Global research trends and focus on immunotherapy for endometrial cancer: a comprehensive bibliometric insight and visualization analysis (2012-2024)
BackgroundThis study conducted a novel systematic bibliometric and visualization analysis of global literature on immunotherapy for endometrial cancer (EC) to explore dynamic trends, research hotspots, and emerging topics, providing valuable references for future research.MethodsArticles and reviews...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571800/full |
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| author | Yachen Xu Yachen Xu Yachen Xu Yachen Xu Tao Wang Xiaojing Liang Xiaojing Liang Xiaojing Liang Xiaojing Liang Jie Yang Jie Yang Jie Yang Jie Yang Yuxiang Zhang Yuxiang Zhang Yuxiang Zhang Yuxiang Zhang Shan Bao Shan Bao Shan Bao Shan Bao |
| author_facet | Yachen Xu Yachen Xu Yachen Xu Yachen Xu Tao Wang Xiaojing Liang Xiaojing Liang Xiaojing Liang Xiaojing Liang Jie Yang Jie Yang Jie Yang Jie Yang Yuxiang Zhang Yuxiang Zhang Yuxiang Zhang Yuxiang Zhang Shan Bao Shan Bao Shan Bao Shan Bao |
| author_sort | Yachen Xu |
| collection | DOAJ |
| description | BackgroundThis study conducted a novel systematic bibliometric and visualization analysis of global literature on immunotherapy for endometrial cancer (EC) to explore dynamic trends, research hotspots, and emerging topics, providing valuable references for future research.MethodsArticles and reviews on EC immunotherapy published between 2012 and August 2024 were retrieved from the Web of Science Core Collection (WoSCC). Bibliometric tools, CiteSpace and VOSviewer, were used to analyze clustering patterns and research dynamics.ResultsA total of 861 articles were contributed by 5,331 authors from 1,392 institutions across 58 countries or regions, involving 1,823 keywords. China demonstrated outstanding performance in this field, contributing over 40% of the total publications and ranking first in publication volume. However, the total citation counts for publications from China lags that of the United States, highlighting the latter’s leading position and areas for further improvement in China’s research efforts. The University of Texas Medical Anderson Cancer Center and Nanjing Medical University were the two institutions with the highest number of publications. In terms of authorship, research teams led by Bosse, Tjalling, and Creutzberg, Carien L made significant contributions to advancing the field. Among individual publications, the work by Talhouk et al. achieved the highest average annual citation count of 70.88, demonstrating its profound impact. In terms of journals, Gynecologic Oncology emerged as a pivotal academic platform, publishing numerous articles and achieving the highest co-citation frequency. Additionally, Frontiers in Oncology, Frontiers in Immunology, and Frontiers in Genetics have become some of the most active and rapidly developing journals in recent years. Research hotspots are concentrated on themes such as the “Tumor Immune Microenvironment”, “Immune Checkpoint Inhibitors”, and “Targeted Therapy”. Recent trends and frontier research focus on the combined application of immune checkpoint inhibitors with other therapies, research on the application of nanotechnology in immunotherapy, and the integration of artificial intelligence to enhance precision medicine. Additionally, efforts are increasingly directed toward advancing various immunotherapy strategies from basic research to clinical applications.ConclusionsThis comprehensive analysis reveals rapid advancements and significant potential in EC immunotherapy. Strengthening international collaboration and addressing barriers in the translation of research to clinical practice will drive further progress in this promising field. |
| format | Article |
| id | doaj-art-7eae0f683a794d1b98df5cf58b92d6f7 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj-art-7eae0f683a794d1b98df5cf58b92d6f72025-08-20T02:08:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.15718001571800Global research trends and focus on immunotherapy for endometrial cancer: a comprehensive bibliometric insight and visualization analysis (2012-2024)Yachen Xu0Yachen Xu1Yachen Xu2Yachen Xu3Tao Wang4Xiaojing Liang5Xiaojing Liang6Xiaojing Liang7Xiaojing Liang8Jie Yang9Jie Yang10Jie Yang11Jie Yang12Yuxiang Zhang13Yuxiang Zhang14Yuxiang Zhang15Yuxiang Zhang16Shan Bao17Shan Bao18Shan Bao19Shan Bao20Department of Gynecology and Obstetrics, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, ChinaKey Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education, Haikou, ChinaHainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, ChinaMedical Laboratory Center, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, ChinaSchool of Public Health, Hainan Medical University, Haikou, ChinaDepartment of Gynecology and Obstetrics, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, ChinaKey Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education, Haikou, ChinaHainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, ChinaMedical Laboratory Center, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, ChinaDepartment of Gynecology and Obstetrics, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, ChinaKey Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education, Haikou, ChinaHainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, ChinaMedical Laboratory Center, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, ChinaDepartment of Gynecology and Obstetrics, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, ChinaKey Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education, Haikou, ChinaHainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, ChinaMedical Laboratory Center, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, ChinaDepartment of Gynecology and Obstetrics, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, ChinaKey Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education, Haikou, ChinaHainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, ChinaMedical Laboratory Center, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, ChinaBackgroundThis study conducted a novel systematic bibliometric and visualization analysis of global literature on immunotherapy for endometrial cancer (EC) to explore dynamic trends, research hotspots, and emerging topics, providing valuable references for future research.MethodsArticles and reviews on EC immunotherapy published between 2012 and August 2024 were retrieved from the Web of Science Core Collection (WoSCC). Bibliometric tools, CiteSpace and VOSviewer, were used to analyze clustering patterns and research dynamics.ResultsA total of 861 articles were contributed by 5,331 authors from 1,392 institutions across 58 countries or regions, involving 1,823 keywords. China demonstrated outstanding performance in this field, contributing over 40% of the total publications and ranking first in publication volume. However, the total citation counts for publications from China lags that of the United States, highlighting the latter’s leading position and areas for further improvement in China’s research efforts. The University of Texas Medical Anderson Cancer Center and Nanjing Medical University were the two institutions with the highest number of publications. In terms of authorship, research teams led by Bosse, Tjalling, and Creutzberg, Carien L made significant contributions to advancing the field. Among individual publications, the work by Talhouk et al. achieved the highest average annual citation count of 70.88, demonstrating its profound impact. In terms of journals, Gynecologic Oncology emerged as a pivotal academic platform, publishing numerous articles and achieving the highest co-citation frequency. Additionally, Frontiers in Oncology, Frontiers in Immunology, and Frontiers in Genetics have become some of the most active and rapidly developing journals in recent years. Research hotspots are concentrated on themes such as the “Tumor Immune Microenvironment”, “Immune Checkpoint Inhibitors”, and “Targeted Therapy”. Recent trends and frontier research focus on the combined application of immune checkpoint inhibitors with other therapies, research on the application of nanotechnology in immunotherapy, and the integration of artificial intelligence to enhance precision medicine. Additionally, efforts are increasingly directed toward advancing various immunotherapy strategies from basic research to clinical applications.ConclusionsThis comprehensive analysis reveals rapid advancements and significant potential in EC immunotherapy. Strengthening international collaboration and addressing barriers in the translation of research to clinical practice will drive further progress in this promising field.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571800/fullendometrial cancerimmunotherapybibliometric analysisresearch hotspotsemerging topics |
| spellingShingle | Yachen Xu Yachen Xu Yachen Xu Yachen Xu Tao Wang Xiaojing Liang Xiaojing Liang Xiaojing Liang Xiaojing Liang Jie Yang Jie Yang Jie Yang Jie Yang Yuxiang Zhang Yuxiang Zhang Yuxiang Zhang Yuxiang Zhang Shan Bao Shan Bao Shan Bao Shan Bao Global research trends and focus on immunotherapy for endometrial cancer: a comprehensive bibliometric insight and visualization analysis (2012-2024) Frontiers in Immunology endometrial cancer immunotherapy bibliometric analysis research hotspots emerging topics |
| title | Global research trends and focus on immunotherapy for endometrial cancer: a comprehensive bibliometric insight and visualization analysis (2012-2024) |
| title_full | Global research trends and focus on immunotherapy for endometrial cancer: a comprehensive bibliometric insight and visualization analysis (2012-2024) |
| title_fullStr | Global research trends and focus on immunotherapy for endometrial cancer: a comprehensive bibliometric insight and visualization analysis (2012-2024) |
| title_full_unstemmed | Global research trends and focus on immunotherapy for endometrial cancer: a comprehensive bibliometric insight and visualization analysis (2012-2024) |
| title_short | Global research trends and focus on immunotherapy for endometrial cancer: a comprehensive bibliometric insight and visualization analysis (2012-2024) |
| title_sort | global research trends and focus on immunotherapy for endometrial cancer a comprehensive bibliometric insight and visualization analysis 2012 2024 |
| topic | endometrial cancer immunotherapy bibliometric analysis research hotspots emerging topics |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571800/full |
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