Age-related behavioural abnormalities in C57BL/6.KOR–Apoe shl mice
Spontaneously hyperlipidaemic (Apoeshl) mice were discovered in 1999 as mice lacking apolipoprotein E (ApoE) owing to a mutation in the Apoe gene. However, age-related behavioural changes in commercially available Apoeshl mice have not yet been clarified. The behavioural abnormalities of ApoE-defici...
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| Language: | English |
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De Gruyter
2025-02-01
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| Series: | Translational Neuroscience |
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| Online Access: | https://doi.org/10.1515/tnsci-2022-0363 |
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| author | Ueno Hiroshi Takahashi Yu Mori Sachiko Kitano Eriko Murakami Shinji Wani Kenta Miyazaki Tetsuji Matsumoto Yosuke Okamoto Motoi Ishihara Takeshi |
| author_facet | Ueno Hiroshi Takahashi Yu Mori Sachiko Kitano Eriko Murakami Shinji Wani Kenta Miyazaki Tetsuji Matsumoto Yosuke Okamoto Motoi Ishihara Takeshi |
| author_sort | Ueno Hiroshi |
| collection | DOAJ |
| description | Spontaneously hyperlipidaemic (Apoeshl) mice were discovered in 1999 as mice lacking apolipoprotein E (ApoE) owing to a mutation in the Apoe gene. However, age-related behavioural changes in commercially available Apoeshl mice have not yet been clarified. The behavioural abnormalities of ApoE-deficient mice, which are genetically modified mice artificially deficient in ApoE, have been investigated in detail, and it has been reported that they can serve as a model of Alzheimer’s disease (AD). To understand whether Apoeshl mice can also serve as a murine model of AD, it is necessary to investigate age-related behavioural abnormalities in Apoeshl mice. In this study, we conducted a series of behavioural experiments on 7- and 11-month-old Apoeshl mice to investigate the behavioural abnormalities associated with ageing in Apoeshl mice. In this study, 7-month-old Apoeshl mice showed decreased body weight and grip strength compared to age-matched wild-type mice. In the open field test, 7-month-old Apoeshl mice showed increased anxiety-like behaviour compared to wild-type mice, whereas 11-month-old Apoeshl mice showed decreased anxiety-like behaviour. Moreover, Apoeshl mice aged 7 and 11 months had increased serum cholesterol levels. These results indicate that the behaviour of Apoeshl mice changes with age. However, 11-month-old Apoeshl mice did not show a decline in cognitive function or memory ability similar to murine models of AD. Our findings indicate that Apoeshl mice can be used to investigate the function of ApoE in the central nervous system. |
| format | Article |
| id | doaj-art-7eebf660d3d64f6fb61092c433d804c4 |
| institution | OA Journals |
| issn | 2081-6936 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Translational Neuroscience |
| spelling | doaj-art-7eebf660d3d64f6fb61092c433d804c42025-08-20T02:00:51ZengDe GruyterTranslational Neuroscience2081-69362025-02-01161143526010.1515/tnsci-2022-0363Age-related behavioural abnormalities in C57BL/6.KOR–Apoe shl miceUeno Hiroshi0Takahashi Yu1Mori Sachiko2Kitano Eriko3Murakami Shinji4Wani Kenta5Miyazaki Tetsuji6Matsumoto Yosuke7Okamoto Motoi8Ishihara Takeshi9Department of Medical Technology, Kawasaki University of Medical Welfare, Okayama, 701-0193, JapanDepartment of Psychiatry, Kawasaki Medical School, Kurashiki, 701-0192, JapanDepartment of Psychiatry, Kawasaki Medical School, Kurashiki, 701-0192, JapanDepartment of Psychiatry, Kawasaki Medical School, Kurashiki, 701-0192, JapanDepartment of Psychiatry, Kawasaki Medical School, Kurashiki, 701-0192, JapanDepartment of Psychiatry, Kawasaki Medical School, Kurashiki, 701-0192, JapanDepartment of Psychiatry, Kawasaki Medical School, Kurashiki, 701-0192, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, 700-8558, JapanDepartment of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama, 700-8558, JapanDepartment of Psychiatry, Kawasaki Medical School, Kurashiki, 701-0192, JapanSpontaneously hyperlipidaemic (Apoeshl) mice were discovered in 1999 as mice lacking apolipoprotein E (ApoE) owing to a mutation in the Apoe gene. However, age-related behavioural changes in commercially available Apoeshl mice have not yet been clarified. The behavioural abnormalities of ApoE-deficient mice, which are genetically modified mice artificially deficient in ApoE, have been investigated in detail, and it has been reported that they can serve as a model of Alzheimer’s disease (AD). To understand whether Apoeshl mice can also serve as a murine model of AD, it is necessary to investigate age-related behavioural abnormalities in Apoeshl mice. In this study, we conducted a series of behavioural experiments on 7- and 11-month-old Apoeshl mice to investigate the behavioural abnormalities associated with ageing in Apoeshl mice. In this study, 7-month-old Apoeshl mice showed decreased body weight and grip strength compared to age-matched wild-type mice. In the open field test, 7-month-old Apoeshl mice showed increased anxiety-like behaviour compared to wild-type mice, whereas 11-month-old Apoeshl mice showed decreased anxiety-like behaviour. Moreover, Apoeshl mice aged 7 and 11 months had increased serum cholesterol levels. These results indicate that the behaviour of Apoeshl mice changes with age. However, 11-month-old Apoeshl mice did not show a decline in cognitive function or memory ability similar to murine models of AD. Our findings indicate that Apoeshl mice can be used to investigate the function of ApoE in the central nervous system.https://doi.org/10.1515/tnsci-2022-0363ageapolipoproteinbehavioural testcentral nervous systemmouse |
| spellingShingle | Ueno Hiroshi Takahashi Yu Mori Sachiko Kitano Eriko Murakami Shinji Wani Kenta Miyazaki Tetsuji Matsumoto Yosuke Okamoto Motoi Ishihara Takeshi Age-related behavioural abnormalities in C57BL/6.KOR–Apoe shl mice Translational Neuroscience age apolipoprotein behavioural test central nervous system mouse |
| title | Age-related behavioural abnormalities in C57BL/6.KOR–Apoe
shl mice |
| title_full | Age-related behavioural abnormalities in C57BL/6.KOR–Apoe
shl mice |
| title_fullStr | Age-related behavioural abnormalities in C57BL/6.KOR–Apoe
shl mice |
| title_full_unstemmed | Age-related behavioural abnormalities in C57BL/6.KOR–Apoe
shl mice |
| title_short | Age-related behavioural abnormalities in C57BL/6.KOR–Apoe
shl mice |
| title_sort | age related behavioural abnormalities in c57bl 6 kor apoe shl mice |
| topic | age apolipoprotein behavioural test central nervous system mouse |
| url | https://doi.org/10.1515/tnsci-2022-0363 |
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