Febrile Ordeal: A Case of Human Herpesvirus 8–Induced Hemophagocytic Lymphohistiocytosis in a Cardiac Transplant Patient

Hemophagocytic lymphohistiocytosis (HLH) occurs due to the proliferation of the mononuclear phagocytic system, resulting in marked hemophagocytosis. The nonspecific clinical and laboratory findings make the diagnosis of HLH a challenge. Here, we present a postcardiac transplant patient with recurren...

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Bibliographic Details
Main Authors: Inemesit Akpan, Patrick Berchie, Rajeev Singh, Zola Nlandu
Format: Article
Language:English
Published: American College of Physicians 2025-01-01
Series:Annals of Internal Medicine: Clinical Cases
Online Access:https://www.acpjournals.org/doi/10.7326/aimcc.2024.0777
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Summary:Hemophagocytic lymphohistiocytosis (HLH) occurs due to the proliferation of the mononuclear phagocytic system, resulting in marked hemophagocytosis. The nonspecific clinical and laboratory findings make the diagnosis of HLH a challenge. Here, we present a postcardiac transplant patient with recurrent fever of unknown origin who was found to have HLH induced by human herpesvirus 8 infection. Our patient's nonspecific symptoms made it challenging to arrive at the diagnosis, which delayed management.
ISSN:2767-7664