PKM2-mediated metabolic reprogramming of microglia in neuroinflammation
Abstract Microglia, the resident immune cells of the central nervous system, undergo metabolic reprogramming during neuroinflammation, playing a crucial role in the pathogenesis of neurological disorders such as Parkinson’s disease. This review focuses on Pyruvate Kinase M2 (PKM2), a key glycolytic...
Saved in:
| Main Authors: | Qi Zhang, Sha-Sha Wang, Zhao Zhang, Shi-Feng Chu |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-04-01
|
| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02453-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
METABOLIC REPROGRAMMING OF MICROGLIA AND ASTROCYTES AS A FACTOR IN THE REGULATION OF NEUROINFLAMMATION IN ISCHEMIC STROKE
by: Mikhail Bobrov, et al.
Published: (2019-08-01) -
The role of PKM2-mediated metabolic reprogramming in the osteogenic differentiation of BMSCs under diabetic periodontitis conditions
by: Yanlin Zhu, et al.
Published: (2025-04-01) -
PKM2-driven metabolic reprogramming in digestive system tumors: mechanisms, therapeutic advances, and clinical challenges
by: Xinyao Huang, et al.
Published: (2025-08-01) -
AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism
by: Zongwang Zhang, et al.
Published: (2025-05-01) -
Influence of antipsychotic drugs on microglia-mediated neuroinflammation in schizophrenia: perspectives in an astrocyte–microglia co-culture model
by: Timo Jendrik Faustmann, et al.
Published: (2025-03-01)