Interplay between noise-induced sensorineural hearing loss and hypertension: pathophysiological mechanisms and therapeutic prospects
More than 5% of the global population suffers from disabling hearing loss, primarily sensorineural hearing loss (SNHL). SNHL is often caused by factors such as vascular disorders, viral infections, ototoxic drugs, systemic inflammation, age-related labyrinthine membrane degeneration, and noise-induc...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2025.1523149/full |
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| author | Carola Y. Förster Sergey Shityakov Stavros Stavrakis Verena Scheper Verena Scheper Thomas Lenarz Thomas Lenarz |
| author_facet | Carola Y. Förster Sergey Shityakov Stavros Stavrakis Verena Scheper Verena Scheper Thomas Lenarz Thomas Lenarz |
| author_sort | Carola Y. Förster |
| collection | DOAJ |
| description | More than 5% of the global population suffers from disabling hearing loss, primarily sensorineural hearing loss (SNHL). SNHL is often caused by factors such as vascular disorders, viral infections, ototoxic drugs, systemic inflammation, age-related labyrinthine membrane degeneration, and noise-induced hearing loss (NIHL). NIHL, in particular, leads to changes in blood-labyrinth-barrier (BLB) physiology, increased permeability, and various health issues, including cardiovascular disease, hypertension, diabetes, neurological disorders, and adverse reproductive outcomes. Recent advances in neuromodulation and vector-based approaches offer hope for overcoming biological barriers such as the BLB in the development of innovative treatments. Computational methods, including molecular docking, molecular dynamics simulations, QSAR/QSPR analysis with machine/deep learning algorithms, and network pharmacology, hold potential for identifying drug candidates and optimizing their interactions with BLB transporters, such as the glutamate transporter. This paper provides an overview of NIHL, focusing on its pathophysiology; its impact on membrane transporters, ion channels, and BLB structures; and associated symptoms, comorbidities, and emerging therapeutic approaches. Recent advancements in neuromodulation and vector-based strategies show great promise in overcoming biological barriers such as BLB, facilitating the development of innovative treatment options. The primary aim of this review is to examine NIHL in detail and explore its underlying mechanisms, physiological effects, and cutting-edge therapeutic strategies for its effective management and prevention. |
| format | Article |
| id | doaj-art-7ebc8722a7ed483c843f36a7b48599a1 |
| institution | OA Journals |
| issn | 1662-5102 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-7ebc8722a7ed483c843f36a7b48599a12025-08-20T02:26:10ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022025-04-011910.3389/fncel.2025.15231491523149Interplay between noise-induced sensorineural hearing loss and hypertension: pathophysiological mechanisms and therapeutic prospectsCarola Y. Förster0Sergey Shityakov1Stavros Stavrakis2Verena Scheper3Verena Scheper4Thomas Lenarz5Thomas Lenarz6Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, GermanyLaboratory of Chemoinformatics, Infochemistry Scientific Center, ITMO University, Saint Petersburg, RussiaCardiovascular Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma, OK, United StatesDepartment of Otolaryngology, Hannover Medical School, Hannover, GermanyCluster of Excellence “Hearing4all”, German Research Foundation, Hannover, GermanyDepartment of Otolaryngology, Hannover Medical School, Hannover, GermanyCluster of Excellence “Hearing4all”, German Research Foundation, Hannover, GermanyMore than 5% of the global population suffers from disabling hearing loss, primarily sensorineural hearing loss (SNHL). SNHL is often caused by factors such as vascular disorders, viral infections, ototoxic drugs, systemic inflammation, age-related labyrinthine membrane degeneration, and noise-induced hearing loss (NIHL). NIHL, in particular, leads to changes in blood-labyrinth-barrier (BLB) physiology, increased permeability, and various health issues, including cardiovascular disease, hypertension, diabetes, neurological disorders, and adverse reproductive outcomes. Recent advances in neuromodulation and vector-based approaches offer hope for overcoming biological barriers such as the BLB in the development of innovative treatments. Computational methods, including molecular docking, molecular dynamics simulations, QSAR/QSPR analysis with machine/deep learning algorithms, and network pharmacology, hold potential for identifying drug candidates and optimizing their interactions with BLB transporters, such as the glutamate transporter. This paper provides an overview of NIHL, focusing on its pathophysiology; its impact on membrane transporters, ion channels, and BLB structures; and associated symptoms, comorbidities, and emerging therapeutic approaches. Recent advancements in neuromodulation and vector-based strategies show great promise in overcoming biological barriers such as BLB, facilitating the development of innovative treatment options. The primary aim of this review is to examine NIHL in detail and explore its underlying mechanisms, physiological effects, and cutting-edge therapeutic strategies for its effective management and prevention.https://www.frontiersin.org/articles/10.3389/fncel.2025.1523149/fullnoise-induced hearing losssensorineural hearing lossblood-labyrinth barrierhypertensionvagus nerve stimulationtaVNS |
| spellingShingle | Carola Y. Förster Sergey Shityakov Stavros Stavrakis Verena Scheper Verena Scheper Thomas Lenarz Thomas Lenarz Interplay between noise-induced sensorineural hearing loss and hypertension: pathophysiological mechanisms and therapeutic prospects Frontiers in Cellular Neuroscience noise-induced hearing loss sensorineural hearing loss blood-labyrinth barrier hypertension vagus nerve stimulation taVNS |
| title | Interplay between noise-induced sensorineural hearing loss and hypertension: pathophysiological mechanisms and therapeutic prospects |
| title_full | Interplay between noise-induced sensorineural hearing loss and hypertension: pathophysiological mechanisms and therapeutic prospects |
| title_fullStr | Interplay between noise-induced sensorineural hearing loss and hypertension: pathophysiological mechanisms and therapeutic prospects |
| title_full_unstemmed | Interplay between noise-induced sensorineural hearing loss and hypertension: pathophysiological mechanisms and therapeutic prospects |
| title_short | Interplay between noise-induced sensorineural hearing loss and hypertension: pathophysiological mechanisms and therapeutic prospects |
| title_sort | interplay between noise induced sensorineural hearing loss and hypertension pathophysiological mechanisms and therapeutic prospects |
| topic | noise-induced hearing loss sensorineural hearing loss blood-labyrinth barrier hypertension vagus nerve stimulation taVNS |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2025.1523149/full |
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