The increase in autophagy induced by naringin alleviates Schwann cell apoptosis mediated by the AMPK/mTOR signalling pathway

The increase in autophagy induced by naringin alleviates Schwann cell apoptosis mediated by the AMPK/mTOR signalling pathway

Abstract Background Peripheral nerve injury (PNI) is currently an intractable disease for clinical therapeutics. Schwann cells (SCs) play pivotal roles in peripheral nerve regeneration. Naringin, a natural flavonoid, has potent beneficial effects on peripheral neuropathy. Researchers have rarely rep...

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Bibliographic Details
Main Authors: Jianwei Lv, Duo Shan, Haobo Jia, Zengliang Wang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Schwann cell
Naringin
Autophagy
Apoptosis
AMPK
Peripheral nerve regeneration
Online Access:https://doi.org/10.1186/s13018-025-05969-9
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