Comparison of Bone Mineral Density in Thalassemia Major Patients with Healthy Controls
Chronic hemoglobinopathies like thalassemia are associated with many osteopathies like osteoporosis. Methods. This observational study was carried out to compare the bone mineral density (BMD) in transfusion dependent thalassemics with that of healthy controls. Thirty-two thalassemia patients, aged...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2015/648349 |
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| author | Mahesh Chand Meena Alok Hemal Mukul Satija Shilpa Khanna Arora Shahina Bano |
| author_facet | Mahesh Chand Meena Alok Hemal Mukul Satija Shilpa Khanna Arora Shahina Bano |
| author_sort | Mahesh Chand Meena |
| collection | DOAJ |
| description | Chronic hemoglobinopathies like thalassemia are associated with many osteopathies like osteoporosis. Methods. This observational study was carried out to compare the bone mineral density (BMD) in transfusion dependent thalassemics with that of healthy controls. Thirty-two thalassemia patients, aged 2–18 years, and 32 age and sex matched controls were studied. The bone mineral concentration (BMC) and BMD were assessed at lumbar spine, distal radius, and neck of femur. Biochemical parameters like serum calcium and vitamin D levels were also assessed. Results. The BMC of neck of femur was significantly low in cases in comparison to controls. We also observed significantly lower BMD at the lumbar spine in cases in comparison to controls. A significantly positive correlation was observed between serum calcium levels and BMD at neck of femur. Conclusion. Hence, low serum calcium may be used as a predictor of low BMD especially in populations where incidence of hypovitaminosis D is very high. |
| format | Article |
| id | doaj-art-7ec4b455e9bc4a09b4a6ea1f84a098c5 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-7ec4b455e9bc4a09b4a6ea1f84a098c52025-02-03T01:25:43ZengWileyAdvances in Hematology1687-91041687-91122015-01-01201510.1155/2015/648349648349Comparison of Bone Mineral Density in Thalassemia Major Patients with Healthy ControlsMahesh Chand Meena0Alok Hemal1Mukul Satija2Shilpa Khanna Arora3Shahina Bano4Department of Pediatrics, PGIMER and Dr. RML Hospital, New Delhi 110001, IndiaDepartment of Pediatrics, PGIMER and Dr. RML Hospital, New Delhi 110001, IndiaDepartment of Pediatrics, PGIMER and Dr. RML Hospital, New Delhi 110001, IndiaDepartment of Pediatrics, PGIMER and Dr. RML Hospital, New Delhi 110001, IndiaDepartment of Radiology, PGIMER and Dr. RML Hospital, New Delhi 110001, IndiaChronic hemoglobinopathies like thalassemia are associated with many osteopathies like osteoporosis. Methods. This observational study was carried out to compare the bone mineral density (BMD) in transfusion dependent thalassemics with that of healthy controls. Thirty-two thalassemia patients, aged 2–18 years, and 32 age and sex matched controls were studied. The bone mineral concentration (BMC) and BMD were assessed at lumbar spine, distal radius, and neck of femur. Biochemical parameters like serum calcium and vitamin D levels were also assessed. Results. The BMC of neck of femur was significantly low in cases in comparison to controls. We also observed significantly lower BMD at the lumbar spine in cases in comparison to controls. A significantly positive correlation was observed between serum calcium levels and BMD at neck of femur. Conclusion. Hence, low serum calcium may be used as a predictor of low BMD especially in populations where incidence of hypovitaminosis D is very high.http://dx.doi.org/10.1155/2015/648349 |
| spellingShingle | Mahesh Chand Meena Alok Hemal Mukul Satija Shilpa Khanna Arora Shahina Bano Comparison of Bone Mineral Density in Thalassemia Major Patients with Healthy Controls Advances in Hematology |
| title | Comparison of Bone Mineral Density in Thalassemia Major Patients with Healthy Controls |
| title_full | Comparison of Bone Mineral Density in Thalassemia Major Patients with Healthy Controls |
| title_fullStr | Comparison of Bone Mineral Density in Thalassemia Major Patients with Healthy Controls |
| title_full_unstemmed | Comparison of Bone Mineral Density in Thalassemia Major Patients with Healthy Controls |
| title_short | Comparison of Bone Mineral Density in Thalassemia Major Patients with Healthy Controls |
| title_sort | comparison of bone mineral density in thalassemia major patients with healthy controls |
| url | http://dx.doi.org/10.1155/2015/648349 |
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