P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis
The role of p53 family proteins, both in the pathogenesis of chronic lymphoproliferative disorders, and in aspects of the growi ng interest in thetherapeutic potential of so-called small molecules capable of influencing the regulatory "relationship" of p53, MDM2, p21 and P UMA is currently...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2014-07-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/92 |
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| _version_ | 1849241211760541696 |
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| author | P. M. Kondratovskiy A. I. Dubikov A. Yu. Doroshevskaya |
| author_facet | P. M. Kondratovskiy A. I. Dubikov A. Yu. Doroshevskaya |
| author_sort | P. M. Kondratovskiy |
| collection | DOAJ |
| description | The role of p53 family proteins, both in the pathogenesis of chronic lymphoproliferative disorders, and in aspects of the growi ng interest in thetherapeutic potential of so-called small molecules capable of influencing the regulatory "relationship" of p53, MDM2, p21 and P UMA is currently actively debated. The article is an attempt to summarize the data on experimental tumor and mouse models and availablen ithe l iterature results of studies using human lymphoid tumors. Prognostic significance of p53 family proteins expression in lymphoproliferativ e diseases and possible therapeutic approaches using the features of the p53 relationship with regulators and effectors genes are considered. |
| format | Article |
| id | doaj-art-7ee37d92d2194f508c0b68f8cb4764d4 |
| institution | Kabale University |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-7ee37d92d2194f508c0b68f8cb4764d42025-08-20T04:00:14ZrusABV-pressОнкогематология1818-83462413-40232014-07-0163657510.17650/1818-8346-2011-6-3-65-75107P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesisP. M. Kondratovskiy0A. I. Dubikov1A. Yu. Doroshevskaya2Vladivostok State Medical UniversityVladivostok State Medical UniversityVladivostok State Medical UniversityThe role of p53 family proteins, both in the pathogenesis of chronic lymphoproliferative disorders, and in aspects of the growi ng interest in thetherapeutic potential of so-called small molecules capable of influencing the regulatory "relationship" of p53, MDM2, p21 and P UMA is currently actively debated. The article is an attempt to summarize the data on experimental tumor and mouse models and availablen ithe l iterature results of studies using human lymphoid tumors. Prognostic significance of p53 family proteins expression in lymphoproliferativ e diseases and possible therapeutic approaches using the features of the p53 relationship with regulators and effectors genes are considered.https://oncohematology.abvpress.ru/ongm/article/view/92chronic lymphoproliferative diseaseslymphomaschronic lymphocytic leukemiaapoptosisр53mdm2p21puma |
| spellingShingle | P. M. Kondratovskiy A. I. Dubikov A. Yu. Doroshevskaya P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis Онкогематология chronic lymphoproliferative diseases lymphomas chronic lymphocytic leukemia apoptosis р53 mdm2 p21 puma |
| title | P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis |
| title_full | P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis |
| title_fullStr | P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis |
| title_full_unstemmed | P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis |
| title_short | P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis |
| title_sort | p53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis |
| topic | chronic lymphoproliferative diseases lymphomas chronic lymphocytic leukemia apoptosis р53 mdm2 p21 puma |
| url | https://oncohematology.abvpress.ru/ongm/article/view/92 |
| work_keys_str_mv | AT pmkondratovskiy p53pathwaychangesandtheirinfluenceonchroniclymphoproliferativediseasespathogenesis AT aidubikov p53pathwaychangesandtheirinfluenceonchroniclymphoproliferativediseasespathogenesis AT ayudoroshevskaya p53pathwaychangesandtheirinfluenceonchroniclymphoproliferativediseasespathogenesis |