Prognostic Value of BRCA1 and BRCA2 Gene Mutations in Prostate Cancer: a Literature Review
Prostate malignancies aggressively grow worldwide frequently occurring inoperable at diagnosis. A proper choice of treatment strategy is currently a challenge. Metastatic castration-resistant prostate cancer remains fatal and poor-prognosis, albeit the list of chemotherapeutic agents and androgen re...
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| Format: | Article |
| Language: | English |
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Bashkir State Medical University
2021-05-01
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| Series: | Креативная хирургия и онкология |
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| Online Access: | https://www.surgonco.ru/jour/article/view/589 |
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| author | M. V. Loginova V. N. Pavlov I. R. Gilyazova |
| author_facet | M. V. Loginova V. N. Pavlov I. R. Gilyazova |
| author_sort | M. V. Loginova |
| collection | DOAJ |
| description | Prostate malignancies aggressively grow worldwide frequently occurring inoperable at diagnosis. A proper choice of treatment strategy is currently a challenge. Metastatic castration-resistant prostate cancer remains fatal and poor-prognosis, albeit the list of chemotherapeutic agents and androgen receptor signalling inhibitors has recently been extending towards a certain therapeutic success. Numerous studies suggest a frequent association of the unfavourable prognosis with germline or somatic damage of DNA repair genes. Such are mutations in the BRCA1 and BRCA2 genes bearing important clinical implications for the patient outcome through an adverse clinical manifest of primary tumours and poor treatment in metastatic castration-resistant prostate cancer. This review attempts to describe the BRCA1/2 mutations in prostate cancer with a focus on their prognostic value. |
| format | Article |
| id | doaj-art-7eddab9131b3441fae480bcf0de40e1b |
| institution | DOAJ |
| issn | 2076-3093 2307-0501 |
| language | English |
| publishDate | 2021-05-01 |
| publisher | Bashkir State Medical University |
| record_format | Article |
| series | Креативная хирургия и онкология |
| spelling | doaj-art-7eddab9131b3441fae480bcf0de40e1b2025-08-20T02:53:29ZengBashkir State Medical UniversityКреативная хирургия и онкология2076-30932307-05012021-05-0111218318710.24060/2076-3093-2021-11-2-183-187434Prognostic Value of BRCA1 and BRCA2 Gene Mutations in Prostate Cancer: a Literature ReviewM. V. Loginova0V. N. Pavlov1I. R. Gilyazova2Republican Clinical Oncological Dispensary; Bashkir State Medical UniversityBashkir State Medical UniversityInstitute of Biochemistry and Genetics of Ufa Federal Research Centre of the Russian Academy of SciencesProstate malignancies aggressively grow worldwide frequently occurring inoperable at diagnosis. A proper choice of treatment strategy is currently a challenge. Metastatic castration-resistant prostate cancer remains fatal and poor-prognosis, albeit the list of chemotherapeutic agents and androgen receptor signalling inhibitors has recently been extending towards a certain therapeutic success. Numerous studies suggest a frequent association of the unfavourable prognosis with germline or somatic damage of DNA repair genes. Such are mutations in the BRCA1 and BRCA2 genes bearing important clinical implications for the patient outcome through an adverse clinical manifest of primary tumours and poor treatment in metastatic castration-resistant prostate cancer. This review attempts to describe the BRCA1/2 mutations in prostate cancer with a focus on their prognostic value.https://www.surgonco.ru/jour/article/view/589prostate cancerbrca1 genebrca2 genemetastatic castration-resistant cancerdna repairmutationgermline mutation |
| spellingShingle | M. V. Loginova V. N. Pavlov I. R. Gilyazova Prognostic Value of BRCA1 and BRCA2 Gene Mutations in Prostate Cancer: a Literature Review Креативная хирургия и онкология prostate cancer brca1 gene brca2 gene metastatic castration-resistant cancer dna repair mutation germline mutation |
| title | Prognostic Value of BRCA1 and BRCA2 Gene Mutations in Prostate Cancer: a Literature Review |
| title_full | Prognostic Value of BRCA1 and BRCA2 Gene Mutations in Prostate Cancer: a Literature Review |
| title_fullStr | Prognostic Value of BRCA1 and BRCA2 Gene Mutations in Prostate Cancer: a Literature Review |
| title_full_unstemmed | Prognostic Value of BRCA1 and BRCA2 Gene Mutations in Prostate Cancer: a Literature Review |
| title_short | Prognostic Value of BRCA1 and BRCA2 Gene Mutations in Prostate Cancer: a Literature Review |
| title_sort | prognostic value of brca1 and brca2 gene mutations in prostate cancer a literature review |
| topic | prostate cancer brca1 gene brca2 gene metastatic castration-resistant cancer dna repair mutation germline mutation |
| url | https://www.surgonco.ru/jour/article/view/589 |
| work_keys_str_mv | AT mvloginova prognosticvalueofbrca1andbrca2genemutationsinprostatecanceraliteraturereview AT vnpavlov prognosticvalueofbrca1andbrca2genemutationsinprostatecanceraliteraturereview AT irgilyazova prognosticvalueofbrca1andbrca2genemutationsinprostatecanceraliteraturereview |