HLA-B∗57 and Gender Influence the Occurrence of Tuberculosis in HIV Infected People of South India
Background. Substantial evidence exists for HLA and other host genetic factors being determinants of susceptibility or resistance to infectious diseases. However, very little information is available on th...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/549023 |
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| author | Latha Jagannathan Mrinalini Chaturvedi Bhuthaiah Satish Kadappa Shivappa Satish Anita Desai D. K. Subbakrishna Parthasarathy Satishchandra Ramasamy Pitchappan Kamala Balakrishnan Paturu Kondaiah Vasanthapuram Ravi |
| author_facet | Latha Jagannathan Mrinalini Chaturvedi Bhuthaiah Satish Kadappa Shivappa Satish Anita Desai D. K. Subbakrishna Parthasarathy Satishchandra Ramasamy Pitchappan Kamala Balakrishnan Paturu Kondaiah Vasanthapuram Ravi |
| author_sort | Latha Jagannathan |
| collection | DOAJ |
| description | Background.
Substantial evidence exists for HLA and other
host genetic factors being determinants of
susceptibility or resistance to infectious
diseases. However, very little information is
available on the role of host genetic factors in
HIV-TB coinfection. Hence, a longitudinal
study was undertaken to investigate HLA
associations in a cohort of HIV seropositive
individuals with and without TB in Bangalore,
South India.
Methods. A cohort of 238 HIV seropositive
subjects were typed for HLA-A, B, and DR by PCR-SSP and followed up
for 5 years or till manifestation of Tuberculosis. HLA data
of 682 HIV Negative healthy renal donors was used as
control. Results. The ratio of males and females
in HIV cohort was comparable (50.4% and 49.6%). But the incidence
of TB was markedly lower in females (12.6%,) than males (25.6%).
Further, HLA-B*57 frequency in HIV cohort was
significantly higher among females without TB (21.6%, 19/88) than
males (1.7%, 1/59); P=0.0046; OR=38. CD4 counts also were higher among females in this cohort.
Conclusion. This study suggests that HIV positive women with HLA-B*57 have less occurrence of TB as compared to males. |
| format | Article |
| id | doaj-art-7e9c360b34b04d2bb3c3d48674486ee1 |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-7e9c360b34b04d2bb3c3d48674486ee12025-08-20T02:08:57ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/549023549023HLA-B∗57 and Gender Influence the Occurrence of Tuberculosis in HIV Infected People of South IndiaLatha Jagannathan0Mrinalini Chaturvedi1Bhuthaiah Satish2Kadappa Shivappa Satish3Anita Desai4D. K. Subbakrishna5Parthasarathy Satishchandra6Ramasamy Pitchappan7Kamala Balakrishnan8Paturu Kondaiah9Vasanthapuram Ravi10Rotary-TTK Blood Bank, Bangalore Medical Services Trust (BMST), Bangalore 560075, IndiaRotary-TTK Blood Bank, Bangalore Medical Services Trust (BMST), Bangalore 560075, IndiaHIV Services, Seva Free Clinic, Bangalore 560042, IndiaHIV Services, Seva Free Clinic, Bangalore 560042, IndiaDepartment of Neurovirology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore 560029, IndiaDepartment of Biostatistics, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore 560029, IndiaDepartment of Neurology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore 560029, IndiaDepartment of Immunology, School of Biological Sciences, Madurai Kamaraj University, Madurai 625021, IndiaHLA Laboratory, College of Medicine, University of Cincinnati, Ohio 45267-0550, USADepartment of Molecular Reproduction, Development and Genetics (MRDG), Indian Institute of Science (IISc), Bangalore 560012, IndiaDepartment of Neurovirology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore 560029, IndiaBackground. Substantial evidence exists for HLA and other host genetic factors being determinants of susceptibility or resistance to infectious diseases. However, very little information is available on the role of host genetic factors in HIV-TB coinfection. Hence, a longitudinal study was undertaken to investigate HLA associations in a cohort of HIV seropositive individuals with and without TB in Bangalore, South India. Methods. A cohort of 238 HIV seropositive subjects were typed for HLA-A, B, and DR by PCR-SSP and followed up for 5 years or till manifestation of Tuberculosis. HLA data of 682 HIV Negative healthy renal donors was used as control. Results. The ratio of males and females in HIV cohort was comparable (50.4% and 49.6%). But the incidence of TB was markedly lower in females (12.6%,) than males (25.6%). Further, HLA-B*57 frequency in HIV cohort was significantly higher among females without TB (21.6%, 19/88) than males (1.7%, 1/59); P=0.0046; OR=38. CD4 counts also were higher among females in this cohort. Conclusion. This study suggests that HIV positive women with HLA-B*57 have less occurrence of TB as compared to males.http://dx.doi.org/10.1155/2011/549023 |
| spellingShingle | Latha Jagannathan Mrinalini Chaturvedi Bhuthaiah Satish Kadappa Shivappa Satish Anita Desai D. K. Subbakrishna Parthasarathy Satishchandra Ramasamy Pitchappan Kamala Balakrishnan Paturu Kondaiah Vasanthapuram Ravi HLA-B∗57 and Gender Influence the Occurrence of Tuberculosis in HIV Infected People of South India Clinical and Developmental Immunology |
| title | HLA-B∗57 and Gender Influence the Occurrence of Tuberculosis in HIV Infected People of South India |
| title_full | HLA-B∗57 and Gender Influence the Occurrence of Tuberculosis in HIV Infected People of South India |
| title_fullStr | HLA-B∗57 and Gender Influence the Occurrence of Tuberculosis in HIV Infected People of South India |
| title_full_unstemmed | HLA-B∗57 and Gender Influence the Occurrence of Tuberculosis in HIV Infected People of South India |
| title_short | HLA-B∗57 and Gender Influence the Occurrence of Tuberculosis in HIV Infected People of South India |
| title_sort | hla b∗57 and gender influence the occurrence of tuberculosis in hiv infected people of south india |
| url | http://dx.doi.org/10.1155/2011/549023 |
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