Liver metastasized pancreatic neuroendocrine tumor in a 17‐year‐old female: A case report
Key Clinical Message Pancreatic neuroendocrine tumors (PNETs) are rare and often misdiagnosed due to their vague symptoms and tumor heterogeneity. Early detection using computed tomography (CT) is essential, particularly in regions without access to advanced diagnostic tools like immunohistochemistr...
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Wiley
2024-11-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.9545 |
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| author | Mahmoud Sultan Azad Al Hasan Nisreen Khazem |
| author_facet | Mahmoud Sultan Azad Al Hasan Nisreen Khazem |
| author_sort | Mahmoud Sultan |
| collection | DOAJ |
| description | Key Clinical Message Pancreatic neuroendocrine tumors (PNETs) are rare and often misdiagnosed due to their vague symptoms and tumor heterogeneity. Early detection using computed tomography (CT) is essential, particularly in regions without access to advanced diagnostic tools like immunohistochemistry and genetic testing. Abstract Neuroendocrine tumors (NETs) are rare tumors in adults and extremely rare in the pediatric population, as pancreatic NETs (pNETs) have an incidence rate of <0.1 per million. We present a case of a 17‐year‐old female with a liver metastasized pNET. A 17‐year‐old female with a history of intermittent abdomen‐back pain presented to the clinic with severe upper abdominal pain radiating to the shoulder. The routine tests were normal. An ultrasound showed multiple lesions in the liver, which were confirmed by a computed tomography (CT) that uncovered a pancreatic lesion too. A liver biopsy proved it was a metastasized pNET with positive NET markers on IMC staining. The metaiodobenzylguanidine (MIBG) scan flared the liver lesion. The patient was started on Octreotide long‐acting release (LAR) 30 mg once monthly. The rarity of these tumors makes their diagnosis difficult, but they should not be omitted and must be considered when there are long‐lasting symptoms that are not compatible with common illnesses. These tumors are curable in their early stages. |
| format | Article |
| id | doaj-art-7eb441de852a41d8aa20c63fbb9f8e4f |
| institution | DOAJ |
| issn | 2050-0904 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-7eb441de852a41d8aa20c63fbb9f8e4f2025-08-20T02:49:46ZengWileyClinical Case Reports2050-09042024-11-011211n/an/a10.1002/ccr3.9545Liver metastasized pancreatic neuroendocrine tumor in a 17‐year‐old female: A case reportMahmoud Sultan0Azad Al Hasan1Nisreen Khazem2Faculty of Medicine Damascus University Damascus SyriaFaculty of Medicine Damascus University Damascus SyriaFaculty of Medicine Damascus University Damascus SyriaKey Clinical Message Pancreatic neuroendocrine tumors (PNETs) are rare and often misdiagnosed due to their vague symptoms and tumor heterogeneity. Early detection using computed tomography (CT) is essential, particularly in regions without access to advanced diagnostic tools like immunohistochemistry and genetic testing. Abstract Neuroendocrine tumors (NETs) are rare tumors in adults and extremely rare in the pediatric population, as pancreatic NETs (pNETs) have an incidence rate of <0.1 per million. We present a case of a 17‐year‐old female with a liver metastasized pNET. A 17‐year‐old female with a history of intermittent abdomen‐back pain presented to the clinic with severe upper abdominal pain radiating to the shoulder. The routine tests were normal. An ultrasound showed multiple lesions in the liver, which were confirmed by a computed tomography (CT) that uncovered a pancreatic lesion too. A liver biopsy proved it was a metastasized pNET with positive NET markers on IMC staining. The metaiodobenzylguanidine (MIBG) scan flared the liver lesion. The patient was started on Octreotide long‐acting release (LAR) 30 mg once monthly. The rarity of these tumors makes their diagnosis difficult, but they should not be omitted and must be considered when there are long‐lasting symptoms that are not compatible with common illnesses. These tumors are curable in their early stages.https://doi.org/10.1002/ccr3.9545endocrinology and metabolic disordersgastroenterology/hepatologyoncologypathology and laboratory medicinepediatrics and adolescent medicine |
| spellingShingle | Mahmoud Sultan Azad Al Hasan Nisreen Khazem Liver metastasized pancreatic neuroendocrine tumor in a 17‐year‐old female: A case report Clinical Case Reports endocrinology and metabolic disorders gastroenterology/hepatology oncology pathology and laboratory medicine pediatrics and adolescent medicine |
| title | Liver metastasized pancreatic neuroendocrine tumor in a 17‐year‐old female: A case report |
| title_full | Liver metastasized pancreatic neuroendocrine tumor in a 17‐year‐old female: A case report |
| title_fullStr | Liver metastasized pancreatic neuroendocrine tumor in a 17‐year‐old female: A case report |
| title_full_unstemmed | Liver metastasized pancreatic neuroendocrine tumor in a 17‐year‐old female: A case report |
| title_short | Liver metastasized pancreatic neuroendocrine tumor in a 17‐year‐old female: A case report |
| title_sort | liver metastasized pancreatic neuroendocrine tumor in a 17 year old female a case report |
| topic | endocrinology and metabolic disorders gastroenterology/hepatology oncology pathology and laboratory medicine pediatrics and adolescent medicine |
| url | https://doi.org/10.1002/ccr3.9545 |
| work_keys_str_mv | AT mahmoudsultan livermetastasizedpancreaticneuroendocrinetumorina17yearoldfemaleacasereport AT azadalhasan livermetastasizedpancreaticneuroendocrinetumorina17yearoldfemaleacasereport AT nisreenkhazem livermetastasizedpancreaticneuroendocrinetumorina17yearoldfemaleacasereport |