The role and mechanisms of exosome microRNA in regulating metastasis within the tumor microenvironment of prostate cancer
Prostate cancer (PCa) metastasis remains a significant challenge in clinical treatment, resulting in limited effective treatment options and poor clinical outcomes. Recent studies have highlighted the important function of exosome microRNAs (miRNAs) in governing metastatic processes within the tumor...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1580314/full |
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| author | Yongcheng Song Qinzhang Wang Bin Liang Songnian Zou |
| author_facet | Yongcheng Song Qinzhang Wang Bin Liang Songnian Zou |
| author_sort | Yongcheng Song |
| collection | DOAJ |
| description | Prostate cancer (PCa) metastasis remains a significant challenge in clinical treatment, resulting in limited effective treatment options and poor clinical outcomes. Recent studies have highlighted the important function of exosome microRNAs (miRNAs) in governing metastatic processes within the tumor microenvironment (TME). Our review examines the mechanisms by which exosomal miRNAs contribute to PCa metastasis, focusing on their involvement in regulating tumor invasion and migration, epithelial-mesenchymal transition, and modulating immune responses. The review also discusses the implications of these findings for therapeutic targeting of exosomal miRNAs, indicating that they may act as potential biomarkers for prognosis and therapeutic while offering novel avenues for treatment strategies aimed at inhibiting metastasis. By elucidating the intricate interplay between exosomal miRNAs and the TME, this review aims to providing new insights into PCa metastasis while offering a theoretical foundation for future clinical research. |
| format | Article |
| id | doaj-art-7ed370e45d98422cb05edce977650ee2 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-7ed370e45d98422cb05edce977650ee22025-08-20T03:10:22ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-06-011510.3389/fonc.2025.15803141580314The role and mechanisms of exosome microRNA in regulating metastasis within the tumor microenvironment of prostate cancerYongcheng Song0Qinzhang Wang1Bin Liang2Songnian Zou3Medical College, Shihezi University, Shihezi, ChinaThe First Affiliated Hospital of Shihezi University, Shihezi, ChinaDepartment of Urology, Changzhou Cancer (Fourth People’s) Hospital, Changzhou, Jiangsu, ChinaDepartment of Urology, Changzhou Cancer (Fourth People’s) Hospital, Changzhou, Jiangsu, ChinaProstate cancer (PCa) metastasis remains a significant challenge in clinical treatment, resulting in limited effective treatment options and poor clinical outcomes. Recent studies have highlighted the important function of exosome microRNAs (miRNAs) in governing metastatic processes within the tumor microenvironment (TME). Our review examines the mechanisms by which exosomal miRNAs contribute to PCa metastasis, focusing on their involvement in regulating tumor invasion and migration, epithelial-mesenchymal transition, and modulating immune responses. The review also discusses the implications of these findings for therapeutic targeting of exosomal miRNAs, indicating that they may act as potential biomarkers for prognosis and therapeutic while offering novel avenues for treatment strategies aimed at inhibiting metastasis. By elucidating the intricate interplay between exosomal miRNAs and the TME, this review aims to providing new insights into PCa metastasis while offering a theoretical foundation for future clinical research.https://www.frontiersin.org/articles/10.3389/fonc.2025.1580314/fullPCAexosome microRNAmetastasistumor microenvironmentepithelialmesenchymal transition |
| spellingShingle | Yongcheng Song Qinzhang Wang Bin Liang Songnian Zou The role and mechanisms of exosome microRNA in regulating metastasis within the tumor microenvironment of prostate cancer Frontiers in Oncology PCA exosome microRNA metastasis tumor microenvironment epithelialmesenchymal transition |
| title | The role and mechanisms of exosome microRNA in regulating metastasis within the tumor microenvironment of prostate cancer |
| title_full | The role and mechanisms of exosome microRNA in regulating metastasis within the tumor microenvironment of prostate cancer |
| title_fullStr | The role and mechanisms of exosome microRNA in regulating metastasis within the tumor microenvironment of prostate cancer |
| title_full_unstemmed | The role and mechanisms of exosome microRNA in regulating metastasis within the tumor microenvironment of prostate cancer |
| title_short | The role and mechanisms of exosome microRNA in regulating metastasis within the tumor microenvironment of prostate cancer |
| title_sort | role and mechanisms of exosome microrna in regulating metastasis within the tumor microenvironment of prostate cancer |
| topic | PCA exosome microRNA metastasis tumor microenvironment epithelialmesenchymal transition |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1580314/full |
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