The Predictive Significance of Various Prognostic Scoring Systems on the Efficacy of Immunotherapy in Non‐Small Cell Lung Cancer Patients: A Retrospective Study
ABSTRACT Background and Aims To evaluate the efficacy and prognostic value of various immunoprognostic scoring systems—Lung Immune Prognostic Index (LIPI), modified Glasgow Prognostic Score (mGPS), and Gustave Roussy Immune Score (GRIm)—in non‐small cell lung cancer (NSCLC) patients treated with imm...
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Wiley
2025-04-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.70713 |
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| author | Jianying Liu Jinzhan Chen Congyi Xie Haiyan Chen Shuwen Yang Hongni Jiang Yijiao Xu |
| author_facet | Jianying Liu Jinzhan Chen Congyi Xie Haiyan Chen Shuwen Yang Hongni Jiang Yijiao Xu |
| author_sort | Jianying Liu |
| collection | DOAJ |
| description | ABSTRACT Background and Aims To evaluate the efficacy and prognostic value of various immunoprognostic scoring systems—Lung Immune Prognostic Index (LIPI), modified Glasgow Prognostic Score (mGPS), and Gustave Roussy Immune Score (GRIm)—in non‐small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs). Methods We conducted a retrospective analysis of clinical data from 219 NSCLC patients treated with ICIs at Zhongshan Hospital (Xiamen), Fudan University from June 1, 2019 to January 31, 2024. The therapeutic efficacy and predictive capabilities of the scoring systems were assessed using Kaplan–Meier curves, Cox proportional hazards models, time‐dependent ROC curves, and random survival forest models. Results The median follow‐up was 29 months (IQR: 25.96–32.04), resulting in 93 observed deaths. Both LIPI and GRIm scores correlated with declining overall survival (OS) and progression‐free survival (PFS) as risk levels increased. LIPI demonstrated superior predictive performance at 12, 24, and 36 months (AUC: 0.70, 0.62, 0.61, respectively). Multivariate analysis identified immune‐related adverse events (irAEs) and lactate dehydrogenase (LDH) levels as independent prognostic factors for OS. Conclusion LIPI serves as an effective prognostic tool for NSCLC patients receiving immunotherapy, outperforming individual inflammatory markers. Additionally, irAEs and LDH levels are significant independent prognostic factors for OS. |
| format | Article |
| id | doaj-art-7ee763f01c084750ae23bb5df5c405da |
| institution | OA Journals |
| issn | 2398-8835 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-7ee763f01c084750ae23bb5df5c405da2025-08-20T02:11:03ZengWileyHealth Science Reports2398-88352025-04-0184n/an/a10.1002/hsr2.70713The Predictive Significance of Various Prognostic Scoring Systems on the Efficacy of Immunotherapy in Non‐Small Cell Lung Cancer Patients: A Retrospective StudyJianying Liu0Jinzhan Chen1Congyi Xie2Haiyan Chen3Shuwen Yang4Hongni Jiang5Yijiao Xu6Zhongshan Hospital (Xiamen) Fudan University Xiamen ChinaZhongshan Hospital (Xiamen) Fudan University Xiamen ChinaZhongshan Hospital (Xiamen) Fudan University Xiamen ChinaZhongshan Hospital (Xiamen) Fudan University Xiamen ChinaZhongshan Hospital (Xiamen) Fudan University Xiamen ChinaZhongshan Hospital (Xiamen) Fudan University Xiamen ChinaZhongshan Hospital (Xiamen) Fudan University Xiamen ChinaABSTRACT Background and Aims To evaluate the efficacy and prognostic value of various immunoprognostic scoring systems—Lung Immune Prognostic Index (LIPI), modified Glasgow Prognostic Score (mGPS), and Gustave Roussy Immune Score (GRIm)—in non‐small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs). Methods We conducted a retrospective analysis of clinical data from 219 NSCLC patients treated with ICIs at Zhongshan Hospital (Xiamen), Fudan University from June 1, 2019 to January 31, 2024. The therapeutic efficacy and predictive capabilities of the scoring systems were assessed using Kaplan–Meier curves, Cox proportional hazards models, time‐dependent ROC curves, and random survival forest models. Results The median follow‐up was 29 months (IQR: 25.96–32.04), resulting in 93 observed deaths. Both LIPI and GRIm scores correlated with declining overall survival (OS) and progression‐free survival (PFS) as risk levels increased. LIPI demonstrated superior predictive performance at 12, 24, and 36 months (AUC: 0.70, 0.62, 0.61, respectively). Multivariate analysis identified immune‐related adverse events (irAEs) and lactate dehydrogenase (LDH) levels as independent prognostic factors for OS. Conclusion LIPI serves as an effective prognostic tool for NSCLC patients receiving immunotherapy, outperforming individual inflammatory markers. Additionally, irAEs and LDH levels are significant independent prognostic factors for OS.https://doi.org/10.1002/hsr2.70713Gustave Roussy Immune Scoreimmune checkpoint inhibitorsLung Immune Prognostic Indexmodified Glasgow Prognostic Scorenon‐small cell lung cancerprognostic analysis |
| spellingShingle | Jianying Liu Jinzhan Chen Congyi Xie Haiyan Chen Shuwen Yang Hongni Jiang Yijiao Xu The Predictive Significance of Various Prognostic Scoring Systems on the Efficacy of Immunotherapy in Non‐Small Cell Lung Cancer Patients: A Retrospective Study Health Science Reports Gustave Roussy Immune Score immune checkpoint inhibitors Lung Immune Prognostic Index modified Glasgow Prognostic Score non‐small cell lung cancer prognostic analysis |
| title | The Predictive Significance of Various Prognostic Scoring Systems on the Efficacy of Immunotherapy in Non‐Small Cell Lung Cancer Patients: A Retrospective Study |
| title_full | The Predictive Significance of Various Prognostic Scoring Systems on the Efficacy of Immunotherapy in Non‐Small Cell Lung Cancer Patients: A Retrospective Study |
| title_fullStr | The Predictive Significance of Various Prognostic Scoring Systems on the Efficacy of Immunotherapy in Non‐Small Cell Lung Cancer Patients: A Retrospective Study |
| title_full_unstemmed | The Predictive Significance of Various Prognostic Scoring Systems on the Efficacy of Immunotherapy in Non‐Small Cell Lung Cancer Patients: A Retrospective Study |
| title_short | The Predictive Significance of Various Prognostic Scoring Systems on the Efficacy of Immunotherapy in Non‐Small Cell Lung Cancer Patients: A Retrospective Study |
| title_sort | predictive significance of various prognostic scoring systems on the efficacy of immunotherapy in non small cell lung cancer patients a retrospective study |
| topic | Gustave Roussy Immune Score immune checkpoint inhibitors Lung Immune Prognostic Index modified Glasgow Prognostic Score non‐small cell lung cancer prognostic analysis |
| url | https://doi.org/10.1002/hsr2.70713 |
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