Effect of Hypertensive Disorders of Pregnancy (HDP) on maternal and perinatal birth outcomes in Eastern Ethiopia: a prospective cohort study
Abstract Background Globally, hypertensive disorders of pregnancy are the major causes of maternal and perinatal morbidity and mortality. In low and middle-income countries, including Ethiopia, studies on the effect of hypertensive disorders of pregnancy on maternal and perinatal birth outcomes are...
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BMC
2025-05-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-025-07707-9 |
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| author | Ebisa Zerihun Firaol Girma Nimona Amena Wubet Tazeb Wondie Belete Feyera Olkaba Lemma Mideksa Egu Solomon Seyife Alemu Gemechu Gelan Bekele Belay Tafa Regassa Meseret Robi Tura Fekadu Abera Kebede |
| author_facet | Ebisa Zerihun Firaol Girma Nimona Amena Wubet Tazeb Wondie Belete Feyera Olkaba Lemma Mideksa Egu Solomon Seyife Alemu Gemechu Gelan Bekele Belay Tafa Regassa Meseret Robi Tura Fekadu Abera Kebede |
| author_sort | Ebisa Zerihun |
| collection | DOAJ |
| description | Abstract Background Globally, hypertensive disorders of pregnancy are the major causes of maternal and perinatal morbidity and mortality. In low and middle-income countries, including Ethiopia, studies on the effect of hypertensive disorders of pregnancy on maternal and perinatal birth outcomes are limited. Objectives The aim of this study was to examine the effect of hypertensive disorders of pregnancy on maternal and perinatal birth outcomes in Eastern Ethiopia. Methods We employed a prospective cohort study design involving 374 pregnant women, equally divided into hypertensive ((n = 187) and normotensive (n = 187). Data were collected face to face using an interviewer-administered questionnaire as well as by reviewing the medical records of the mothers. Data analysis was done in STATA Version 17. Binary logistic regression was run to produce risk ratios (relative risk) and 95% confidence intervals along with their p-values were calculated in the bivariate and multivariable analyses. Significance was declared at a P-value of less than 0.05. Results Compared with normotensive, women with hypertensive disorder had significantly increased risk of developing preterm birth (cRR = 1.8; 95% CI, 1.5, 2.2), stillbirth (cRR = 1.6; 95% CI, 1.3, 2.02), low birth weight (cRR = 1.9; 95% CI, 1.6, 2.3), and early neonatal death (cRR = 1.7; 95% CI, 1.3, 2.3). Women with hypertensive disorders had 2.6 times (aRR = 2.6, 95% CI; 1.2, 5.7) higher risk of perinatal death, and 1.7 (aRR = 1.7; 95%CI, 1.02, 2.90) times higher risk of cesarean section delivery compared with the normotensive women controlling the other variables. Conclusion Significant risk of cesarean section delivery, perinatal death, stillbirth, low birth weight delivery, and early neonatal death were reported among women with hypertensive disorders of pregnancy. To minimize the burden of the problem, much has to be done by health care professionals and stakeholders focusing on the identification and proper management of mothers with hypertensive disorders. |
| format | Article |
| id | doaj-art-7eed32c0ff7d4ebabb73085e997cd27d |
| institution | DOAJ |
| issn | 1471-2393 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
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| series | BMC Pregnancy and Childbirth |
| spelling | doaj-art-7eed32c0ff7d4ebabb73085e997cd27d2025-08-20T03:16:31ZengBMCBMC Pregnancy and Childbirth1471-23932025-05-0125111210.1186/s12884-025-07707-9Effect of Hypertensive Disorders of Pregnancy (HDP) on maternal and perinatal birth outcomes in Eastern Ethiopia: a prospective cohort studyEbisa Zerihun0Firaol Girma1Nimona Amena2Wubet Tazeb Wondie3Belete Feyera Olkaba4Lemma Mideksa Egu5Solomon Seyife Alemu6Gemechu Gelan Bekele7Belay Tafa Regassa8Meseret Robi Tura9Fekadu Abera Kebede10Department of Nursing, College of Health Sciences, Oda Bultum UniversityDepartment of Nursing, College of Health Sciences, Oda Bultum UniversityDepartment of Nursing, College of Health Sciences and Referral Hospital, Ambo UniversityDepartment of Pediatrics and Child Health Nursing, College of Health Sciences and Referral Hospital, Ambo UniversityDepartment of Public Health, College of Health Sciences and Referral Hospital, Ambo UniversityDepartment of Nursing, College of Health Sciences and Referral Hospital, Ambo UniversityDepartment of Midwifery, College of Health Science Shashemene Campus, Madda Walabu UniversityDepartment of Midwifery, College of Health Science Shashemene Campus, Madda Walabu UniversityDepartment of Medical Laboratory Sciences, College of Health Sciences and Referral Hospital, Ambo UniversityDepartment of Nursing, College of Health Sciences and Referral Hospital, Ambo UniversityDepartment of Nursing, College of Health Sciences, Oda Bultum UniversityAbstract Background Globally, hypertensive disorders of pregnancy are the major causes of maternal and perinatal morbidity and mortality. In low and middle-income countries, including Ethiopia, studies on the effect of hypertensive disorders of pregnancy on maternal and perinatal birth outcomes are limited. Objectives The aim of this study was to examine the effect of hypertensive disorders of pregnancy on maternal and perinatal birth outcomes in Eastern Ethiopia. Methods We employed a prospective cohort study design involving 374 pregnant women, equally divided into hypertensive ((n = 187) and normotensive (n = 187). Data were collected face to face using an interviewer-administered questionnaire as well as by reviewing the medical records of the mothers. Data analysis was done in STATA Version 17. Binary logistic regression was run to produce risk ratios (relative risk) and 95% confidence intervals along with their p-values were calculated in the bivariate and multivariable analyses. Significance was declared at a P-value of less than 0.05. Results Compared with normotensive, women with hypertensive disorder had significantly increased risk of developing preterm birth (cRR = 1.8; 95% CI, 1.5, 2.2), stillbirth (cRR = 1.6; 95% CI, 1.3, 2.02), low birth weight (cRR = 1.9; 95% CI, 1.6, 2.3), and early neonatal death (cRR = 1.7; 95% CI, 1.3, 2.3). Women with hypertensive disorders had 2.6 times (aRR = 2.6, 95% CI; 1.2, 5.7) higher risk of perinatal death, and 1.7 (aRR = 1.7; 95%CI, 1.02, 2.90) times higher risk of cesarean section delivery compared with the normotensive women controlling the other variables. Conclusion Significant risk of cesarean section delivery, perinatal death, stillbirth, low birth weight delivery, and early neonatal death were reported among women with hypertensive disorders of pregnancy. To minimize the burden of the problem, much has to be done by health care professionals and stakeholders focusing on the identification and proper management of mothers with hypertensive disorders.https://doi.org/10.1186/s12884-025-07707-9PregnancyHypertensive disordersPerinatal outcomeWest HarargheMaternal outcomeEthiopia |
| spellingShingle | Ebisa Zerihun Firaol Girma Nimona Amena Wubet Tazeb Wondie Belete Feyera Olkaba Lemma Mideksa Egu Solomon Seyife Alemu Gemechu Gelan Bekele Belay Tafa Regassa Meseret Robi Tura Fekadu Abera Kebede Effect of Hypertensive Disorders of Pregnancy (HDP) on maternal and perinatal birth outcomes in Eastern Ethiopia: a prospective cohort study BMC Pregnancy and Childbirth Pregnancy Hypertensive disorders Perinatal outcome West Hararghe Maternal outcome Ethiopia |
| title | Effect of Hypertensive Disorders of Pregnancy (HDP) on maternal and perinatal birth outcomes in Eastern Ethiopia: a prospective cohort study |
| title_full | Effect of Hypertensive Disorders of Pregnancy (HDP) on maternal and perinatal birth outcomes in Eastern Ethiopia: a prospective cohort study |
| title_fullStr | Effect of Hypertensive Disorders of Pregnancy (HDP) on maternal and perinatal birth outcomes in Eastern Ethiopia: a prospective cohort study |
| title_full_unstemmed | Effect of Hypertensive Disorders of Pregnancy (HDP) on maternal and perinatal birth outcomes in Eastern Ethiopia: a prospective cohort study |
| title_short | Effect of Hypertensive Disorders of Pregnancy (HDP) on maternal and perinatal birth outcomes in Eastern Ethiopia: a prospective cohort study |
| title_sort | effect of hypertensive disorders of pregnancy hdp on maternal and perinatal birth outcomes in eastern ethiopia a prospective cohort study |
| topic | Pregnancy Hypertensive disorders Perinatal outcome West Hararghe Maternal outcome Ethiopia |
| url | https://doi.org/10.1186/s12884-025-07707-9 |
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