Key amino acid residues govern the substrate selectivity of the transporter Xltr1p from Trichoderma reesei for glucose, mannose, and galactose

Key amino acid residues govern the substrate selectivity of the transporter Xltr1p from Trichoderma reesei for glucose, mannose, and galactose

This research identified four amino acid residues (Leu174, Asn297, Tyr301, and Gln291) that contribute to substrate recognition by the high-affinity glucose transporter Xltr1p from Trichoderma reesei. Potential hotspots affecting substrate specificity were selected through homology modeling, evoluti...

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Bibliographic Details
Main Authors: Wei Ma, Shiyu Yuan, Zixian Wang, Kangle Niu, Fengyi Li, Lulu Liu, Lijuan Han, Xu Fang
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Engineering Microbiology
Subjects:
Hexose transporter
Glucose
Galactose
Mannose
Transmembrane α-helix 7
Sugar transport
Online Access:http://www.sciencedirect.com/science/article/pii/S2667370324000146
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