Epithelial–mesenchymal transition and gastric cancer stem cell
Gastric cancer remains a big health problem in China. Gastric cancer cells contain a small subpopulation of cells that exhibit capabilities of differentiation and tumorigenicity. A putative explanation for ineffective therapy is the presence of cancer stem-like cells. Side population cells, which ha...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-04-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317698373 |
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| _version_ | 1849250908251095040 |
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| author | Pu Xia Xiao-Yan Xu |
| author_facet | Pu Xia Xiao-Yan Xu |
| author_sort | Pu Xia |
| collection | DOAJ |
| description | Gastric cancer remains a big health problem in China. Gastric cancer cells contain a small subpopulation of cells that exhibit capabilities of differentiation and tumorigenicity. A putative explanation for ineffective therapy is the presence of cancer stem-like cells. Side population cells, which have cancer stem-like cells’ property, are characterized by the high efflux ability of Hoechst 33342 dye. Side population cells have been isolated from gastric cancer cell lines in previous studies. The epithelial–mesenchymal transition is very important in the invasion and metastasis of epithelial-derived cancers. More and more studies showed that gastric cancer stem-like cells possess high invasive ability and epithelial–mesenchymal transition property. A brief overview of the recent advancements in gastric cancer stem-like cells and epithelial–mesenchymal transition will be helpful for providing novel insight into gastric cancer treatment. |
| format | Article |
| id | doaj-art-7ec79687976a4591a5211fe7a3e7f91b |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-7ec79687976a4591a5211fe7a3e7f91b2025-08-20T03:57:08ZengSAGE PublishingTumor Biology1423-03802017-04-013910.1177/1010428317698373Epithelial–mesenchymal transition and gastric cancer stem cellPu Xia0Xiao-Yan Xu1Department of Cell Biology, College of Basic Medical Science, Liaoning Medical University, Jinzhou, P.R. ChinaDepartment of Pathophysiology, College of Basic Medical Sciences, China Medical University, Shenyang, P.R. ChinaGastric cancer remains a big health problem in China. Gastric cancer cells contain a small subpopulation of cells that exhibit capabilities of differentiation and tumorigenicity. A putative explanation for ineffective therapy is the presence of cancer stem-like cells. Side population cells, which have cancer stem-like cells’ property, are characterized by the high efflux ability of Hoechst 33342 dye. Side population cells have been isolated from gastric cancer cell lines in previous studies. The epithelial–mesenchymal transition is very important in the invasion and metastasis of epithelial-derived cancers. More and more studies showed that gastric cancer stem-like cells possess high invasive ability and epithelial–mesenchymal transition property. A brief overview of the recent advancements in gastric cancer stem-like cells and epithelial–mesenchymal transition will be helpful for providing novel insight into gastric cancer treatment.https://doi.org/10.1177/1010428317698373 |
| spellingShingle | Pu Xia Xiao-Yan Xu Epithelial–mesenchymal transition and gastric cancer stem cell Tumor Biology |
| title | Epithelial–mesenchymal transition and gastric cancer stem cell |
| title_full | Epithelial–mesenchymal transition and gastric cancer stem cell |
| title_fullStr | Epithelial–mesenchymal transition and gastric cancer stem cell |
| title_full_unstemmed | Epithelial–mesenchymal transition and gastric cancer stem cell |
| title_short | Epithelial–mesenchymal transition and gastric cancer stem cell |
| title_sort | epithelial mesenchymal transition and gastric cancer stem cell |
| url | https://doi.org/10.1177/1010428317698373 |
| work_keys_str_mv | AT puxia epithelialmesenchymaltransitionandgastriccancerstemcell AT xiaoyanxu epithelialmesenchymaltransitionandgastriccancerstemcell |