Recent advances in 3D-printing-based organ-on-a-chip
Organ-on-a-chip (OOC) facilitates precise manipulation of fluids in microfluidic chips and simulation of the physiological, chemical, and mechanical characteristics of tissues, thus providing a promising tool for in vitro drug screening and physiological modeling. In recent decades, this technology...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | EngMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950489924000034 |
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| author | Xinkun Wu Wenwan Shi Xiaojiang Liu Zhongze Gu |
| author_facet | Xinkun Wu Wenwan Shi Xiaojiang Liu Zhongze Gu |
| author_sort | Xinkun Wu |
| collection | DOAJ |
| description | Organ-on-a-chip (OOC) facilitates precise manipulation of fluids in microfluidic chips and simulation of the physiological, chemical, and mechanical characteristics of tissues, thus providing a promising tool for in vitro drug screening and physiological modeling. In recent decades, this technology has advanced rapidly because of the development of various three-dimensional (3D) printing techniques. 3D printing can not only fabricate microfluidic chips using materials such as resins and polydimethylsiloxane but also construct biomimetic tissues using bioinks such as cell-loaded hydrogels. In this review, recent advances in 3D-printing-based OOC are systematically summarized based on materials used for direct or indirect 3D printing of OOC, 3D printing techniques for the construction of OOC, and applications of 3D-printing-based OOC in models of the heart, blood vessels, intestines, liver, and kidney. Moreover, the paper outlines prospective vistas and hurdles within the field, intended to catalyze innovative use of 3D printing methodologies to propel OOC advancements. |
| format | Article |
| id | doaj-art-7e9ccde4fa7e498fa9b30cebb01ba4ee |
| institution | Kabale University |
| issn | 2950-4899 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EngMedicine |
| spelling | doaj-art-7e9ccde4fa7e498fa9b30cebb01ba4ee2025-01-11T06:42:26ZengElsevierEngMedicine2950-48992024-06-0111100003Recent advances in 3D-printing-based organ-on-a-chipXinkun Wu0Wenwan Shi1Xiaojiang Liu2Zhongze Gu3State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 211189, ChinaState Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 211189, ChinaState Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 211189, China; Corresponding author.State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 211189, China; Institute of Biomedical Devices (Suzhou), Southeast University, Suzhou 215163, Jiangsu, China; Corresponding author. State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 211189, China.Organ-on-a-chip (OOC) facilitates precise manipulation of fluids in microfluidic chips and simulation of the physiological, chemical, and mechanical characteristics of tissues, thus providing a promising tool for in vitro drug screening and physiological modeling. In recent decades, this technology has advanced rapidly because of the development of various three-dimensional (3D) printing techniques. 3D printing can not only fabricate microfluidic chips using materials such as resins and polydimethylsiloxane but also construct biomimetic tissues using bioinks such as cell-loaded hydrogels. In this review, recent advances in 3D-printing-based OOC are systematically summarized based on materials used for direct or indirect 3D printing of OOC, 3D printing techniques for the construction of OOC, and applications of 3D-printing-based OOC in models of the heart, blood vessels, intestines, liver, and kidney. Moreover, the paper outlines prospective vistas and hurdles within the field, intended to catalyze innovative use of 3D printing methodologies to propel OOC advancements.http://www.sciencedirect.com/science/article/pii/S29504899240000343D printingBioprintingOrgan-on-a-chipMicrofluidic chipsTissue engineering |
| spellingShingle | Xinkun Wu Wenwan Shi Xiaojiang Liu Zhongze Gu Recent advances in 3D-printing-based organ-on-a-chip EngMedicine 3D printing Bioprinting Organ-on-a-chip Microfluidic chips Tissue engineering |
| title | Recent advances in 3D-printing-based organ-on-a-chip |
| title_full | Recent advances in 3D-printing-based organ-on-a-chip |
| title_fullStr | Recent advances in 3D-printing-based organ-on-a-chip |
| title_full_unstemmed | Recent advances in 3D-printing-based organ-on-a-chip |
| title_short | Recent advances in 3D-printing-based organ-on-a-chip |
| title_sort | recent advances in 3d printing based organ on a chip |
| topic | 3D printing Bioprinting Organ-on-a-chip Microfluidic chips Tissue engineering |
| url | http://www.sciencedirect.com/science/article/pii/S2950489924000034 |
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