Dietary selective effects manifest in the human gut microbiota from species composition to strain genetic makeup
Summary: Diet significantly influences the human gut microbiota, a key player in health. We analyzed shotgun metagenomic sequencing data from healthy individuals with long-term dietary patterns—vegan, flexitarian, or omnivore—and included detailed dietary surveys and blood biomarkers. Dietary patter...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724014189 |
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| author | Kun D. Huang Mattea Müller Pavaret Sivapornnukul Agata Anna Bielecka Lena Amend Caroline Tawk Till-Robin Lesker Andreas Hahn Till Strowig |
| author_facet | Kun D. Huang Mattea Müller Pavaret Sivapornnukul Agata Anna Bielecka Lena Amend Caroline Tawk Till-Robin Lesker Andreas Hahn Till Strowig |
| author_sort | Kun D. Huang |
| collection | DOAJ |
| description | Summary: Diet significantly influences the human gut microbiota, a key player in health. We analyzed shotgun metagenomic sequencing data from healthy individuals with long-term dietary patterns—vegan, flexitarian, or omnivore—and included detailed dietary surveys and blood biomarkers. Dietary patterns notably affected the bacterial community composition by altering the relative abundances of certain species but had a minimal impact on microbial functional repertoires. However, diet influenced microbial functionality at the strain level, with diet type linked to strain genetic variations. We also found molecular signatures of selective pressure in species enriched by specific diets. Notably, species enriched in omnivores exhibited stronger positive selection, such as multiple iron-regulating genes in the meat-favoring bacterium Odoribacter splanchnicus, an effect that was also validated in independent cohorts. Our findings offer insights into how diet shapes species and genetic diversity in the human gut microbiota. |
| format | Article |
| id | doaj-art-7ebc104560484b9dbdeba86e5f135d1b |
| institution | OA Journals |
| issn | 2211-1247 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-7ebc104560484b9dbdeba86e5f135d1b2025-08-20T02:37:51ZengElsevierCell Reports2211-12472024-12-01431211506710.1016/j.celrep.2024.115067Dietary selective effects manifest in the human gut microbiota from species composition to strain genetic makeupKun D. Huang0Mattea Müller1Pavaret Sivapornnukul2Agata Anna Bielecka3Lena Amend4Caroline Tawk5Till-Robin Lesker6Andreas Hahn7Till Strowig8Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, GermanyInstitute of Food Science and Nutrition, Leibniz University of Hannover, Hannover, GermanyDepartment of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany; Center of Excellence in Systems Microbiology (CESM), Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandDepartment of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, GermanyDepartment of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, GermanyDepartment of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, GermanyDepartment of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, GermanyInstitute of Food Science and Nutrition, Leibniz University of Hannover, Hannover, GermanyDepartment of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany; Hannover Medical School (MHH), Hannover, Germany; Centre for Individualized Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany; Corresponding authorSummary: Diet significantly influences the human gut microbiota, a key player in health. We analyzed shotgun metagenomic sequencing data from healthy individuals with long-term dietary patterns—vegan, flexitarian, or omnivore—and included detailed dietary surveys and blood biomarkers. Dietary patterns notably affected the bacterial community composition by altering the relative abundances of certain species but had a minimal impact on microbial functional repertoires. However, diet influenced microbial functionality at the strain level, with diet type linked to strain genetic variations. We also found molecular signatures of selective pressure in species enriched by specific diets. Notably, species enriched in omnivores exhibited stronger positive selection, such as multiple iron-regulating genes in the meat-favoring bacterium Odoribacter splanchnicus, an effect that was also validated in independent cohorts. Our findings offer insights into how diet shapes species and genetic diversity in the human gut microbiota.http://www.sciencedirect.com/science/article/pii/S2211124724014189CP: Microbiology |
| spellingShingle | Kun D. Huang Mattea Müller Pavaret Sivapornnukul Agata Anna Bielecka Lena Amend Caroline Tawk Till-Robin Lesker Andreas Hahn Till Strowig Dietary selective effects manifest in the human gut microbiota from species composition to strain genetic makeup Cell Reports CP: Microbiology |
| title | Dietary selective effects manifest in the human gut microbiota from species composition to strain genetic makeup |
| title_full | Dietary selective effects manifest in the human gut microbiota from species composition to strain genetic makeup |
| title_fullStr | Dietary selective effects manifest in the human gut microbiota from species composition to strain genetic makeup |
| title_full_unstemmed | Dietary selective effects manifest in the human gut microbiota from species composition to strain genetic makeup |
| title_short | Dietary selective effects manifest in the human gut microbiota from species composition to strain genetic makeup |
| title_sort | dietary selective effects manifest in the human gut microbiota from species composition to strain genetic makeup |
| topic | CP: Microbiology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724014189 |
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