Activation of store-operated calcium entry and mitochondrial respiration by enterovirus 71 is essential for efficient virus replication

Activation of store-operated calcium entry and mitochondrial respiration by enterovirus 71 is essential for efficient virus replication

ABSTRACT Enterovirus (EV) infections disrupt cellular calcium (Ca2+) homeostasis. The EV protein 2B is localized to the endoplasmic reticulum (ER) and causes depletion of ER Ca2+ stores. This depletion coincides with a substantial increase in cytosolic Ca2+ levels driven by extracellular Ca2+ influx...

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Bibliographic Details
Main Authors: Bang-Yan Hsu, Ya-Hui Tsai, Ta-Chou Weng, Szu-Hao Kung
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
enterovirus
calcium flux
SOCE
viral replication
electron transport chain
viral egress
Online Access:https://journals.asm.org/doi/10.1128/mbio.03717-24
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