BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication

BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication

Abstract Mono-methylation of histone H4 lysine 20 (H4K20me1) regulates DNA replication, cell cycle progression and DNA damage repair. How exactly H4K20me1 regulates these biological processes remains unclear. Here, we report that an evolutionarily conserved tandem Tudor domain (TTD) in BAHCC1 (BAHCC...

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Bibliographic Details
Main Authors: Dongxu Li, Zhi-Min Zhang, Liu Mei, Yao Yu, Yiran Guo, Samuel G. Mackintosh, Jianbin Chen, David F. Allison, Arum Kim, Aaron J. Storey, Ricky D. Edmondson, Stephanie D. Byrum, Alan J. Tackett, Ling Cai, Jeanette G. Cook, Jikui Song, Gang Greg Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61284-1
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