Tanzanian gut microbiota profiles linked to high but rapidly waning yellow fever antibody titers
Abstract Vaccine responses vary across populations and are influenced by numerous intrinsic and extrinsic factors, including the gut microbiota. However, studies linking microbiota composition to vaccine immunogenicity in low- and middle-income countries are sparse. In this study, we examined the gu...
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Nature Portfolio
2025-06-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-025-00687-w |
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| author | Jeremia J. Pyuza Marloes M. A. R. van Dorst David Barnett Koen Stam Mikhael Manurung Linda Wammes Marion König Yvonne Kruize Nikuntufya Andongolile Anastazia Ngowi Elichilia R. Shao Vesla I. Kullaya Alex Mremi Pancras C. W. Hogendoorn Sia E. Msuya Simon P. Jochems John Penders Maria Yazdanbakhsh Wouter A. A. de Steenhuijsen Piters |
| author_facet | Jeremia J. Pyuza Marloes M. A. R. van Dorst David Barnett Koen Stam Mikhael Manurung Linda Wammes Marion König Yvonne Kruize Nikuntufya Andongolile Anastazia Ngowi Elichilia R. Shao Vesla I. Kullaya Alex Mremi Pancras C. W. Hogendoorn Sia E. Msuya Simon P. Jochems John Penders Maria Yazdanbakhsh Wouter A. A. de Steenhuijsen Piters |
| author_sort | Jeremia J. Pyuza |
| collection | DOAJ |
| description | Abstract Vaccine responses vary across populations and are influenced by numerous intrinsic and extrinsic factors, including the gut microbiota. However, studies linking microbiota composition to vaccine immunogenicity in low- and middle-income countries are sparse. In this study, we examined the gut microbiota of 143 healthy rural and urban living Tanzanians who participated in a yellow fever vaccine (YF-17D) trial. We found significant differences in gut microbiota profiles between rural and urban participants. Rural-associated microbiota showed higher diversity and enrichment of taxa like Prevotella and Succinivibrio, which were linked to dietary intake patterns. Yellow fever neutralizing antibody titers were higher in rural compared to urban participants. Interestingly, a subset of urban individuals with a rural-like microbiota had higher antibody titers and faster antibody waning than those with a more industrialized microbiota. These findings suggest that gut microbiota composition might be linked to vaccine immunogenicity, potentially outweighing the influence of living location. |
| format | Article |
| id | doaj-art-7ecf73871b004985bf35075cd699f0e7 |
| institution | OA Journals |
| issn | 2055-5008 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj-art-7ecf73871b004985bf35075cd699f0e72025-08-20T02:37:13ZengNature Portfolionpj Biofilms and Microbiomes2055-50082025-06-0111111510.1038/s41522-025-00687-wTanzanian gut microbiota profiles linked to high but rapidly waning yellow fever antibody titersJeremia J. Pyuza0Marloes M. A. R. van Dorst1David Barnett2Koen Stam3Mikhael Manurung4Linda Wammes5Marion König6Yvonne Kruize7Nikuntufya Andongolile8Anastazia Ngowi9Elichilia R. Shao10Vesla I. Kullaya11Alex Mremi12Pancras C. W. Hogendoorn13Sia E. Msuya14Simon P. Jochems15John Penders16Maria Yazdanbakhsh17Wouter A. A. de Steenhuijsen Piters18Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical CenterLeiden University Center for Infectious Diseases (LUCID), Leiden University Medical CenterDepartment of Medical Microbiology, Infectious Diseases and Infection Prevention, NUTRIM Research Institute on Nutrition and Translational Research in Metabolism, Maastricht University Medical CenterLeiden University Center for Infectious Diseases (LUCID), Leiden University Medical CenterLeiden University Center for Infectious Diseases (LUCID), Leiden University Medical CenterLeiden University Center for Infectious Diseases (LUCID), Leiden University Medical CenterLeiden University Center for Infectious Diseases (LUCID), Leiden University Medical CenterLeiden University Center for Infectious Diseases (LUCID), Leiden University Medical CenterDepartment of Community Medicine, Kilimanjaro Christian Medical Centre (KCMC)Department of Community Medicine, Kilimanjaro Christian Medical Centre (KCMC)Department of Internal Medicine, KCMC UniversityKilimanjaro Clinical Research Institute (KCRI), Kilimanjaro Christian Medical Centre (KCMC)Department of Pathology, Kilimanjaro Christian Medical Centre (KCMC)Department of Pathology, Leiden University Medical Center (LUMC)School of Public Health, KCMC UniversityLeiden University Center for Infectious Diseases (LUCID), Leiden University Medical CenterDepartment of Medical Microbiology, Infectious Diseases and Infection Prevention, NUTRIM Research Institute on Nutrition and Translational Research in Metabolism, Maastricht University Medical CenterLeiden University Center for Infectious Diseases (LUCID), Leiden University Medical CenterLeiden University Center for Infectious Diseases (LUCID), Leiden University Medical CenterAbstract Vaccine responses vary across populations and are influenced by numerous intrinsic and extrinsic factors, including the gut microbiota. However, studies linking microbiota composition to vaccine immunogenicity in low- and middle-income countries are sparse. In this study, we examined the gut microbiota of 143 healthy rural and urban living Tanzanians who participated in a yellow fever vaccine (YF-17D) trial. We found significant differences in gut microbiota profiles between rural and urban participants. Rural-associated microbiota showed higher diversity and enrichment of taxa like Prevotella and Succinivibrio, which were linked to dietary intake patterns. Yellow fever neutralizing antibody titers were higher in rural compared to urban participants. Interestingly, a subset of urban individuals with a rural-like microbiota had higher antibody titers and faster antibody waning than those with a more industrialized microbiota. These findings suggest that gut microbiota composition might be linked to vaccine immunogenicity, potentially outweighing the influence of living location.https://doi.org/10.1038/s41522-025-00687-w |
| spellingShingle | Jeremia J. Pyuza Marloes M. A. R. van Dorst David Barnett Koen Stam Mikhael Manurung Linda Wammes Marion König Yvonne Kruize Nikuntufya Andongolile Anastazia Ngowi Elichilia R. Shao Vesla I. Kullaya Alex Mremi Pancras C. W. Hogendoorn Sia E. Msuya Simon P. Jochems John Penders Maria Yazdanbakhsh Wouter A. A. de Steenhuijsen Piters Tanzanian gut microbiota profiles linked to high but rapidly waning yellow fever antibody titers npj Biofilms and Microbiomes |
| title | Tanzanian gut microbiota profiles linked to high but rapidly waning yellow fever antibody titers |
| title_full | Tanzanian gut microbiota profiles linked to high but rapidly waning yellow fever antibody titers |
| title_fullStr | Tanzanian gut microbiota profiles linked to high but rapidly waning yellow fever antibody titers |
| title_full_unstemmed | Tanzanian gut microbiota profiles linked to high but rapidly waning yellow fever antibody titers |
| title_short | Tanzanian gut microbiota profiles linked to high but rapidly waning yellow fever antibody titers |
| title_sort | tanzanian gut microbiota profiles linked to high but rapidly waning yellow fever antibody titers |
| url | https://doi.org/10.1038/s41522-025-00687-w |
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