Acute Brucellosis and Cirrhosis: The Triggering Event of Fatal Liver Decompensation
Cirrhotic patients are known to be particularly susceptible to infectious complications that may vary according to regional endemic patterns. Brucellosis, a common zoonosis with worldwide distribution, exhibits a predilection for the reticuloendothelial system and thus resulting in hepatic involveme...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2020/8868001 |
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| author | Maria Kosmidou Eleftherios Klouras Iro Rapti Sebastien Filippas-Ntekouan Haralampos Milionis |
| author_facet | Maria Kosmidou Eleftherios Klouras Iro Rapti Sebastien Filippas-Ntekouan Haralampos Milionis |
| author_sort | Maria Kosmidou |
| collection | DOAJ |
| description | Cirrhotic patients are known to be particularly susceptible to infectious complications that may vary according to regional endemic patterns. Brucellosis, a common zoonosis with worldwide distribution, exhibits a predilection for the reticuloendothelial system and thus resulting in hepatic involvement. We describe three cirrhotic patients in whom acute brucellosis and/or its treatment served as the triggering factor of hepatic decompensation, with deleterious effects. The patients suffered from alcoholic cirrhosis and culture-proven brucellosis. All patients came from an area endemic to brucellosis. The first patient exhibited a relapsing brucellosis course with progressive deterioration of his fragile liver function. The second patient progressed rapidly to jaundice, possibly partly attributed to antibiotic pharmacotoxicity, and died during liver transplantation. The third patient eventually succumbed to diffuse intravascular coagulation. Brucellosis can be a triggering event of fatal liver decompensation in cirrhotic patients. Enhancing health literacy of the patients, particularly in endemic areas, is of paramount importance for prevention of exposure to similar pathogens. |
| format | Article |
| id | doaj-art-7eb8dfdf34ed48cfac7b8d3868c0857d |
| institution | Kabale University |
| issn | 2090-6587 2090-6595 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hepatology |
| spelling | doaj-art-7eb8dfdf34ed48cfac7b8d3868c0857d2025-08-20T03:35:48ZengWileyCase Reports in Hepatology2090-65872090-65952020-01-01202010.1155/2020/88680018868001Acute Brucellosis and Cirrhosis: The Triggering Event of Fatal Liver DecompensationMaria Kosmidou0Eleftherios Klouras1Iro Rapti2Sebastien Filippas-Ntekouan3Haralampos Milionis4First Division of Internal Medicine, Faculty of Medicine, University of Ioannina, Ioannina, GreeceFirst Division of Internal Medicine, Faculty of Medicine, University of Ioannina, Ioannina, GreeceFirst Division of Internal Medicine, Faculty of Medicine, University of Ioannina, Ioannina, GreeceFirst Division of Internal Medicine, Faculty of Medicine, University of Ioannina, Ioannina, GreeceFirst Division of Internal Medicine, Faculty of Medicine, University of Ioannina, Ioannina, GreeceCirrhotic patients are known to be particularly susceptible to infectious complications that may vary according to regional endemic patterns. Brucellosis, a common zoonosis with worldwide distribution, exhibits a predilection for the reticuloendothelial system and thus resulting in hepatic involvement. We describe three cirrhotic patients in whom acute brucellosis and/or its treatment served as the triggering factor of hepatic decompensation, with deleterious effects. The patients suffered from alcoholic cirrhosis and culture-proven brucellosis. All patients came from an area endemic to brucellosis. The first patient exhibited a relapsing brucellosis course with progressive deterioration of his fragile liver function. The second patient progressed rapidly to jaundice, possibly partly attributed to antibiotic pharmacotoxicity, and died during liver transplantation. The third patient eventually succumbed to diffuse intravascular coagulation. Brucellosis can be a triggering event of fatal liver decompensation in cirrhotic patients. Enhancing health literacy of the patients, particularly in endemic areas, is of paramount importance for prevention of exposure to similar pathogens.http://dx.doi.org/10.1155/2020/8868001 |
| spellingShingle | Maria Kosmidou Eleftherios Klouras Iro Rapti Sebastien Filippas-Ntekouan Haralampos Milionis Acute Brucellosis and Cirrhosis: The Triggering Event of Fatal Liver Decompensation Case Reports in Hepatology |
| title | Acute Brucellosis and Cirrhosis: The Triggering Event of Fatal Liver Decompensation |
| title_full | Acute Brucellosis and Cirrhosis: The Triggering Event of Fatal Liver Decompensation |
| title_fullStr | Acute Brucellosis and Cirrhosis: The Triggering Event of Fatal Liver Decompensation |
| title_full_unstemmed | Acute Brucellosis and Cirrhosis: The Triggering Event of Fatal Liver Decompensation |
| title_short | Acute Brucellosis and Cirrhosis: The Triggering Event of Fatal Liver Decompensation |
| title_sort | acute brucellosis and cirrhosis the triggering event of fatal liver decompensation |
| url | http://dx.doi.org/10.1155/2020/8868001 |
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