The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis
Low back pain (LBP) is seriously harmful to human health and produces heavy economic burden. And most scholars hold that intervertebral disc degeneration (IDD) is the primary cause of LBP. With the study of IDD, aberrant expression of gene has become an important pathogenic factor of IDD. Circular R...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2022/9550499 |
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| author | Hao Li Lijun Tian Jianhua Li Yongjin Li Lilong Du Zhenxin Huo Baoshan Xu |
| author_facet | Hao Li Lijun Tian Jianhua Li Yongjin Li Lilong Du Zhenxin Huo Baoshan Xu |
| author_sort | Hao Li |
| collection | DOAJ |
| description | Low back pain (LBP) is seriously harmful to human health and produces heavy economic burden. And most scholars hold that intervertebral disc degeneration (IDD) is the primary cause of LBP. With the study of IDD, aberrant expression of gene has become an important pathogenic factor of IDD. Circular RNAs (circRNAs), as a kind of noncoding RNA (ncRNA), participate in the regulation of genetic transcription and translation and further affect the expression of inflammatory cytokine, metabolism of extracellular matrix (ECM), the proliferation and apoptosis of cells, etc. Therefore, maybe it will become a new therapeutic target for IDD. At present, our understanding of the mechanism of circRNAs in IDD is limited. The purpose of this review is to summarize the mechanism and related signaling pathways of circRNAs in IDD reported in the past. Particularly, the roles of circRNAs in inflammation, ECM metabolism, and apoptosis are emphasized. |
| format | Article |
| id | doaj-art-7ea15694ffb245938e195f7ee907caf1 |
| institution | Kabale University |
| issn | 2210-7185 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-7ea15694ffb245938e195f7ee907caf12025-02-03T01:07:10ZengWileyAnalytical Cellular Pathology2210-71852022-01-01202210.1155/2022/9550499The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and ApoptosisHao Li0Lijun Tian1Jianhua Li2Yongjin Li3Lilong Du4Zhenxin Huo5Baoshan Xu6Department of Minimally Invasive Spine SurgeryGraduate SchoolDepartment of OrthopaedicsDepartment of Minimally Invasive Spine SurgeryDepartment of Minimally Invasive Spine SurgeryDepartment of Minimally Invasive Spine SurgeryDepartment of Minimally Invasive Spine SurgeryLow back pain (LBP) is seriously harmful to human health and produces heavy economic burden. And most scholars hold that intervertebral disc degeneration (IDD) is the primary cause of LBP. With the study of IDD, aberrant expression of gene has become an important pathogenic factor of IDD. Circular RNAs (circRNAs), as a kind of noncoding RNA (ncRNA), participate in the regulation of genetic transcription and translation and further affect the expression of inflammatory cytokine, metabolism of extracellular matrix (ECM), the proliferation and apoptosis of cells, etc. Therefore, maybe it will become a new therapeutic target for IDD. At present, our understanding of the mechanism of circRNAs in IDD is limited. The purpose of this review is to summarize the mechanism and related signaling pathways of circRNAs in IDD reported in the past. Particularly, the roles of circRNAs in inflammation, ECM metabolism, and apoptosis are emphasized.http://dx.doi.org/10.1155/2022/9550499 |
| spellingShingle | Hao Li Lijun Tian Jianhua Li Yongjin Li Lilong Du Zhenxin Huo Baoshan Xu The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis Analytical Cellular Pathology |
| title | The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis |
| title_full | The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis |
| title_fullStr | The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis |
| title_full_unstemmed | The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis |
| title_short | The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis |
| title_sort | roles of circrnas in intervertebral disc degeneration inflammation extracellular matrix metabolism and apoptosis |
| url | http://dx.doi.org/10.1155/2022/9550499 |
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