Modulation of adult hippocampal neurogenesis by interleukin 1 signaling
Adult hippocampal neurogenesis (AHN) plays a critical role in cognition and emotional regulation. Recent studies have linked compromised AHN to numerous neurological and psychological disorders. The actions of the inflammatory cytokine interleukin-1 (IL-1) have been found to suppress AHN and antagon...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Neurobiology of Sleep and Circadian Rhythms |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451994425000124 |
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| author | Maria I. Smirnova Ning Quan |
| author_facet | Maria I. Smirnova Ning Quan |
| author_sort | Maria I. Smirnova |
| collection | DOAJ |
| description | Adult hippocampal neurogenesis (AHN) plays a critical role in cognition and emotional regulation. Recent studies have linked compromised AHN to numerous neurological and psychological disorders. The actions of the inflammatory cytokine interleukin-1 (IL-1) have been found to suppress AHN and antagonism of IL-1 signaling has been advocated as a therapeutic strategy for the treatment of neurodegenerative diseases and affective disorders. On the other hand, work from Jim Krueger's group revealed the physiological function of IL-1 in brain homeostasis, indicating the potential downside of IL-1 blockade. Current literature also shows AHN participates in normal functions of the brain in parallel to IL-1. This mini-review analyzes how IL-1 might positively or negatively modulate AHN and the implications of the relationship between IL-1 and AHN on health and disease. Specifically, we will highlight the parallels between IL-1 signaling and AHN in physiological and disease states. We propose that IL-1 signaling modulates AHN in a context-dependent manner; whereas its elevated signaling impairs neurogenesis and contributes to neurological and psychiatric disorders, its physiological role suggests potential therapeutic benefits of IL-1 antagonism must consider the preservation of the beneficial actions of IL-1. |
| format | Article |
| id | doaj-art-7eb04ecbf6df41d79258b2de6cc75c89 |
| institution | DOAJ |
| issn | 2451-9944 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Sleep and Circadian Rhythms |
| spelling | doaj-art-7eb04ecbf6df41d79258b2de6cc75c892025-08-20T03:20:22ZengElsevierNeurobiology of Sleep and Circadian Rhythms2451-99442025-05-011810012310.1016/j.nbscr.2025.100123Modulation of adult hippocampal neurogenesis by interleukin 1 signalingMaria I. Smirnova0Ning Quan1Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, 5353 Parkside Drive, Jupiter, FL, 33458, USADepartment of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, 5353 Parkside Drive, Jupiter, FL, 33458, USA; Stiles-Nicholson Brain Institute, Florida Atlantic University, Jupiter, FL, 33458, USA; Corresponding author. Stiles-Nicholson Brain Institute, Florida Atlantic University, Jupiter, FL, 33458, USA.Adult hippocampal neurogenesis (AHN) plays a critical role in cognition and emotional regulation. Recent studies have linked compromised AHN to numerous neurological and psychological disorders. The actions of the inflammatory cytokine interleukin-1 (IL-1) have been found to suppress AHN and antagonism of IL-1 signaling has been advocated as a therapeutic strategy for the treatment of neurodegenerative diseases and affective disorders. On the other hand, work from Jim Krueger's group revealed the physiological function of IL-1 in brain homeostasis, indicating the potential downside of IL-1 blockade. Current literature also shows AHN participates in normal functions of the brain in parallel to IL-1. This mini-review analyzes how IL-1 might positively or negatively modulate AHN and the implications of the relationship between IL-1 and AHN on health and disease. Specifically, we will highlight the parallels between IL-1 signaling and AHN in physiological and disease states. We propose that IL-1 signaling modulates AHN in a context-dependent manner; whereas its elevated signaling impairs neurogenesis and contributes to neurological and psychiatric disorders, its physiological role suggests potential therapeutic benefits of IL-1 antagonism must consider the preservation of the beneficial actions of IL-1.http://www.sciencedirect.com/science/article/pii/S2451994425000124 |
| spellingShingle | Maria I. Smirnova Ning Quan Modulation of adult hippocampal neurogenesis by interleukin 1 signaling Neurobiology of Sleep and Circadian Rhythms |
| title | Modulation of adult hippocampal neurogenesis by interleukin 1 signaling |
| title_full | Modulation of adult hippocampal neurogenesis by interleukin 1 signaling |
| title_fullStr | Modulation of adult hippocampal neurogenesis by interleukin 1 signaling |
| title_full_unstemmed | Modulation of adult hippocampal neurogenesis by interleukin 1 signaling |
| title_short | Modulation of adult hippocampal neurogenesis by interleukin 1 signaling |
| title_sort | modulation of adult hippocampal neurogenesis by interleukin 1 signaling |
| url | http://www.sciencedirect.com/science/article/pii/S2451994425000124 |
| work_keys_str_mv | AT mariaismirnova modulationofadulthippocampalneurogenesisbyinterleukin1signaling AT ningquan modulationofadulthippocampalneurogenesisbyinterleukin1signaling |