Physiological skin FDG uptake: A quantitative and regional distribution assessment using PET/MRI.
<h4>Purpose</h4>To retrospectively assess the repeatability of physiological F-18 labeled fluorodeoxyglucose (FDG) uptake in the skin on positron emission tomography/magnetic resonance imaging (PET/MRI) and explore its regional distribution and relationship with sex and age.<h4>Met...
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Public Library of Science (PLoS)
2021-01-01
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| author | Munenobu Nogami Feibi Zeng Junko Inukai Yoshiaki Watanabe Mizuho Nishio Tomonori Kanda Yoshiko R Ueno Keitaro Sofue Atsushi K Kono Masatoshi Hori Akihito Ohnishi Kazuhiro Kubo Takako Kurimoto Takamichi Murakami |
| author_facet | Munenobu Nogami Feibi Zeng Junko Inukai Yoshiaki Watanabe Mizuho Nishio Tomonori Kanda Yoshiko R Ueno Keitaro Sofue Atsushi K Kono Masatoshi Hori Akihito Ohnishi Kazuhiro Kubo Takako Kurimoto Takamichi Murakami |
| author_sort | Munenobu Nogami |
| collection | DOAJ |
| description | <h4>Purpose</h4>To retrospectively assess the repeatability of physiological F-18 labeled fluorodeoxyglucose (FDG) uptake in the skin on positron emission tomography/magnetic resonance imaging (PET/MRI) and explore its regional distribution and relationship with sex and age.<h4>Methods</h4>Out of 562 examinations with normal FDG distribution on whole-body PET/MRI, 74 repeated examinations were evaluated to assess the repeatability and regional distribution of physiological skin uptake. Furthermore, 224 examinations were evaluated to compare differences in the uptake due to sex and age. Skin segmentation on PET was performed as body-surface contouring on an MR-based attenuation correction map using an off-line reconstruction software. Bland-Altman plots were created for the repeatability assessment. Kruskal-Wallis test was performed to compare the maximum standardized uptake value (SUVmax) with regional distribution, age, and sex.<h4>Results</h4>The limits of agreement for the difference in SUVmean and SUVmax of the skin were less than 30%. The highest SUVmax was observed in the face (3.09±1.04), followed by the scalp (2.07±0.53). The SUVmax in the face of boys aged 0-9 years and 10-20 years (1.33±0.64 and 2.05±1.00, respectively) and girls aged 0-9 years (0.98±0.38) was significantly lower than that of men aged ≥20 years and girls aged ≥10 years (p<0.001). In women, the SUVmax of the face (2.31±0.71) of ≥70-year-olds was significantly lower than that of 30-39-year-olds (3.83±0.82) (p<0.05).<h4>Conclusion</h4>PET/MRI enabled the quantitative analysis of skin FDG uptake with repeatability. The degree of physiological FDG uptake in the skin was the highest in the face and varied between sexes. Although attention to differences in body habitus between age groups is needed, skin FDG uptake also depended on age. |
| format | Article |
| id | doaj-art-7ee6b708756849fba686e7d25f3bb0be |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
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| spelling | doaj-art-7ee6b708756849fba686e7d25f3bb0be2025-08-20T02:17:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01163e024930410.1371/journal.pone.0249304Physiological skin FDG uptake: A quantitative and regional distribution assessment using PET/MRI.Munenobu NogamiFeibi ZengJunko InukaiYoshiaki WatanabeMizuho NishioTomonori KandaYoshiko R UenoKeitaro SofueAtsushi K KonoMasatoshi HoriAkihito OhnishiKazuhiro KuboTakako KurimotoTakamichi Murakami<h4>Purpose</h4>To retrospectively assess the repeatability of physiological F-18 labeled fluorodeoxyglucose (FDG) uptake in the skin on positron emission tomography/magnetic resonance imaging (PET/MRI) and explore its regional distribution and relationship with sex and age.<h4>Methods</h4>Out of 562 examinations with normal FDG distribution on whole-body PET/MRI, 74 repeated examinations were evaluated to assess the repeatability and regional distribution of physiological skin uptake. Furthermore, 224 examinations were evaluated to compare differences in the uptake due to sex and age. Skin segmentation on PET was performed as body-surface contouring on an MR-based attenuation correction map using an off-line reconstruction software. Bland-Altman plots were created for the repeatability assessment. Kruskal-Wallis test was performed to compare the maximum standardized uptake value (SUVmax) with regional distribution, age, and sex.<h4>Results</h4>The limits of agreement for the difference in SUVmean and SUVmax of the skin were less than 30%. The highest SUVmax was observed in the face (3.09±1.04), followed by the scalp (2.07±0.53). The SUVmax in the face of boys aged 0-9 years and 10-20 years (1.33±0.64 and 2.05±1.00, respectively) and girls aged 0-9 years (0.98±0.38) was significantly lower than that of men aged ≥20 years and girls aged ≥10 years (p<0.001). In women, the SUVmax of the face (2.31±0.71) of ≥70-year-olds was significantly lower than that of 30-39-year-olds (3.83±0.82) (p<0.05).<h4>Conclusion</h4>PET/MRI enabled the quantitative analysis of skin FDG uptake with repeatability. The degree of physiological FDG uptake in the skin was the highest in the face and varied between sexes. Although attention to differences in body habitus between age groups is needed, skin FDG uptake also depended on age.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0249304&type=printable |
| spellingShingle | Munenobu Nogami Feibi Zeng Junko Inukai Yoshiaki Watanabe Mizuho Nishio Tomonori Kanda Yoshiko R Ueno Keitaro Sofue Atsushi K Kono Masatoshi Hori Akihito Ohnishi Kazuhiro Kubo Takako Kurimoto Takamichi Murakami Physiological skin FDG uptake: A quantitative and regional distribution assessment using PET/MRI. PLoS ONE |
| title | Physiological skin FDG uptake: A quantitative and regional distribution assessment using PET/MRI. |
| title_full | Physiological skin FDG uptake: A quantitative and regional distribution assessment using PET/MRI. |
| title_fullStr | Physiological skin FDG uptake: A quantitative and regional distribution assessment using PET/MRI. |
| title_full_unstemmed | Physiological skin FDG uptake: A quantitative and regional distribution assessment using PET/MRI. |
| title_short | Physiological skin FDG uptake: A quantitative and regional distribution assessment using PET/MRI. |
| title_sort | physiological skin fdg uptake a quantitative and regional distribution assessment using pet mri |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0249304&type=printable |
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