Peripapillary Microvascular Parameters in Unilateral Open-Angle Glaucoma Using the Optical Coherence Tomography-Angiography
Objective: This study compared the peripapillary retinal nerve fiber layer (pRNFL) microangiographic properties [vessel area density (VAD) and blood flux index (BFI)] of unilateral open-angle glaucomatous eyes to contralateral eyes-at-risk, and to eyes of healthy age- and sex-matched subjects. Me...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Philippine Academy of Ophthalmology
2022-12-01
|
| Series: | Philippine Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://paojournal.com/index.php/pjo/article/view/47 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850052125916135424 |
|---|---|
| author | Victor Ephraime V. Paulino, MD, DPBO John Mark S. de Leon, MD, DPBO |
| author_facet | Victor Ephraime V. Paulino, MD, DPBO John Mark S. de Leon, MD, DPBO |
| author_sort | Victor Ephraime V. Paulino, MD, DPBO |
| collection | DOAJ |
| description | Objective: This study compared the peripapillary retinal nerve fiber layer (pRNFL) microangiographic properties [vessel area density (VAD) and blood flux index (BFI)] of unilateral open-angle glaucomatous eyes to contralateral eyes-at-risk, and to eyes of healthy age- and sex-matched subjects.
Methods: This was a single-center, case-control study of Filipinos diagnosed with unilateral primary openangle glaucoma (POAG) or normal-tension glaucoma (NTG). Mean overall and quadrantal VAD and BFI of the three groups were measured with optical coherence tomography- angiography (OCT-A). Area under the receiver operating characteristic (AROC) was used to measure diagnostic ability.
Results: Twenty-two (22) glaucomatous subjects (15 POAG and 7 NTG eyes), 22 contralateral eyes-at-risk, and 22 normal eyes from age- and sex-matched control subjects completed the study. Eyes with glaucoma showed lower mean overall VAD (40%) and BFI (0.37) compared to eyes-at-risk (44.4% and 0.42, respectively; p <0.001) and control eyes (45.6% and 0.44, respectively; p <0.001). Mean VAD and BFI values of eyes-at-risk and control groups did not significantly differ from each other. Overall pRNFL thickness showed highest diagnostic accuracy for glaucoma (AROC = 0.97), followed by VAD (0.94), and BFI (0.88) (p=0.46).
Conclusion: VAD and BFI were significantly diminished in unilateral open-angle glaucoma, suggesting that the utility of OCT-A in the detection of glaucoma is comparable to pRNFL thickness. |
| format | Article |
| id | doaj-art-7eafc6ac9eec424b89c5f78f4522b06e |
| institution | DOAJ |
| issn | 0031-7659 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Philippine Academy of Ophthalmology |
| record_format | Article |
| series | Philippine Journal of Ophthalmology |
| spelling | doaj-art-7eafc6ac9eec424b89c5f78f4522b06e2025-08-20T02:52:56ZengPhilippine Academy of OphthalmologyPhilippine Journal of Ophthalmology0031-76592022-12-01472566347Peripapillary Microvascular Parameters in Unilateral Open-Angle Glaucoma Using the Optical Coherence Tomography-AngiographyVictor Ephraime V. Paulino, MD, DPBO0John Mark S. de Leon, MD, DPBO1Eye Institute, St. Luke’s Medical Center, Quezon City, Metro Manila, PhilippinesEye Institute, St. Luke’s Medical Center, Quezon City, Metro Manila, PhilippinesObjective: This study compared the peripapillary retinal nerve fiber layer (pRNFL) microangiographic properties [vessel area density (VAD) and blood flux index (BFI)] of unilateral open-angle glaucomatous eyes to contralateral eyes-at-risk, and to eyes of healthy age- and sex-matched subjects. Methods: This was a single-center, case-control study of Filipinos diagnosed with unilateral primary openangle glaucoma (POAG) or normal-tension glaucoma (NTG). Mean overall and quadrantal VAD and BFI of the three groups were measured with optical coherence tomography- angiography (OCT-A). Area under the receiver operating characteristic (AROC) was used to measure diagnostic ability. Results: Twenty-two (22) glaucomatous subjects (15 POAG and 7 NTG eyes), 22 contralateral eyes-at-risk, and 22 normal eyes from age- and sex-matched control subjects completed the study. Eyes with glaucoma showed lower mean overall VAD (40%) and BFI (0.37) compared to eyes-at-risk (44.4% and 0.42, respectively; p <0.001) and control eyes (45.6% and 0.44, respectively; p <0.001). Mean VAD and BFI values of eyes-at-risk and control groups did not significantly differ from each other. Overall pRNFL thickness showed highest diagnostic accuracy for glaucoma (AROC = 0.97), followed by VAD (0.94), and BFI (0.88) (p=0.46). Conclusion: VAD and BFI were significantly diminished in unilateral open-angle glaucoma, suggesting that the utility of OCT-A in the detection of glaucoma is comparable to pRNFL thickness.https://paojournal.com/index.php/pjo/article/view/47oct-angiographyperipapillary microcirculationblood flux indexvessel area densityunilateral glaucoma |
| spellingShingle | Victor Ephraime V. Paulino, MD, DPBO John Mark S. de Leon, MD, DPBO Peripapillary Microvascular Parameters in Unilateral Open-Angle Glaucoma Using the Optical Coherence Tomography-Angiography Philippine Journal of Ophthalmology oct-angiography peripapillary microcirculation blood flux index vessel area density unilateral glaucoma |
| title | Peripapillary Microvascular Parameters in Unilateral Open-Angle Glaucoma Using the Optical Coherence Tomography-Angiography |
| title_full | Peripapillary Microvascular Parameters in Unilateral Open-Angle Glaucoma Using the Optical Coherence Tomography-Angiography |
| title_fullStr | Peripapillary Microvascular Parameters in Unilateral Open-Angle Glaucoma Using the Optical Coherence Tomography-Angiography |
| title_full_unstemmed | Peripapillary Microvascular Parameters in Unilateral Open-Angle Glaucoma Using the Optical Coherence Tomography-Angiography |
| title_short | Peripapillary Microvascular Parameters in Unilateral Open-Angle Glaucoma Using the Optical Coherence Tomography-Angiography |
| title_sort | peripapillary microvascular parameters in unilateral open angle glaucoma using the optical coherence tomography angiography |
| topic | oct-angiography peripapillary microcirculation blood flux index vessel area density unilateral glaucoma |
| url | https://paojournal.com/index.php/pjo/article/view/47 |
| work_keys_str_mv | AT victorephraimevpaulinomddpbo peripapillarymicrovascularparametersinunilateralopenangleglaucomausingtheopticalcoherencetomographyangiography AT johnmarksdeleonmddpbo peripapillarymicrovascularparametersinunilateralopenangleglaucomausingtheopticalcoherencetomographyangiography |