Thalassemia
Defects in protein structure or synthesis of hemoglobin are called hemoglobinopathies. Thalassemia is the most common hemoglobinopathy, and it is estimated that 5% of the world population carries at least one variant allele of thalassemia. The thalassemias can be classified as alpha or beta thalass...
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Aydın Pediatric Society
2021-03-01
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| Series: | Trends in Pediatrics |
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| Online Access: | https://trendspediatrics.com/article/view/16 |
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| _version_ | 1849718324486733824 |
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| author | Tekin Aksu Sule Unal |
| author_facet | Tekin Aksu Sule Unal |
| author_sort | Tekin Aksu |
| collection | DOAJ |
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Defects in protein structure or synthesis of hemoglobin are called hemoglobinopathies. Thalassemia is the most common hemoglobinopathy, and it is estimated that 5% of the world population carries at least one variant allele of thalassemia. The thalassemias can be classified as alpha or beta thalassemias. Beta thalassemia may present as silent carriers with normal hematological parameters, while beta thalassemia carriers have hypochromic microcytic anemia, associated with a high HbA2. However, patients with beta thalassemia intermedia and beta thalassemia major need transfusion intermittently or regularly and they are called non-transfusion dependent thalassemias or transfusion-dependent thalassemias, respectively. This review focuses on pathophysiology, clinical, laboratory features of thalassemias along with their treatment and follow-up.
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| format | Article |
| id | doaj-art-7e9bc66216f7403c91afd618e80da9ef |
| institution | DOAJ |
| issn | 2792-0429 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Aydın Pediatric Society |
| record_format | Article |
| series | Trends in Pediatrics |
| spelling | doaj-art-7e9bc66216f7403c91afd618e80da9ef2025-08-20T03:12:24ZengAydın Pediatric SocietyTrends in Pediatrics2792-04292021-03-012110.5222/TP.2021.10820ThalassemiaTekin Aksu0https://orcid.org/0000-0003-4968-109XSule Unal1https://orcid.org/0000-0002-3842-8788Hacettepe University, Department of Pediatric Hematology, Ankara, TurkeyHacettepe University, Department of Pediatric Hematology, Ankara, Turkey Defects in protein structure or synthesis of hemoglobin are called hemoglobinopathies. Thalassemia is the most common hemoglobinopathy, and it is estimated that 5% of the world population carries at least one variant allele of thalassemia. The thalassemias can be classified as alpha or beta thalassemias. Beta thalassemia may present as silent carriers with normal hematological parameters, while beta thalassemia carriers have hypochromic microcytic anemia, associated with a high HbA2. However, patients with beta thalassemia intermedia and beta thalassemia major need transfusion intermittently or regularly and they are called non-transfusion dependent thalassemias or transfusion-dependent thalassemias, respectively. This review focuses on pathophysiology, clinical, laboratory features of thalassemias along with their treatment and follow-up. https://trendspediatrics.com/article/view/16Beta thalassemiaAlpha thalassemiaPathophysiologyTreatment |
| spellingShingle | Tekin Aksu Sule Unal Thalassemia Trends in Pediatrics Beta thalassemia Alpha thalassemia Pathophysiology Treatment |
| title | Thalassemia |
| title_full | Thalassemia |
| title_fullStr | Thalassemia |
| title_full_unstemmed | Thalassemia |
| title_short | Thalassemia |
| title_sort | thalassemia |
| topic | Beta thalassemia Alpha thalassemia Pathophysiology Treatment |
| url | https://trendspediatrics.com/article/view/16 |
| work_keys_str_mv | AT tekinaksu thalassemia AT suleunal thalassemia |