Synthesis, Characterization, DNA Binding, and Photocleavage Activity of Oxorhenium (V) Complexes with α-Diimine and Quinoxaline Ligands
The complex [ReOCl3pq] (1) (where pq = 2-(2′pyridyl)quinoxaline) has been synthesized and fully characterized by UV-Vis, FTIR, 1 and 2D NMR, and cyclic voltammetry (CV). The DNA-binding properties of the complex 1 as well as of the compounds [ReOCl3bpy] (2), [ReOCl3phen] (3), and pq (4) were investi...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2010/973742 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558110622875648 |
|---|---|
| author | Christiana A. Mitsopoulou Constantinos Dagas |
| author_facet | Christiana A. Mitsopoulou Constantinos Dagas |
| author_sort | Christiana A. Mitsopoulou |
| collection | DOAJ |
| description | The complex [ReOCl3pq] (1) (where pq = 2-(2′pyridyl)quinoxaline) has been synthesized and fully characterized by UV-Vis, FTIR, 1 and 2D NMR, and cyclic voltammetry (CV). The DNA-binding properties of the complex 1 as well as of the compounds [ReOCl3bpy] (2), [ReOCl3phen] (3), and pq (4) were investigated by UV-spectrophotometric (melting curves), CV (cyclic voltammetry), and viscosity measurements. Experimental data suggest that complex 1 intercalates into the DNA base pairs. Upon irradiation, complex 1 was found to promote the cleavage of plasmid pBR 322 DNA from supercoiled form I to nicked form II. The mechanism of the DNA cleavage by complex 1 was also investigated. |
| format | Article |
| id | doaj-art-7eb310a7ebfb4a0a892b235a4ba6d8f7 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-7eb310a7ebfb4a0a892b235a4ba6d8f72025-02-03T01:33:18ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2010-01-01201010.1155/2010/973742973742Synthesis, Characterization, DNA Binding, and Photocleavage Activity of Oxorhenium (V) Complexes with α-Diimine and Quinoxaline LigandsChristiana A. Mitsopoulou0Constantinos Dagas1Laboratory of Inorganic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Zografou, Athens 157 71, GreeceLaboratory of Inorganic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Zografou, Athens 157 71, GreeceThe complex [ReOCl3pq] (1) (where pq = 2-(2′pyridyl)quinoxaline) has been synthesized and fully characterized by UV-Vis, FTIR, 1 and 2D NMR, and cyclic voltammetry (CV). The DNA-binding properties of the complex 1 as well as of the compounds [ReOCl3bpy] (2), [ReOCl3phen] (3), and pq (4) were investigated by UV-spectrophotometric (melting curves), CV (cyclic voltammetry), and viscosity measurements. Experimental data suggest that complex 1 intercalates into the DNA base pairs. Upon irradiation, complex 1 was found to promote the cleavage of plasmid pBR 322 DNA from supercoiled form I to nicked form II. The mechanism of the DNA cleavage by complex 1 was also investigated.http://dx.doi.org/10.1155/2010/973742 |
| spellingShingle | Christiana A. Mitsopoulou Constantinos Dagas Synthesis, Characterization, DNA Binding, and Photocleavage Activity of Oxorhenium (V) Complexes with α-Diimine and Quinoxaline Ligands Bioinorganic Chemistry and Applications |
| title | Synthesis, Characterization, DNA Binding, and Photocleavage Activity of Oxorhenium (V) Complexes with α-Diimine and Quinoxaline Ligands |
| title_full | Synthesis, Characterization, DNA Binding, and Photocleavage Activity of Oxorhenium (V) Complexes with α-Diimine and Quinoxaline Ligands |
| title_fullStr | Synthesis, Characterization, DNA Binding, and Photocleavage Activity of Oxorhenium (V) Complexes with α-Diimine and Quinoxaline Ligands |
| title_full_unstemmed | Synthesis, Characterization, DNA Binding, and Photocleavage Activity of Oxorhenium (V) Complexes with α-Diimine and Quinoxaline Ligands |
| title_short | Synthesis, Characterization, DNA Binding, and Photocleavage Activity of Oxorhenium (V) Complexes with α-Diimine and Quinoxaline Ligands |
| title_sort | synthesis characterization dna binding and photocleavage activity of oxorhenium v complexes with α diimine and quinoxaline ligands |
| url | http://dx.doi.org/10.1155/2010/973742 |
| work_keys_str_mv | AT christianaamitsopoulou synthesischaracterizationdnabindingandphotocleavageactivityofoxorheniumvcomplexeswithadiimineandquinoxalineligands AT constantinosdagas synthesischaracterizationdnabindingandphotocleavageactivityofoxorheniumvcomplexeswithadiimineandquinoxalineligands |