Effectiveness of finerenone in Chinese patients with type 2 diabetes mellitus and chronic kidney disease with microalbuminuria: A retrospective real‐world study
ABSTRACT Aim No studies have specifically examined the effects of finerenone in treating type 2 diabetes patients with chronic kidney disease (CKD) and microalbuminuria. This study aimed to evaluate the effectiveness of finerenone in this group of patients. Methods This retrospective real‐world stud...
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Wiley
2025-06-01
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| Series: | Journal of Diabetes Investigation |
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| Online Access: | https://doi.org/10.1111/jdi.70023 |
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| author | Yiming Wu Ying Gao Xiaohui Guo Junqing Zhang Ang Li |
| author_facet | Yiming Wu Ying Gao Xiaohui Guo Junqing Zhang Ang Li |
| author_sort | Yiming Wu |
| collection | DOAJ |
| description | ABSTRACT Aim No studies have specifically examined the effects of finerenone in treating type 2 diabetes patients with chronic kidney disease (CKD) and microalbuminuria. This study aimed to evaluate the effectiveness of finerenone in this group of patients. Methods This retrospective real‐world study (ChiCTR2400087169) included type 2 diabetes outpatients with CKD from the Peking University First Hospital between March 2023 and March 2024. All patients in this study had a urinary albumin‐to‐creatinine ratio (UACR) of 30–299 mg/g. The effects of finerenone were assessed by comparing UACR, HbA1c, creatinine, serum potassium, eGFR, and blood pressure at baseline and after treatment. Results Sixty‐four patients (39 males and 25 females), with a median age of 65.75 years and a median duration of T2DM of 15.21 years, were included. The baseline median UACR was 100.50 mg/g, significantly decreased to 61.27 mg/g (P < 0.001) at 3 months and 62.49 mg/g (P < 0.001) at 6 months after treatment. None of the other parameters differed significantly. Finerenone alone or in combination with ABS inhibitors, SGLT2 inhibitors, or GLP‐1 agonists did not result in significant differences in UACR reduction. Patients with a >30% UACR decrease had significantly higher baseline systolic blood pressure (SBP) than those with a ≤30% decrease (P < 0.05). Furthermore, baseline SBP significantly decreased after 6 months of treatment in patients with a >30% UACR reduction (P < 0.05). Conclusions Finerenone is effective in treating type 2 diabetes with CKD and microalbuminuria. Improved SBP control leads to a greater UACR reduction. |
| format | Article |
| id | doaj-art-7ef29d2f1ff24d0f822959e078d2f90e |
| institution | DOAJ |
| issn | 2040-1116 2040-1124 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj-art-7ef29d2f1ff24d0f822959e078d2f90e2025-08-20T03:07:39ZengWileyJournal of Diabetes Investigation2040-11162040-11242025-06-011661028103310.1111/jdi.70023Effectiveness of finerenone in Chinese patients with type 2 diabetes mellitus and chronic kidney disease with microalbuminuria: A retrospective real‐world studyYiming Wu0Ying Gao1Xiaohui Guo2Junqing Zhang3Ang Li4Department of Endocrinology Peking University First Hospital Beijing ChinaDepartment of Endocrinology Peking University First Hospital Beijing ChinaDepartment of Endocrinology Peking University First Hospital Beijing ChinaDepartment of Endocrinology Peking University First Hospital Beijing ChinaDepartment of Endocrinology Peking University First Hospital Beijing ChinaABSTRACT Aim No studies have specifically examined the effects of finerenone in treating type 2 diabetes patients with chronic kidney disease (CKD) and microalbuminuria. This study aimed to evaluate the effectiveness of finerenone in this group of patients. Methods This retrospective real‐world study (ChiCTR2400087169) included type 2 diabetes outpatients with CKD from the Peking University First Hospital between March 2023 and March 2024. All patients in this study had a urinary albumin‐to‐creatinine ratio (UACR) of 30–299 mg/g. The effects of finerenone were assessed by comparing UACR, HbA1c, creatinine, serum potassium, eGFR, and blood pressure at baseline and after treatment. Results Sixty‐four patients (39 males and 25 females), with a median age of 65.75 years and a median duration of T2DM of 15.21 years, were included. The baseline median UACR was 100.50 mg/g, significantly decreased to 61.27 mg/g (P < 0.001) at 3 months and 62.49 mg/g (P < 0.001) at 6 months after treatment. None of the other parameters differed significantly. Finerenone alone or in combination with ABS inhibitors, SGLT2 inhibitors, or GLP‐1 agonists did not result in significant differences in UACR reduction. Patients with a >30% UACR decrease had significantly higher baseline systolic blood pressure (SBP) than those with a ≤30% decrease (P < 0.05). Furthermore, baseline SBP significantly decreased after 6 months of treatment in patients with a >30% UACR reduction (P < 0.05). Conclusions Finerenone is effective in treating type 2 diabetes with CKD and microalbuminuria. Improved SBP control leads to a greater UACR reduction.https://doi.org/10.1111/jdi.70023Diabetes mellitus, type 2FinerenoneMicroalbuminuria |
| spellingShingle | Yiming Wu Ying Gao Xiaohui Guo Junqing Zhang Ang Li Effectiveness of finerenone in Chinese patients with type 2 diabetes mellitus and chronic kidney disease with microalbuminuria: A retrospective real‐world study Journal of Diabetes Investigation Diabetes mellitus, type 2 Finerenone Microalbuminuria |
| title | Effectiveness of finerenone in Chinese patients with type 2 diabetes mellitus and chronic kidney disease with microalbuminuria: A retrospective real‐world study |
| title_full | Effectiveness of finerenone in Chinese patients with type 2 diabetes mellitus and chronic kidney disease with microalbuminuria: A retrospective real‐world study |
| title_fullStr | Effectiveness of finerenone in Chinese patients with type 2 diabetes mellitus and chronic kidney disease with microalbuminuria: A retrospective real‐world study |
| title_full_unstemmed | Effectiveness of finerenone in Chinese patients with type 2 diabetes mellitus and chronic kidney disease with microalbuminuria: A retrospective real‐world study |
| title_short | Effectiveness of finerenone in Chinese patients with type 2 diabetes mellitus and chronic kidney disease with microalbuminuria: A retrospective real‐world study |
| title_sort | effectiveness of finerenone in chinese patients with type 2 diabetes mellitus and chronic kidney disease with microalbuminuria a retrospective real world study |
| topic | Diabetes mellitus, type 2 Finerenone Microalbuminuria |
| url | https://doi.org/10.1111/jdi.70023 |
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