Lactiplantibacillusplantarum HM-P2 influences gestational gut microbiome and microbial metabolism
IntroductionHuman milk-derived probiotics are beneficial bacteria that provide gestational health benefits, for both pregnant women and their offspring. The study aims to investigate whether the administration of human milk-derived probiotic L. plantarum HM-P2 could effectively influence gestational...
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| Format: | Article |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1489359/full |
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| author | Bin Liu Bin Liu Zhenzhen Zhang Zhenzhen Zhang Junying Zhao Junying Zhao Xianping Li Xianping Li Yaru Wang Yaru Wang Lu Liu Lu Liu Weicang Qiao Weicang Qiao Lijun Chen Lijun Chen |
| author_facet | Bin Liu Bin Liu Zhenzhen Zhang Zhenzhen Zhang Junying Zhao Junying Zhao Xianping Li Xianping Li Yaru Wang Yaru Wang Lu Liu Lu Liu Weicang Qiao Weicang Qiao Lijun Chen Lijun Chen |
| author_sort | Bin Liu |
| collection | DOAJ |
| description | IntroductionHuman milk-derived probiotics are beneficial bacteria that provide gestational health benefits, for both pregnant women and their offspring. The study aims to investigate whether the administration of human milk-derived probiotic L. plantarum HM-P2 could effectively influence gestational health.MethodsThe gestational humanized microbiome model was built by fecal microbiome transplant from gestational women into germ-free (GF) mice.ResultsHM-P2 was successfully planted and increased the top crypt depth of the colon, and microbes such as L. reuteri,Anaerofilum sp. An201, and Gemmiger were up-regulated in the HM-P2 group throughout gestation. HM-P2 significantly promoted the contents of intestinal caproic acid, bile acids, and tryptophan catabolites such as serotonin. Gut microbes were associated with these bile acids and tryptophans.DiscussionHM-P2 could modulate the microbial community and microbial metabolites in gestational humanized GF mice. This probiotic strain could be a potential gestational dietary supplement with health benefits. |
| format | Article |
| id | doaj-art-7ebc6dacd4004826bca6c41772f6f2c8 |
| institution | OA Journals |
| issn | 2296-861X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-7ebc6dacd4004826bca6c41772f6f2c82025-08-20T02:34:53ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-12-011110.3389/fnut.2024.14893591489359Lactiplantibacillusplantarum HM-P2 influences gestational gut microbiome and microbial metabolismBin Liu0Bin Liu1Zhenzhen Zhang2Zhenzhen Zhang3Junying Zhao4Junying Zhao5Xianping Li6Xianping Li7Yaru Wang8Yaru Wang9Lu Liu10Lu Liu11Weicang Qiao12Weicang Qiao13Lijun Chen14Lijun Chen15National Engineering Research Center of Dairy Health for Maternal and Child, Beijing Sanyuan Foods Co. Ltd., Beijing, ChinaBeijing Engineering Research Center of Dairy, Beijing Technical Innovation Center of Human Milk Research, Beijing Sanyuan Foods Co. Ltd., Beijing, ChinaNational Engineering Research Center of Dairy Health for Maternal and Child, Beijing Sanyuan Foods Co. Ltd., Beijing, ChinaBeijing Engineering Research Center of Dairy, Beijing Technical Innovation Center of Human Milk Research, Beijing Sanyuan Foods Co. Ltd., Beijing, ChinaNational Engineering Research Center of Dairy Health for Maternal and Child, Beijing Sanyuan Foods Co. Ltd., Beijing, ChinaBeijing Engineering Research Center of Dairy, Beijing Technical Innovation Center of Human Milk Research, Beijing Sanyuan Foods Co. Ltd., Beijing, ChinaNational Engineering Research Center of Dairy Health for Maternal and Child, Beijing Sanyuan Foods Co. Ltd., Beijing, ChinaBeijing Engineering Research Center of Dairy, Beijing Technical Innovation Center of Human Milk Research, Beijing Sanyuan Foods Co. Ltd., Beijing, ChinaNational Engineering Research Center of Dairy Health for Maternal and Child, Beijing Sanyuan Foods Co. Ltd., Beijing, ChinaBeijing Engineering Research Center of Dairy, Beijing Technical Innovation Center of Human Milk Research, Beijing Sanyuan Foods Co. Ltd., Beijing, ChinaNational Engineering Research Center of Dairy Health for Maternal and Child, Beijing Sanyuan Foods Co. Ltd., Beijing, ChinaBeijing Engineering Research Center of Dairy, Beijing Technical Innovation Center of Human Milk Research, Beijing Sanyuan Foods Co. Ltd., Beijing, ChinaNational Engineering Research Center of Dairy Health for Maternal and Child, Beijing Sanyuan Foods Co. Ltd., Beijing, ChinaBeijing Engineering Research Center of Dairy, Beijing Technical Innovation Center of Human Milk Research, Beijing Sanyuan Foods Co. Ltd., Beijing, ChinaNational Engineering Research Center of Dairy Health for Maternal and Child, Beijing Sanyuan Foods Co. Ltd., Beijing, ChinaBeijing Engineering Research Center of Dairy, Beijing Technical Innovation Center of Human Milk Research, Beijing Sanyuan Foods Co. Ltd., Beijing, ChinaIntroductionHuman milk-derived probiotics are beneficial bacteria that provide gestational health benefits, for both pregnant women and their offspring. The study aims to investigate whether the administration of human milk-derived probiotic L. plantarum HM-P2 could effectively influence gestational health.MethodsThe gestational humanized microbiome model was built by fecal microbiome transplant from gestational women into germ-free (GF) mice.ResultsHM-P2 was successfully planted and increased the top crypt depth of the colon, and microbes such as L. reuteri,Anaerofilum sp. An201, and Gemmiger were up-regulated in the HM-P2 group throughout gestation. HM-P2 significantly promoted the contents of intestinal caproic acid, bile acids, and tryptophan catabolites such as serotonin. Gut microbes were associated with these bile acids and tryptophans.DiscussionHM-P2 could modulate the microbial community and microbial metabolites in gestational humanized GF mice. This probiotic strain could be a potential gestational dietary supplement with health benefits.https://www.frontiersin.org/articles/10.3389/fnut.2024.1489359/fullprobioticsLactiplantibacillus plantarum HM-P2humanized germ-free micefecal microbiome transplantationmicrobial metabolites |
| spellingShingle | Bin Liu Bin Liu Zhenzhen Zhang Zhenzhen Zhang Junying Zhao Junying Zhao Xianping Li Xianping Li Yaru Wang Yaru Wang Lu Liu Lu Liu Weicang Qiao Weicang Qiao Lijun Chen Lijun Chen Lactiplantibacillusplantarum HM-P2 influences gestational gut microbiome and microbial metabolism Frontiers in Nutrition probiotics Lactiplantibacillus plantarum HM-P2 humanized germ-free mice fecal microbiome transplantation microbial metabolites |
| title | Lactiplantibacillusplantarum HM-P2 influences gestational gut microbiome and microbial metabolism |
| title_full | Lactiplantibacillusplantarum HM-P2 influences gestational gut microbiome and microbial metabolism |
| title_fullStr | Lactiplantibacillusplantarum HM-P2 influences gestational gut microbiome and microbial metabolism |
| title_full_unstemmed | Lactiplantibacillusplantarum HM-P2 influences gestational gut microbiome and microbial metabolism |
| title_short | Lactiplantibacillusplantarum HM-P2 influences gestational gut microbiome and microbial metabolism |
| title_sort | lactiplantibacillusplantarum hm p2 influences gestational gut microbiome and microbial metabolism |
| topic | probiotics Lactiplantibacillus plantarum HM-P2 humanized germ-free mice fecal microbiome transplantation microbial metabolites |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1489359/full |
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