Cathepsin C correlates with M2 macrophage infiltration and regulates the tumor growth and metastasis in non-small cell lung cancer

Cathepsin C correlates with M2 macrophage infiltration and regulates the tumor growth and metastasis in non-small cell lung cancer

Abstract Cathepsin C (CTSC) is a cysteine protease in lysosomes that controls immunological responses. Upregulation CTSC expression was reportedly related with tumor progression and metastasis. The roles and mechanisms of CTSC in non-small cell lung cancer (NSCLC) are still unclear. Through systemat...

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Bibliographic Details
Main Authors: Xiaoxia Tong, Ting Zhu, Li Ma, Xiaohu Yang, Chenghui Li, Yibing Liu, Xuan Qin, Yanguang Ding, Hongwei Xia, Yonglei Liu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Cancer
Subjects:
Non-small cell lung cancer
CTSC
Cancer cell proliferation
Metastasis
M2 macrophage
Online Access:https://doi.org/10.1186/s12885-025-14341-3
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