in the mediastinum and bilateral perivascular, cervical, and axillary areas. Abdominopelvic CT scan showed huge splenomegaly, hepatomegaly, and multiple bilateral para-aortic, celiac, and inguinal lymphadenopathies, which were further confirmed as CD in pathological examination.
Conclusions
Huge splenomegaly is a rare manifestation in CD. Among the more prevalent differential diagnoses, CD in patients with HIV and huge splenomegaly was emphasized as important differential diagnosis.
Conclusions |
| format | Article |
| id | doaj-art-7ef74c85c34443988b69a6fc8229780e |
| institution | Kabale University |
| issn | 1730-1270 1732-2707 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | HIV & AIDS Review. International Journal of HIV-Related Problems |
| spelling | doaj-art-7ef74c85c34443988b69a6fc8229780e2025-01-27T11:05:57ZengTermedia Publishing HouseHIV & AIDS Review. International Journal of HIV-Related Problems1730-12701732-27072024-10-0123326827210.5114/hivar/151536151536Huge splenomegaly, a rare presentation of multicentric Castleman’s disease in an HIV-infected patient: a case report and literature reviewMalihe Hasannezad0Abdolkarim Haji Ghadery1https://orcid.org/0000-0002-9215-8037Sara Ghaderkhani2Armin Vazirian3Fereshteh Ameli4Farid Azmoudeh-Ardalan5Mohammad Reza Rafiian Naini6Ladan Abbasian7Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Department of Infectious Diseases, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Radiology, Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, IranDepartment of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranDepartment of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranDepartment of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranDepartment of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranDepartment of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranIranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Department of Infectious Diseases, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, IranIntroduction Castleman’s disease (CD) is characterized by non-neoplastic lymph node hyperplasia, and may be localized in a single lymph node (unicentric) or occurs systemically (multicentric). Nowadays, multicentric CD is most commonly observed in individuals infected with human immunodeficiency virus (HIV) type 1, in association with Kaposi’s sarcoma. Histopathologic and immunohistochemical evaluation of excised lymph node as well as imaging modalities, such as computed tomography (CT) and magnetic resonance imaging, are required for the diagnosis of CD. Case description We present a case of 46-year-old HIV-infected woman with fever, weakness, weight loss, and splenomegaly in the past 18 months. On physical examination, pale conjunctiva, jaundice, multiple cervical, inguinal, and axillary lymphadenopathies as well as hepatosplenomegaly were detected. Chest CT scan showed alveolar opacity in the lower lobe of the right lung and multiple lymph nodes in the mediastinum and bilateral perivascular, cervical, and axillary areas. Abdominopelvic CT scan showed huge splenomegaly, hepatomegaly, and multiple bilateral para-aortic, celiac, and inguinal lymphadenopathies, which were further confirmed as CD in pathological examination. Conclusions Huge splenomegaly is a rare manifestation in CD. Among the more prevalent differential diagnoses, CD in patients with HIV and huge splenomegaly was emphasized as important differential diagnosis. Conclusionshttps://hivaids.termedia.pl/Huge-splenomegaly-a-rare-presentation-nof-multicentric-Castleman-s-disease-nin-an,151536,0,2.htmlsplenomegalymulticentric castleman’s diseasepatients with hivcase report |
| spellingShingle | Malihe Hasannezad Abdolkarim Haji Ghadery Sara Ghaderkhani Armin Vazirian Fereshteh Ameli Farid Azmoudeh-Ardalan Mohammad Reza Rafiian Naini Ladan Abbasian Huge splenomegaly, a rare presentation of multicentric Castleman’s disease in an HIV-infected patient: a case report and literature review HIV & AIDS Review. International Journal of HIV-Related Problems splenomegaly multicentric castleman’s disease patients with hiv case report |
| title | Huge splenomegaly, a rare presentation
of multicentric Castleman’s disease
in an HIV-infected patient: a case report
and literature review |
| title_full | Huge splenomegaly, a rare presentation
of multicentric Castleman’s disease
in an HIV-infected patient: a case report
and literature review |
| title_fullStr | Huge splenomegaly, a rare presentation
of multicentric Castleman’s disease
in an HIV-infected patient: a case report
and literature review |
| title_full_unstemmed | Huge splenomegaly, a rare presentation
of multicentric Castleman’s disease
in an HIV-infected patient: a case report
and literature review |
| title_short | Huge splenomegaly, a rare presentation
of multicentric Castleman’s disease
in an HIV-infected patient: a case report
and literature review |
| title_sort | huge splenomegaly a rare presentation of multicentric castleman s disease in an hiv infected patient a case report and literature review |
| topic | splenomegaly multicentric castleman’s disease patients with hiv case report |
| url | https://hivaids.termedia.pl/Huge-splenomegaly-a-rare-presentation-nof-multicentric-Castleman-s-disease-nin-an,151536,0,2.html |
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