The Effects of Music Intervention on Functional Connectivity Strength of the Brain in Schizophrenia
Schizophrenia is often associated with behavior abnormality in the cognitive and affective domain. Music intervention is used as a complementary treatment for improving symptoms in patients with schizophrenia. However, the neurophysiological correlates of these remissions remain poorly understood. H...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/2821832 |
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| author | Mi Yang Hui He Mingjun Duan Xi Chen Xin Chang Yongxiu Lai Jianfu Li Tiejun Liu Cheng Luo Dezhong Yao |
| author_facet | Mi Yang Hui He Mingjun Duan Xi Chen Xin Chang Yongxiu Lai Jianfu Li Tiejun Liu Cheng Luo Dezhong Yao |
| author_sort | Mi Yang |
| collection | DOAJ |
| description | Schizophrenia is often associated with behavior abnormality in the cognitive and affective domain. Music intervention is used as a complementary treatment for improving symptoms in patients with schizophrenia. However, the neurophysiological correlates of these remissions remain poorly understood. Here, we investigated the effects of music intervention in neural circuits through functional magnetic resonance imaging (fMRI) study in schizophrenic subjects. Under the standard care, patients were randomly assigned to music and non-music interventions (MTSZ, UMTSZ) for 1 month. Resting-state fMRI were acquired over three time points (baseline, 1 month, and 6 months later) in patients and analyzed using functional connectivity strength (FCS) and seed-based functional connection (FC) approaches. At baseline, compared with healthy controls, decreased FCS in the right middle temporal gyrus (MTG) was observed in patients. However, after music intervention, the functional circuitry of the right MTG, which was related with the function of emotion and sensorimotor, was improved in MTSZ. Furthermore, the FC increments were significantly correlated with the improvement of symptoms, while vanishing 6 months later. Together, these findings provided evidence that music intervention might positively modulate the functional connectivity of MTG in patients with schizophrenia; such changes might be associated with the observed therapeutic effects of music intervention on neurocognitive function. This trial is registered with ChiCTR-OPC-14005339. |
| format | Article |
| id | doaj-art-7ef6c6f92a644fdba96da820a8fcda38 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-7ef6c6f92a644fdba96da820a8fcda382025-08-20T03:35:40ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/28218322821832The Effects of Music Intervention on Functional Connectivity Strength of the Brain in SchizophreniaMi Yang0Hui He1Mingjun Duan2Xi Chen3Xin Chang4Yongxiu Lai5Jianfu Li6Tiejun Liu7Cheng Luo8Dezhong Yao9The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaSchizophrenia is often associated with behavior abnormality in the cognitive and affective domain. Music intervention is used as a complementary treatment for improving symptoms in patients with schizophrenia. However, the neurophysiological correlates of these remissions remain poorly understood. Here, we investigated the effects of music intervention in neural circuits through functional magnetic resonance imaging (fMRI) study in schizophrenic subjects. Under the standard care, patients were randomly assigned to music and non-music interventions (MTSZ, UMTSZ) for 1 month. Resting-state fMRI were acquired over three time points (baseline, 1 month, and 6 months later) in patients and analyzed using functional connectivity strength (FCS) and seed-based functional connection (FC) approaches. At baseline, compared with healthy controls, decreased FCS in the right middle temporal gyrus (MTG) was observed in patients. However, after music intervention, the functional circuitry of the right MTG, which was related with the function of emotion and sensorimotor, was improved in MTSZ. Furthermore, the FC increments were significantly correlated with the improvement of symptoms, while vanishing 6 months later. Together, these findings provided evidence that music intervention might positively modulate the functional connectivity of MTG in patients with schizophrenia; such changes might be associated with the observed therapeutic effects of music intervention on neurocognitive function. This trial is registered with ChiCTR-OPC-14005339.http://dx.doi.org/10.1155/2018/2821832 |
| spellingShingle | Mi Yang Hui He Mingjun Duan Xi Chen Xin Chang Yongxiu Lai Jianfu Li Tiejun Liu Cheng Luo Dezhong Yao The Effects of Music Intervention on Functional Connectivity Strength of the Brain in Schizophrenia Neural Plasticity |
| title | The Effects of Music Intervention on Functional Connectivity Strength of the Brain in Schizophrenia |
| title_full | The Effects of Music Intervention on Functional Connectivity Strength of the Brain in Schizophrenia |
| title_fullStr | The Effects of Music Intervention on Functional Connectivity Strength of the Brain in Schizophrenia |
| title_full_unstemmed | The Effects of Music Intervention on Functional Connectivity Strength of the Brain in Schizophrenia |
| title_short | The Effects of Music Intervention on Functional Connectivity Strength of the Brain in Schizophrenia |
| title_sort | effects of music intervention on functional connectivity strength of the brain in schizophrenia |
| url | http://dx.doi.org/10.1155/2018/2821832 |
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