The role of MYEOV gene: a review and future directions
The overexpressed gene MYEOV in multiple myeloma, as an oncogene, has been widely recognized for its high expression levels in various malignant tumors. MYEOV plays a significant role in multiple malignancies, particularly in diseases such as multiple myeloma, breast cancer, lung cancer, pancreatic...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1543590/full |
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| author | Yidan Xi Xuefei Liu Yanan Ge Mingzhe Jiang Dong Zhao Ershu Zhao Fei Cai Xinlong Wang Jiatong Li Tingting Li Zhendong Zheng |
| author_facet | Yidan Xi Xuefei Liu Yanan Ge Mingzhe Jiang Dong Zhao Ershu Zhao Fei Cai Xinlong Wang Jiatong Li Tingting Li Zhendong Zheng |
| author_sort | Yidan Xi |
| collection | DOAJ |
| description | The overexpressed gene MYEOV in multiple myeloma, as an oncogene, has been widely recognized for its high expression levels in various malignant tumors. MYEOV plays a significant role in multiple malignancies, particularly in diseases such as multiple myeloma, breast cancer, lung cancer, pancreatic cancer, and esophageal cancer. The presence of the open reading frame of MYEOV in humans and other primates suggests its potential protein-coding capacity, although direct evidence of functional MYEOV protein is currently lacking. The role of MYEOV in various tumors is not limited to its direct effects as an oncogene; it also includes its complex role in tumor cell signaling pathways and its ability to participate in miRNA regulatory networks as a competing endogenous RNA (ceRNA). Studies have shown that MYEOV may affect the expression of cancer-related genes through enhancer activity. This article aims to provide a comprehensive review of the role of MYEOV, its involvement in signaling pathways in tumor cells, and the latest advancements in MYEOV-targeted therapies. |
| format | Article |
| id | doaj-art-7ea8bf45d6d4447cac799d74d7d63a46 |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-7ea8bf45d6d4447cac799d74d7d63a462025-08-20T02:02:47ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-06-011510.3389/fonc.2025.15435901543590The role of MYEOV gene: a review and future directionsYidan Xi0Xuefei Liu1Yanan Ge2Mingzhe Jiang3Dong Zhao4Ershu Zhao5Fei Cai6Xinlong Wang7Jiatong Li8Tingting Li9Zhendong Zheng10Department of Oncology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Oncology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Oncology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Oncology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Oncology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Oncology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Oncology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Oncology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, ChinaDepartment of Oncology, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Oncology, General Hospital of Northern Theater Command, Shenyang, ChinaThe overexpressed gene MYEOV in multiple myeloma, as an oncogene, has been widely recognized for its high expression levels in various malignant tumors. MYEOV plays a significant role in multiple malignancies, particularly in diseases such as multiple myeloma, breast cancer, lung cancer, pancreatic cancer, and esophageal cancer. The presence of the open reading frame of MYEOV in humans and other primates suggests its potential protein-coding capacity, although direct evidence of functional MYEOV protein is currently lacking. The role of MYEOV in various tumors is not limited to its direct effects as an oncogene; it also includes its complex role in tumor cell signaling pathways and its ability to participate in miRNA regulatory networks as a competing endogenous RNA (ceRNA). Studies have shown that MYEOV may affect the expression of cancer-related genes through enhancer activity. This article aims to provide a comprehensive review of the role of MYEOV, its involvement in signaling pathways in tumor cells, and the latest advancements in MYEOV-targeted therapies.https://www.frontiersin.org/articles/10.3389/fonc.2025.1543590/fullMYEOVtargetbiomarker therapysignaling pathwaytumor |
| spellingShingle | Yidan Xi Xuefei Liu Yanan Ge Mingzhe Jiang Dong Zhao Ershu Zhao Fei Cai Xinlong Wang Jiatong Li Tingting Li Zhendong Zheng The role of MYEOV gene: a review and future directions Frontiers in Oncology MYEOV target biomarker therapy signaling pathway tumor |
| title | The role of MYEOV gene: a review and future directions |
| title_full | The role of MYEOV gene: a review and future directions |
| title_fullStr | The role of MYEOV gene: a review and future directions |
| title_full_unstemmed | The role of MYEOV gene: a review and future directions |
| title_short | The role of MYEOV gene: a review and future directions |
| title_sort | role of myeov gene a review and future directions |
| topic | MYEOV target biomarker therapy signaling pathway tumor |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1543590/full |
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